Category: Medium & Serums

KarinaDecember 22, 2020

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

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The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

During mitotic prohase, cohesins are removed from the chromosome arms by WAPP to ensure a faithful separation of the Chromatide…

KarinaAugust 8, 2020

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

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Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

ESPL1 / separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. aberrant expression…

KarinaAugust 8, 2020

Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

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Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of…

KarinaAugust 8, 2020

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

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Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

Separase, a cysteine endopeptidase, are key players in the mitotic sister chromatid separation, the dynamics of the replication fork, and…

KarinaAugust 8, 2020

Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

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Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

Separation of sister chromatids during the eukaryotic cell cycle time with the spindle assembly checkpoint (SAC) and finally triggered when…

KarinaAugust 8, 2020

Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion

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Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion

Tetraploidy, a common feature on cancer, results in the presence of extra centrosomes, which have been associated with chromosomal instability…