Category: Clia Kits

KarinaDecember 22, 2020

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

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Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. SEPIN-1…

KarinaDecember 22, 2020

Identification of Bioactive Small Molecule Inhibitors of Separase.

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Identification of Bioactive Small Molecule Inhibitors of Separase.

Sepased, a cysteine protease of the CD clan, triggers the segregation of chromosome during mitosis by cleaving the cohesine ring…

KarinaDecember 22, 2020

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

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[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

GOAL To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and…

KarinaDecember 22, 2020

Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

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Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

Prostate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used…

KarinaAugust 8, 2020

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

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Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

ESPL1 / separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. aberrant expression…

KarinaAugust 8, 2020

Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

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Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of…

KarinaAugust 8, 2020

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

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Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

Separase, a cysteine endopeptidase, are key players in the mitotic sister chromatid separation, the dynamics of the replication fork, and…

KarinaAugust 8, 2020

Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

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Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

Separation of sister chromatids during the eukaryotic cell cycle time with the spindle assembly checkpoint (SAC) and finally triggered when…

KarinaAugust 8, 2020

Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion

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Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion

Tetraploidy, a common feature on cancer, results in the presence of extra centrosomes, which have been associated with chromosomal instability…