Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

Prostate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used treatment for men with prostate cancer, harmful effects can affect patient health and quality of life. Therefore, identifying new target genes for tumor growth will develop new therapeutic intervention. TPX2 plays a vital role in chromosomal segregation machines during mitosis. The low rate of bad chromosomal inserted can promote the development of the tumor, while higher levels could promote cell death and remove tumorigenesis. Therefore, the strategy for promoting cell death by inducing poor massive chromosome unspede has been a selectively eliminating therapeutic application of extremely proliferative tumor cells.

RNAI has been used for the reversal of the expression of TPX2 proteins and a clonogenic dosage, an immunostable block, a double thymidine, an image cytometry analysis and a tumor spheroid test have been used to analyze the role of TPX2 in the Growth of tumor cells, the progression of the cell cycle, the multinaresis, the ploidy, and tumorenicity, respectively; Finally, Western blotting has been used to analyze the anticancer mechanisms in TPX2 targeting. We have demonstrated that targeting reduced cell cycle regulations of TPX2 and chromosomal segregation genes, resulting in increased cell micronuclearization.

In addition, TPX2 exhaustion resulted in an inhibition of the growth of the prostate cancer cell, an increase in apoptosis and reduced tumorigenesis. These results confirmed the therapeutic potential to target TPX2 in the treatment of prostate cancer. In addition, we found that the TPX2 silencer led to the deregulation of CDK1, cyclin B, Securin, separated and arouped a protein; On the other hand, the P21 mRNA has been regulated. We also determined the Molecular TPX2 targeting mechanisms in prostate cancer cells. In conclusion, our study illustrates the power of TPX2 as a new target gene for the treatment of prostate cancer.

 

Synthesis and activity of benzimidazole-1,3-sepaase dioxide inhibitors.

Due to the oncogenic activity of the cohesic protease, separated in human cancer cells, the modulation of an enzymatic separation activity could constitute a new therapeutic strategy to target aneuploid tumors resistant to the overloid. In this, we signal the synthesis, the structural information and the structure-activity structure (SAR) of separate inhibitors based on the modification of the lead molecule 2,2-dimethyl-5-nitro-2h-benzimidazole-1 , 3-dioxide, named sepin -1, (1) identified from a broadband screen.

The replacement of -NO2 to C5 with other functional groups reduced the inhibitory activity in the enzymatic dosage separated. The substitution of the two methyl groups with other C2 alkyl chains moderately improves the effects on the inhibitory activity of these compounds. The modifications of 2h-benzimidazole-1,3-dioxide or skeleton have a variable effect on the inhibition of the enzymatic sepaase activity. The functional theoretical calculations of density (DFT) suggest that there may be a correlation between the loads of the oxide fragments on these compounds and their activity in the inhibition of the sepaase enzyme. The morphogenesis of the plants depends on the synchronized anisotropic expansion of individual cells in response to development and environmental signals.

The magnitude of cell dilation depends on the biomechanical properties of the cell wall, which depends both on its biosynthesis and its extensibility. Although the control of cell expansion by phytohormone Auxin has established, its regulation of the composition of the cell wall, the traffic of the cuases H +, and K + influx which leads to growth is always elucidated. In addition, the maintenance of auxin flows via the interaction between the cytoskeleton and the recycling of the spindle proteins on the plasma membrane remains under study.

 Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.
Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

The release of centrosio and centrosome fragmentation caused by mitotic delays.

The Spindle Assembly (SAC) inspection post postponed mitosis until all female chromatid pairs reached two orientations, and while bags could maintain mitotic capture for an extended period, moderate delay in mitotic development has a significant effect on the cells of the child produced. Here we show that when epithelial cells (RPE1) pigmented retina experiences mitotic delays, there is an increase that depends on the time in centrosome fragmentation and the release of centrole. While most cells with centrioles that are released maintaining spindle bipolarity, the grouping of centriolyes that are released requires Kinesin-14, hset.

The centrosome fragmentation and mature centriol relevance relies on complex / cyclosomom / cyclosomom (APC / c) which triggered, which also triggered the acquisition of distal complementary markers on the child’s centrioly and the loss of procentive markers. Together, these results indicate that moderate delays in mitotic development triggered the initiation of centriol licenses through the release of centriol, at that time the ability to maintain spindle bipolarity into a functions of grouping spindle poles mediated by hset. The cells undergo meiosis produce haploid gamets through one round of DNA replication followed by 2 rounds of chromosome separation.

It requires a cohesin complex, which forms brother chromatid cohesion during phase S, is removed gradually. In Meiosis I, separate proteases triggered a segregation of homologous chromosomes by dividing the rec8 cohesin subunit on the chromosome arm. Cohesin survived at the Centromeres because PP2A Phosphatase, was recruited by Shugoshin’s protein, eliminating Rechosterlate Rec8 and thus protecting it from the cleavage. While chromatid was disinitized in the cleavage of the rec8 centromer in meiosis II, it was not clear how and when the Centromercon Rec8 was released from the PP2A protector. One proposal is that the power of the bipolar spindle separates PP2A from REC8 as a cell in Metaphase II.

 

Separase (phospho Ser801) Polyclonal Antibody

E44H00548 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase (Phospho-Ser801) Polyclonal Antibody

12353 100ul
EUR 319

Separase (Phospho-Ser801) Polyclonal Antibody

12353-100ul 100ul
EUR 302.4

Separase (Phospho-Ser801) Polyclonal Antibody

12353-50ul 50ul
EUR 224.4

Separase (Phospho-Ser801) Polyclonal Antibody

E012353 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Rabbit pAb

E2252078 100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

20-abx121903
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  • 100 ul
  • 200 ul
  • 30 ul

Separase Antibody

44415-100ul 100ul
EUR 302.4

Separase Antibody

44415-50ul 50ul
EUR 224.4

Separase Antibody

20-abx215242
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  • 100 ug
  • 50 ug

Separase Antibody

E18-9195-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Separase Antibody

E18-9195-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

E38PA4405 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE antibody

70R-31054 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 286
Description: Purified Polyclonal Separase antibody

Separase Antibody

AF9195 200ul
EUR 420

Separase Antibody

AF9195-100ul 100ul
EUR 280

Separase Antibody

AF9195-200ul 200ul
EUR 350

Separase Antibody

ABF9195 100 ug
EUR 525.6

SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

SEPARASE (Phospho-Ser801) Colorimetric Cell-Based ELISA Kit

EKC2000 100ul
EUR 686.4

Separase (pS801) Antibody

20-abx134111
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  • 100 ul
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  • 30 ul

Rabbit Polyclonal Separase Antibody

TA309645 100 µl Ask for price

Separase Polyclonal Antibody

ABP52424-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

E20-74243 100ug
EUR 225
Description: Available in various conjugation types.

Separase Conjugated Antibody

C44415 100ul
EUR 476.4

Separase Polyclonal Antibody

E44H02168 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

SEPARASE (Ab-801) Antibody

8B0086 50ug
EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Ab-801) Antibody

E11-0086B 100μg
EUR 225
Description: Available in various conjugation types.

Separase (A795) polyclonal antibody

E43P0374 100ul
EUR 225
Description: Available in various conjugation types.

Separase Rabbit Polyclonal Antibody

ES3423-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Rabbit Polyclonal Antibody

ES3423-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Mouse Monoclonal Separase Antibody (XJ11-4D7)

TA309647 100 µl Ask for price

Polyclonal ESPL1 / Separase Antibody (aa767-816)

APR02989G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

Mouse Monoclonal Separase Antibody (XJ11-1B12)

TA309646 100 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP32216PU-N 50 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP20283PU-N 100 µg Ask for price

Separase Blocking Peptide

20-abx161616
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  • 1 mg
  • 5 mg

Separase Blocking Peptide

AF9195-BP 1mg
EUR 234

SEPARASE Cell ELISA Kit

abx595539-96tests 96 tests
EUR 764.4

SEPARASE Cell ELISA Kit

abx595539-100g 100 µg Ask for price

SEPARASE Cell ELISA Kit

abx595539-10g 10 µg
EUR 493.75

SEPARASE Cell ELISA Kit

abx595539-50g 50 µg Ask for price

Separase (pS801) Blocking Peptide

20-abx162232
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  • 1 mg
  • 5 mg

Separase (ESPL1) pSer1126 rabbit polyclonal antibody, Aff - Purified

AP12707PU-N 400 µl Ask for price

SEPARASE Cell-Based ELISA Kit

EKA50537-5x96T 5x96T
EUR 2122.78

SEPARASE Cell-Based ELISA Kit

EKA50537-96T 96T
EUR 446.9

Separase (ESPL1) (1866-1966) mouse monoclonal antibody, clone XJ11-1B12, Azide Free

AM26568AF-N 100 µg Ask for price

SEPARASE Colorimetric Cell-Based ELISA Kit

EKC1516 100ul
EUR 686.4

SEPARASE Colorimetric Cell-Based ELISA Kit (OKAG01028)

OKAG01028 96 Wells
EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Separin Phospho-Ser801 (ESPL1 pS801) Antibody

20-abx326180
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  • 100 ug
  • 50 ug

Separin Phospho-Ser801 (ESPL1 pS801) Antibody

abx326180-100g 100 µg
EUR 250

Separin Phospho-Ser801 (ESPL1 pS801) Antibody

abx326180-50g 50 µg
EUR 187.5

OAAB16114-400UL - SEPARIN Antibody (Phospho-Ser1126)

OAAB16114-400UL 400ul
EUR 419

SEPARIN (Phospho-Ser1126) Rabbit pAb

E2614972 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-SEPARASE (Ser801) Cell-Based ELISA Kit

EKA51034-192T 192T
EUR 564.5

Phospho-SEPARASE (Ser801) Cell-Based ELISA Kit

EKA51034-5x96T 5x96T Ask for price

Phospho- RIP3 (phospho S232) Antibody

ABF3805 100 ug
EUR 525.6

phospho-Akt1 (Phospho-Ser479) Antibody

12891-100ul 100ul
EUR 302.4

phospho-Akt1 (Phospho-Ser479) Antibody

12891-50ul 50ul
EUR 224.4

phospho-Marcks (phospho-Marcks) Antibody

abx236404-100ug 100 ug
EUR 610.8

phospho-Marcks (phospho-Marcks) Antibody

abx236405-100ug 100 ug
EUR 661.2

Phospho-SEPARASE (Ser801) Colorimetric Cell-Based ELISA Kit (OKAG01525)

OKAG01525 2 x 96 Wells
EUR 888
Description: Description of target: ;Species reactivity: Human: S801, Mouse: S1189;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: Phospho
Detection Method: Colorimetric 450 nm;Sensitivity:

PAK1(Phospho-S144)+PAK2(Phospho-S141)+PAK3(Phospho-S139) Antibody

13363 100ul
EUR 429

PAK1(Phospho-S144)+PAK2(Phospho-S141)+PAK3(Phospho-S139) Antibody

13363-100ul 100ul
EUR 399.6

PAK1(Phospho-S144)+PAK2(Phospho-S141)+PAK3(Phospho-S139) Antibody

13363-50ul 50ul
EUR 286.8

Anti-Myosin phospho S19/phospho S20 Antibody

P11637-1 100uL
EUR 546
Description: Rabbit Polyclonal Myosin phospho S19/phospho S20 Antibody. Validated in IP, WB and tested in Human.

OASL00003-100UL - ERK1 (Phospho-T202/Phospho-Y204) + ERK2 (Phospho-T185/Phospho-Y187) Antibody

OASL00003-100UL 100ul
EUR 269

Erk1(Phospho-T202)+Erk2(Phospho-T185) Antibody

13340 100ul
EUR 429

Erk1(Phospho-T202)+Erk2(Phospho-T185) Antibody

13340-100ul 100ul
EUR 399.6

Erk1(Phospho-T202)+Erk2(Phospho-T185) Antibody

13340-50ul 50ul
EUR 286.8

Phospho-Mst1(Thr183)/Mst2 (Phospho-Thr180) Antibody

Ab17467-100 100ul
EUR 578.4

phospho MBP antibody

10R-P120a 100 ug
EUR 846
Description: Mouse monoclonal phospho MBP antibody

phospho Tau antibody

10R-T102b 100 ug
EUR 1072
Description: Mouse monoclonal phospho Tau antibody

Phospho IRS antibody

10R-6733 100 ug
EUR 781.2
Description: Mouse monoclonal Phospho IRS antibody

Phospho Akt antibody

20R-1507 100 ug
EUR 846
Description: Rabbit polyclonal Phospho Akt antibody

PAK1(Phospho-S144)+PAK2(Phospho-S141)+PAK3(Phospho-S139) Conjugated Antibody

C13363 100ul
EUR 476.4

Anti-Phospho-Separase (S801) antibody

STJ91032 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-Separase (S801).

phospho EGFR antibody

10R-E125a 100 ul
EUR 760
Description: Mouse monoclonal phospho EGFR antibody

IRE1 (Phospho-phospho S724) Antibody

13013-100ul 100ul
EUR 302.4

IRE1 (Phospho-phospho S724) Antibody

13013-50ul 50ul
EUR 224.4

IRE1 (Phospho-phospho Y628) Antibody

13014-100ul 100ul
EUR 302.4

IRE1 (Phospho-phospho Y628) Antibody

13014-50ul 50ul
EUR 224.4

MSK1(Phospho-phospho S376) Antibody

13389 100ul
EUR 429

MSK1(Phospho-phospho S376) Antibody

13389-100ul 100ul
EUR 399.6

MSK1(Phospho-phospho S376) Antibody

13389-50ul 50ul
EUR 286.8

APP (phospho-668) Antibody

20-abx000252
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  • 100 ul
  • 200 ul
  • 50 ul

APP (Phospho-668) Antibody

11190-100ul 100ul
EUR 302.4

APP (Phospho-668) Antibody

11190-50ul 50ul
EUR 224.4

APP (Phospho-668) Antibody

E011190-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

APP (Phospho-668) Antibody

E011190-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Phospho STAT3 antibody

20R-2918 100 ul
EUR 471.6
Description: Rabbit polyclonal Phospho STAT3 antibody

Phospho-Akt Antibody

3257-100 each
EUR 502.8

Phospho-Bad Antibody

3269-100 each
EUR 483.6

Phospho-PKC Antibody

3451-100 each
EUR 483.6

Phospho-Lck Antibody

3499-100 each
EUR 510

Phospho-Raf Antibody

3504-100 each
EUR 510

Phospho-p53 Antibody

3515-100 each
EUR 627.6

Phospho-Tau Antibody

3550R-100 each
EUR 483.6

Phospho-Tau antibody

70R-12468 100 ul
EUR 455
Description: Rabbit polyclonal Phospho Tau antibody

Phospho-Akt antibody

70R-11723 100 ug
EUR 476
Description: Rabbit polyclonal Phospho-Akt antibody

Phospho-Bad antibody

70R-11732 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-Bad antibody

Phospho-AFX antibody

70R-11733 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-AFX antibody

Phospho-MK2 antibody

70R-11823 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-MK2 antibody

Phospho-PKC antibody

70R-11836 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-PKC antibody

Phospho-Lck antibody

70R-11875 100 ug
EUR 483
Description: Rabbit polyclonal Phospho-Lck antibody

Phospho-Raf antibody

70R-11879 100 ug
EUR 483
Description: Rabbit polyclonal Phospho-Raf antibody

Phospho-p53 antibody

70R-11881 100 ug
EUR 609
Description: Rabbit polyclonal Phospho-p53 antibody

Phospho-VASP Antibody

3719-100 each
EUR 483.6

Phospho-NR2B antibody

70R-12472 100 ul
EUR 697.2
Description: Rabbit polyclonal Phospho-NR2B antibody

Phospho-ATF2 antibody

70R-11771 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-ATF2 antibody

Phospho-Elk1 antibody

70R-11792 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-Elk1 antibody

Phospho-SEK1 antibody

70R-11855 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-SEK1 antibody

Phospho-Mek1 antibody

70R-11884 100 ul
EUR 483
Description: Rabbit polyclonal Phospho-Mek1 antibody

Phospho-SAPK antibody

70R-11932 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-SAPK antibody

Phospho-VASP antibody

70R-12031 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-VASP antibody

Histone H1.3 (Phospho-Thr17) +H1.4 (Phospho-Thr17) Antibody

12793-100ul 100ul
EUR 302.4

Histone H1.3 (Phospho-Thr17) +H1.4 (Phospho-Thr17) Antibody

12793-50ul 50ul
EUR 224.4

Goat Anti-EAT2 phospho (Y127) Antibody (Phospho-Specific)

TA305804 100 µg Ask for price

OAAI00711-100UG - Anti-MEK5 Antibody (Phospho-Ser311/ Phospho-Thr315, Phospho-specific)

OAAI00711-100UG 100ug
EUR 449

Ezrin (phospho-T567) /Radixin (phospho-T564) /Moesin (phospho-T558) polyclonal antibody

E43S4717 100ul
EUR 225
Description: Available in various conjugation types.

Phospho Catenin antibody

20R-1543 100 ug
EUR 846
Description: Rabbit polyclonal Phospho beta Catenin antibody

Phospho-BRCA1 Antibody

3674-100 each
EUR 483.6

Phospho-Stat2 Antibody

3469-100 each
EUR 483.6

Phospho-Stat3 Antibody

3474-100 each
EUR 483.6

Phospho-Stat5 Antibody

3475-100 each
EUR 483.6

Phospho-Stat6 Antibody

3476-100 each
EUR 483.6

phospho-CD244 Antibody

abx430952-200ul 200 ul
EUR 460.8

Phospho-ORF50 antibody

70R-13247 100 ul
EUR 550
Description: Affinity purified Rabbit polyclonal Phospho-ORF50 antibody

Phospho-STAT2 antibody

70R-11847 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-STAT2 antibody

Phospho-STAT3 antibody

70R-11852 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-STAT3 antibody

Phospho-STAT5 antibody

70R-11853 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-STAT5 antibody

Phospho-STAT6 antibody

70R-11854 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-STAT6 antibody

Phospho-GSK3b antibody

70R-11870 100 ug
EUR 483
Description: Rabbit polyclonal Phospho-GSK3b antibody

Phospho-BRCA1 antibody

70R-11991 100 ug
EUR 455
Description: Rabbit polyclonal Phospho-BRCA1 antibody

Phospho-CD244 Antibody

R33769-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: NAIL, NKR2B4, Nmrk, SLAMF4

phospho-CD244 Antibody

abx430952-200l 200 µl
EUR 387.5

Phospho-CaMKII Antibody

3384-100 each
EUR 483.6

Phospho-MARCKS Antibody

3650-100 each
EUR 510

Phospho-CAMK2A antibody

70R-11789 100 ul
EUR 455
Description: Rabbit polyclonal Phospho-CAMK2A antibody

We show here that Sister Centromere Biorientation is not enough for “depotek” rec8 in meiosis II in yeast. Instead, our data shows that the Ubiquitin-Ligase APC / CCDC20 removes PP2A from the centromair with targeting Shugoshin SGGO1 degradation and MPS1 kinase. This implies that the rec8 remains protected until it enters the anafase II when diffosphorylation together with the activation of a separase. Here, we provide further support for this model and speculate about the relevance with oocytes of mammals.

Karina

Related Posts

Structure and Function of the Separase-Securin Complex

Structure and Function of the Separase-Securin Complex

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Identification of Bioactive Small Molecule Inhibitors of Separase.

Identification of Bioactive Small Molecule Inhibitors of Separase.

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