Structure and Function of the Separase-Securin Complex
Sepaase is a large protease of cysteine in eukaryotes and presents crucial roles in many cell processes, in particular chromosomal…
Read MoreDuring mitotic prohase, cohesins are removed from the chromosome arms by WAPP to ensure a faithful separation of the Chromatide…
Read MoreProstate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used…
Read MoreESPL1 / separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. aberrant expression…
Read MoreSepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of…
Read MoreSeparase, a cysteine endopeptidase, are key players in the mitotic sister chromatid separation, the dynamics of the replication fork, and…
Read MoreSeparation of sister chromatids during the eukaryotic cell cycle time with the spindle assembly checkpoint (SAC) and finally triggered when…
Read MoreTetraploidy, a common feature on cancer, results in the presence of extra centrosomes, which have been associated with chromosomal instability…
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