Sepased, a cysteine ​​protease of the CD clan, triggers the segregation of chromosome during mitosis by cleaving the cohesine ring entering the two sister chromatids. The separate sepaase activity is associated with aneuploidy, a characteristic of most human cancer. In fact, separated is very overexpressed in many solid cancers, making it an attractive chemotherapeutic target. To identify small molecules capable of inhibiting separated in its complex cellular environment, we have established an extremely sensitive dosage to quantify the sepaase activity in the cells and screened a library of 51 009-members for separation inhibitors. The in vitro tests confirmed that the identified compounds inhibited effectively separated, while making any impact on CASPASE-1, another structurally related CD-clan protease related to Separase.

It is important to note that the HELA cells with a compromised sepaase activity displayed severe chromosome segregation defects during compound treatment, confirming that identified inhibitors are bioactive in tumor tissue culture cells. Structure-activity relationship studies have succeeded the most promising inhibitor optimization. Overall, this study demonstrates the feasibility of identifying separation-specific inhibitors, which serve promising lead compounds for the development of clinically relevant separation inhibitor drugs. To complement mitosis, Saccharomyces cerevisiae must activate mitotic CDC14 phosphatase. Two ways contribute to the regulations of the CDC14: fear (CDC14 anapthase released) and men (mitotic output network). The CDC5 polo-type kinase has proven to be an important mitotic output component.

However, its specific role in the regulation of the mitotic exit and its participation in the release of the CDC14 remain uncertain. Here we provide an overview of the mechanism by which CDC5 contributes to the rapid release of CDC14. Our genetic and biochemical data indicate that CDC5 acts in parallel with men during anaphase. This independent CDC5 function of men requires an active separation and activation by the dependent phosphorylation of the CDK1. CDK1 first phosphorylates CDC5 to activate it in an early anaphase, then, at the end of anaphase, another phosphorylation of CDC5 by CDK1 is necessary to promote its functions related to men.

 

Patronus is the unisisable securin plant, thus preventing the separation of chromosome by sepaase antagonization.

The distribution of chromosomes in mitose and meiosis anaphase is triggered by Separase, a protease preserved evolutionally. Sepases must be tightly set to prevent premature release of chromatide cohesion and disastrous chromosom distribution defects. Securin is the sepaase key inhibitor in animals and fungi, but has not been identified in other eukaryotic lines.

Here we have identified Patronus1 and Patronus2 (Pans1 and Pans2) as Securin Arabidopsis counterparts. The disturbance of Pans1 is known to cause premature separation of chromosomes to meiosis and simultaneous disturbance of Pans1 and Pans2 is deadly. We show here that Pans1 targeting the complex favoring anaphase is necessary to trigger the separation of the chromosome, reflecting the regulation of securin. We showed that Pans1 acts independently of Shugosins. In a genetic screen for PANS1 suppressors, we have identified separate mutants, showing that Pans1 and Separase have in vivo antagonistic functions.

Finally, we have shown that Pans1 and Pans2 proteins interact directly with sepaase. In total, our results show that Pans1 and Pans2 act as a securin plant. Remote sequence similarity has been identified between the patronus family of the plant and the securins of animals, suggesting that they derive indeed a common ancestor.

IDENTIFICATION OF PATRONUS Like the unisisable securin plant illustrates the divergence extreme sequence of this central mitosis and meiosis regulator.

Sepease is a marker for prognosis and mitotic activity in breast cancer.

 

BACKGROUND
Cancer cell proliferation is an important feature in classifying and predicting the results of breast carcinoma. Sepease has a central role in the development of the cell cycle in releasing brothers and brothers on an onset anafase. Sepeangases that function abnormally are known to cause chromosome instability.

Method.
The study consisted of 349 breast carcinoma patients treated at Central Finnish Central Hospital. Prognostic value, the role of a signage marker and separate regulatory interaction is evaluated by detection of immunohistochemicals and double-and triple-immunofluorescence (IF) based on complete clinical data and >> 22 years of follow-up from patient materials.

Results
In our material, abnormal separation expression estimates the risk of breast cancer death (P <0.001). The difference in survival of up to 11.3 years was observed when comparing patients with and without separatists expressing mitotic cancer cells. In particular, the expression of abnormal dividing expects survival disorders to luminal breast carcinoma (P <0.001, respectively). In multivariate analysis, abnormal expression of separation shows independent prognostic value. Complex inhibitory interactions involving Securin and Cyclin B1 are investigated in double and triple and reveals subgroups of patients with rules that deviate and separate expression patterns.

Separase (pS801) Antibody
20-abx134111	Abbexa	EUR 376.80 EUR 560.40 EUR 243.60	100 ul 200 ul 30 ul

SEPARASE antibody (Ser801)
70R-31053	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

Separase Conjugated Antibody
C44415	SAB	100ul	EUR 476.4

Separase Polyclonal Antibody
ABP52424-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody
ABP52424-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody
ABP52424-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody
ES3423-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Polyclonal Antibody
ES3423-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Blocking Peptide
AF9195-BP	Affbiotech	1mg	EUR 234

Separase Blocking Peptide
20-abx161616	Abbexa	EUR 326.40 EUR 493.20	1 mg 5 mg

SEPARASE Cell ELISA Kit
abx595539-96tests	Abbexa	96 tests	EUR 764.4

Separase (pS801) Blocking Peptide
20-abx162232	Abbexa	EUR 376.80 EUR 610.80	1 mg 5 mg

Separase (phospho Ser801) Polyclonal Antibody
ABP50519-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody
ABP50519-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody
ABP50519-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody
ES1518-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Polyclonal Antibody
ES1518-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (Phospho-Ser801) Polyclonal Antibody
12353-100ul	SAB	100ul	EUR 302.4

Separase (Phospho-Ser801) Polyclonal Antibody
12353-50ul	SAB	50ul	EUR 224.4

Polyclonal ESPL1 / Separase Antibody (aa767-816)
APR02989G	Leading Biology	0.05ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

SEPARASE Colorimetric Cell-Based ELISA Kit
EKC1516	BosterBio	100ul	EUR 686.4

SEPARASE Colorimetric Cell-Based ELISA Kit (OKAG01028)
OKAG01028	Aviva Systems Biology	96 Wells	EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse;Application: ELISA;Assay info: Assay Type: Cell-Based Subtype: None Detection Method: Colorimetric 450 nm;Sensitivity:

SEPARASE (Phospho-Ser801) Colorimetric Cell-Based ELISA Kit
EKC2000	BosterBio	100ul	EUR 686.4

Addi platform separators (4 ea) Add 1.25 to platform separation
MIX7118	Scientific Laboratory Supplies	EACH	EUR 74.4

Separator
INS6224	Scientific Laboratory Supplies	EACH	EUR 20.4

Additional platform separators (4 ea.). Adds 1.25" to platform separation
BR2000-SP	Benchmark Scientific	1 PC	EUR 52.8

Puck Separator
M-CBP-PST1	MiTeGen	1 UNIT	EUR 340
Description: Puck Separator

Separator UB 200mm
SIE1104	Scientific Laboratory Supplies	EACH	EUR 126.64

anti-Separase
YF-PA25396	Abfrontier	50 ul	EUR 400.8
Description: Mouse polyclonal to Separase

Phase Separator 15ml
CHR5382	Scientific Laboratory Supplies	PK100	EUR 139.2

Phase Separator 25ml
CHR5384	Scientific Laboratory Supplies	PK100	EUR 152.76

Phase Separator 70ml
CHR5386	Scientific Laboratory Supplies	PK50	EUR 116.4

Phase Separator 150ml
CHR5388	Scientific Laboratory Supplies	PK25	EUR 145.2

Puck Separator Tools
M-CP-111-028	MiTeGen	1 UNIT	EUR 305
Description: Puck Separator Tools

Magnetic Separator
B23803	Bimake	2 mL/200 uL/15 mL	EUR 291.6
Description: This Magnetic Separator is a proprietary machine, supportinga the magnetic beads series of products. A core tenent is the use of a superior magnetic, to ensure that magnetic separation step can be completed in a short time.

Magnetic Separator
MagSep1-1	ABTBeads	1/pk	EUR 132

McDonald Separator
INS6226	Scientific Laboratory Supplies	EACH	EUR 16.8

MiniTube Mag Separator
MTMS-16	Spherotech	mL	EUR 432
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Jenway Water Separator
FLA1034	Scientific Laboratory Supplies	EACH	EUR 184.8

Separating Funnel PP 500ml
FUN21060	Scientific Laboratory Supplies	PK2	EUR 93.6

50ml Separating Funnel
FUN4123	Scientific Laboratory Supplies	EACH	EUR 104.4

Pyrex 1L Separating Funnel
FUN4126	Scientific Laboratory Supplies	EACH	EUR 139.2

Pyrex 2L Separating Funnel
FUN4128	Scientific Laboratory Supplies	EACH	EUR 187.2

Separatory Funnel Pear 500ml
2394T/500	Scientific Laboratory Supplies	PK2	EUR 244.8

Magnetic Separation Rack
M1501-1	Biovision	1 Rack	EUR 454.8

Separating Funnel Pear 1000ml
FUN20650	Scientific Laboratory Supplies	PK2	EUR 205.2

Separating Funnel Pear 50ml
FUN2081	Scientific Laboratory Supplies	EACH	EUR 74.4

Separating Funnel Pear 100ml
FUN2083	Scientific Laboratory Supplies	EACH	EUR 85.2

Separating Funnel Pear 250ml
FUN2085	Scientific Laboratory Supplies	EACH	EUR 90

2L P/Shaped Separating Funnel
FUN4310	Scientific Laboratory Supplies	EACH	EUR 207.6

Separating Funnel Holder
STA1094	Scientific Laboratory Supplies	EACH	EUR 39.24

Magnetic Separation Rack
CM101	Vazyme	32 well (200 μl/well)	EUR 112

Magnetic Separation Rack
CM103	Vazyme	24 well (1.5 ml/well)	EUR 112

Separating funnel 100ML PTFE Key
8S149/100	Scientific Laboratory Supplies	EACH	EUR 45.6

Separating Funnel 500ml PTFE Key
8S149500	Scientific Laboratory Supplies	EACH	EUR 56.4

Jenway Water Separator Large
FLA1036	Scientific Laboratory Supplies	EACH	EUR 224.4

Pyrex 100ml Separating Funnel
FUN4120	Scientific Laboratory Supplies	EACH	EUR 104.4

Pyrex 250ml Separating Funnel
FUN4122	Scientific Laboratory Supplies	EACH	EUR 114

Pyrex 500ml Separating Funnel
FUN4124	Scientific Laboratory Supplies	EACH	EUR 120

Funnel Pyrex Separating Pear 5L
FUN4312	Scientific Laboratory Supplies	EACH	EUR 309.6

Cardboard Separator kit for xxxx
CRY2076	Scientific Laboratory Supplies	PK6	EUR 26.4

Long Form Separating Funnel 50ml
8S14950	Scientific Laboratory Supplies	EACH	EUR 44.4

50ml P/Shaped Separating Funnel
FUN4300	Scientific Laboratory Supplies	EACH	EUR 110.4

Magnetic Separator (Re-usable)
1999-1	Biovision	each	EUR 319.2

MicroMag Magnetic Separator
MMS-2100	Spherotech	mL	EUR 498
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

FlexiMag Magnetic Separator
FMS-1000	Spherotech	mL	EUR 583.2
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

FlexiMag Magnetic Separator
FMJ-1000	Spherotech	mL	EUR 432
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Nalgene 125ml Separating Funnel PP
FUN4180	Scientific Laboratory Supplies	EACH	EUR 97.2

HandiMag Magnetic Separator
HMS-1000	Spherotech	mL	EUR 218.4
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

UltraMag DW Magnetic Separator
UMDS-1000	Spherotech	mL	EUR 741.6
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

UltraMag Magnetic Separator
UMS-3000	Spherotech	mL	EUR 736.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Statebourne 1 2 BSP Phase Separator
CRY2104	Scientific Laboratory Supplies	EACH	EUR 147.53

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200070	Scientific Laboratory Supplies	EACH	EUR 45.6

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200110	Scientific Laboratory Supplies	PK100	EUR 60

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200125	Scientific Laboratory Supplies	PK100	EUR 68.4

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200150	Scientific Laboratory Supplies	PK100	EUR 96

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200185	Scientific Laboratory Supplies	EACH	EUR 110.4

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200240	Scientific Laboratory Supplies	EACH	EUR 154.8

WHATMAN(R) 1PS PHASE SEPARATOR FILTER PA
WHA2200270	Scientific Laboratory Supplies	EACH	EUR 238.8

T-Pro Separating or Resolving Buffer
JB03-C001	T-Pro Biotechnology	500ml/BT	EUR 182.4

EpiMag HT (96-Well) Magnetic Separator
Q10002	EpiGentek	EUR 416.70 EUR 258.50	1/Pack 1/Pack

WHATMAN(R) TG100 SEPARATION GAUZE DIAM
WHA10423029	Scientific Laboratory Supplies	EACH	EUR 174

100 ML LSM (LYMPHOCYTE SEPARATION MEDIUM)
25-072-CI	CORNING	100 mL/pk	EUR 63.6
Description: Media Catalog; Cell Culture Reagents

Separator type 10001 for drawers capacity 10000 cm3
DD039473	Scientific Laboratory Supplies	EACH	EUR 7.2

PCR 8-Strips, 0.2ml with Separate Flat Cap Strips, 120/pk
P3010-S	MTC Bio	120/pack	EUR 116.7
Description: PCR 8-Strips 0.2ml with Separate Flat Cap Strips

Anti-Separase Antibody
A04364	BosterBio	100ul	EUR 476.4
Description: Rabbit Polyclonal Antibody for Separase Antibody (ESPL1) detection. Tested with WB, IHC, IF in Human, Mouse.

Anti-Separase antibody
STJ95608	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Separase.

Culture Tube, 5mL, 12 x 75mm, PP, w/ separate 2-position screw-cap, non-sterile, non-graduated, 1000 tubes and capped bulk packed separately
T8750	MTC Bio	1000/pack	EUR 147.48
Description: Culture Tube 5mL

Culture Tube, 14mL, 17 x 100mm, PP, w/ separate 2-position screw-cap, non-sterile, non-graduated, 1000 tubes and capped bulk packed separately
T8850	MTC Bio	1000/pack	EUR 228.48
Description: Culture Tube 14mL

Lymphocyte separation medium (human)
abx082102-200ml	Abbexa	200 ml	EUR 243.6

Cytosol/Particulate Separation Kit
55R-1356	Fitzgerald	50 assays	EUR 661.2
Description: Cytosol/Particulate Separation Kit for use in the research laboratory

Cytosol/Particulate Separation Kit
K267-50	Biovision	each	EUR 483.6

Cytosol/Particulate Separation Kit
K2112-50	ApexBio	50 assays	EUR 501.6

WHATMAN 1PS PHASE SEPARATOR FILTER PAPER
WHA2200090	Scientific Laboratory Supplies	EACH	EUR 49.2

Anti-Separase (6H6)
YF-MA11199	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to Separase

1-Step Polymorphs, Human Cell Separation
71-AN221725	Gentaur Genprice	1	EUR 238.8

Taq DNA Polymerase - 5,000 units with separate dNTP Mix
3245d	Intact Genomics	1/EA	EUR 802.8

Techne Separation Membranes 200x200mm
OVE3038	Scientific Laboratory Supplies	PK5	EUR 181.2

Custom drilling for BSW01 (sold separately) up to 36 holes
BLO1274	Scientific Laboratory Supplies	EACH	EUR 260.4

Custom drilling for BSW01 (sold separately), up to 36 holes
BSW01-DR	Benchmark Scientific	1 PC	EUR 195.3

Funnel Separating Conical Ptfe Stopcock 100ml
E4606	Scientific Laboratory Supplies	EACH	EUR 33.6

Funnel Separating Conical Ptfe Stopcock 250ml
E4607	Scientific Laboratory Supplies	EACH	EUR 43.2

Orion Star A211 pH Benchtop Meter Separate Sensor Kit
STARA2118	Scientific Laboratory Supplies	EACH	EUR 1358.4

Mercury is supplied as a separate solution (PLHG-1Y).
TCLP-100	Scientific Laboratory Supplies	125ML	EUR 253.2

Mercury is supplied as a separate solution (PLHG-1X).
TCLP-500	Scientific Laboratory Supplies	500ML	EUR 429.6

Stacking platform, small 10.5"x7.5" with flat mat (3.0"separation)
B3D-STACK	Benchmark Scientific	1 PC	EUR 135.8

Corning 500mL LSM (Lymphocyte Separation Medium)
25-072-CV	Scientific Laboratory Supplies	EACH	EUR 156

Clear Glass Powder Bottle with Separate Black Cap - 15mL
BOT1200	Scientific Laboratory Supplies	PK140	EUR 87.6

Clear Glass Powder Bottle with Separate Black Cap - 30mL
BOT1201	Scientific Laboratory Supplies	PK80	EUR 49.2

Clear Glass Powder Bottle with Separate Black Cap - 60mL
BOT1204	Scientific Laboratory Supplies	PK72	EUR 50.4

Clear Glass Powder Bottle with Separate Black Cap - 125mL
BOT1206	Scientific Laboratory Supplies	PK80	EUR 60

Clear Glass Powder Bottle with Separate Black Cap - 250mL
BOT1211	Scientific Laboratory Supplies	PK42	EUR 37.2

Clear Glass Powder Bottle with Separate Black Cap - 500mL
BOT1212	Scientific Laboratory Supplies	PK33	EUR 50.4

Amber Glass Powder Bottle with Separate Black Cap - 30mL
BOT1220	Scientific Laboratory Supplies	PK127	EUR 81.6

Amber Glass Powder Bottle with Separate Black Cap - 60mL
BOT1222	Scientific Laboratory Supplies	PK72	EUR 40.8

Amber Glass Powder Bottle with Separate Black Cap - 250mL
BOT1226	Scientific Laboratory Supplies	PK42	EUR 74.4

Amber Glass Powder Bottle with Separate Black Cap - 500mL
BOT1228	Scientific Laboratory Supplies	PK28	EUR 39.6

Mercury is supplied as a separate solution (PLHG-1AX).
EP-8-500	Scientific Laboratory Supplies	500ML	EUR 366

Mercury is supplied as a separate solution (PLHG2-1Y).
LPC-1-100	Scientific Laboratory Supplies	125ML	EUR 528

Mercury is supplied as a separate solution (PLHG2-1X).
LPC-1-500	Scientific Laboratory Supplies	500ML	EUR 912

0.1ml qPCR 8-Strip (With SEPARATE Optical Strip Caps), WHITE 120/pk
P3801-QW	MTC Bio	120/pack	EUR 162.06
Description: 0.1ml qPCR 8-Strip ,white 120

0.2ml qPCR 8-Strip (With SEPARATE Optical Strip Caps), WHITE, 120/pk
P3802-QW	MTC Bio	120/pack	EUR 162.06
Description: 0.2ml qPCR 8-Strip , white

Stacking platform small 10.5x7.5 w flat mat (3.0separation)
MIX7112	Scientific Laboratory Supplies	EACH	EUR 182.4

Simax Separating Funnel Cylindrical Open 50ml
FUN2060	Scientific Laboratory Supplies	EACH	EUR 46.8

Simax Separating Funnel Cylindrical Open 100ml
FUN20660	Scientific Laboratory Supplies	PK4	EUR 180

Pyrex Separating Funnel 100ml Glass Stopcock Pear
FUN4322	Scientific Laboratory Supplies	EACH	EUR 117.6

Mercury is supplied as a separate solution (PLHG2-1Y).
INTER18-100	Scientific Laboratory Supplies	125ML	EUR 501.6

Mercury is supplied as a separate solution (PLHG2-1X).
INTER18-500	Scientific Laboratory Supplies	500ML	EUR 874.8

Mercury is supplied as a separate solution (PLHG2-AY).
WP-15	Scientific Laboratory Supplies	125ML	EUR 328.8

Stacking platform, large 12"x12" with flat mat (3.0" separation)
BR1000-STACK	Benchmark Scientific	1 PC	EUR 135.8

Mercury is supplied as a separate solution (PLHG2-1AY).
EP-8	Scientific Laboratory Supplies	125ML	EUR 220.8

PCR Tubes Strips of 8 tubes w/ dome caps packaged separately, 120/pk
P3020	MTC Bio	120/pack	EUR 118.32
Description: PCR Tubes Strips of 8 tubes w/ dome caps packaged separately120

Stacking platform large 12x12 w flat mat (3.0 separation)
MIX7114	Scientific Laboratory Supplies	EACH	EUR 182.4

Conclusion.
In our experience, Sepease is a promising proliferation marker and applied clinically. Sepeanase expressions show strong and independent prognostic values ​​and can be developed into biomarkers for treatment decisions in breast carcinoma, mainly defining the prognostic subgroup among luminal carcinoma.