Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

Prostate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used treatment for men with prostate cancer, harmful effects can affect patient health and quality of life. Therefore, identifying new target genes for tumor growth will develop new therapeutic intervention. TPX2 plays a vital role in chromosomal segregation machines during mitosis. The low rate of bad chromosomal inserted can promote the development of the tumor, while higher levels could promote cell death and remove tumorigenesis. Therefore, the strategy for promoting cell death by inducing poor massive chromosome unspede has been a selectively eliminating therapeutic application of extremely proliferative tumor cells.

RNAI has been used for the reversal of the expression of TPX2 proteins and a clonogenic dosage, an immunostable block, a double thymidine, an image cytometry analysis and a tumor spheroid test have been used to analyze the role of TPX2 in the Growth of tumor cells, the progression of the cell cycle, the multinaresis, the ploidy, and tumorenicity, respectively; Finally, Western blotting has been used to analyze the anticancer mechanisms in TPX2 targeting. We have demonstrated that targeting reduced cell cycle regulations of TPX2 and chromosomal segregation genes, resulting in increased cell micronuclearization.

In addition, TPX2 exhaustion resulted in an inhibition of the growth of the prostate cancer cell, an increase in apoptosis and reduced tumorigenesis. These results confirmed the therapeutic potential to target TPX2 in the treatment of prostate cancer. In addition, we found that the TPX2 silencer led to the deregulation of CDK1, cyclin B, Securin, separated and arouped a protein; On the other hand, the P21 mRNA has been regulated. We also determined the Molecular TPX2 targeting mechanisms in prostate cancer cells. In conclusion, our study illustrates the power of TPX2 as a new target gene for the treatment of prostate cancer.

 

Synthesis and activity of benzimidazole-1,3-sepaase dioxide inhibitors.

Due to the oncogenic activity of the cohesic protease, separated in human cancer cells, the modulation of an enzymatic separation activity could constitute a new therapeutic strategy to target aneuploid tumors resistant to the overloid. In this, we signal the synthesis, the structural information and the structure-activity structure (SAR) of separate inhibitors based on the modification of the lead molecule 2,2-dimethyl-5-nitro-2h-benzimidazole-1 , 3-dioxide, named sepin -1, (1) identified from a broadband screen.

The replacement of -NO2 to C5 with other functional groups reduced the inhibitory activity in the enzymatic dosage separated. The substitution of the two methyl groups with other C2 alkyl chains moderately improves the effects on the inhibitory activity of these compounds. The modifications of 2h-benzimidazole-1,3-dioxide or skeleton have a variable effect on the inhibition of the enzymatic sepaase activity. The functional theoretical calculations of density (DFT) suggest that there may be a correlation between the loads of the oxide fragments on these compounds and their activity in the inhibition of the sepaase enzyme. The morphogenesis of the plants depends on the synchronized anisotropic expansion of individual cells in response to development and environmental signals.

The magnitude of cell dilation depends on the biomechanical properties of the cell wall, which depends both on its biosynthesis and its extensibility. Although the control of cell expansion by phytohormone Auxin has established, its regulation of the composition of the cell wall, the traffic of the cuases H +, and K + influx which leads to growth is always elucidated. In addition, the maintenance of auxin flows via the interaction between the cytoskeleton and the recycling of the spindle proteins on the plasma membrane remains under study.

 Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.
Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

The release of centrosio and centrosome fragmentation caused by mitotic delays.

The Spindle Assembly (SAC) inspection post postponed mitosis until all female chromatid pairs reached two orientations, and while bags could maintain mitotic capture for an extended period, moderate delay in mitotic development has a significant effect on the cells of the child produced. Here we show that when epithelial cells (RPE1) pigmented retina experiences mitotic delays, there is an increase that depends on the time in centrosome fragmentation and the release of centrole. While most cells with centrioles that are released maintaining spindle bipolarity, the grouping of centriolyes that are released requires Kinesin-14, hset.

The centrosome fragmentation and mature centriol relevance relies on complex / cyclosomom / cyclosomom (APC / c) which triggered, which also triggered the acquisition of distal complementary markers on the child’s centrioly and the loss of procentive markers. Together, these results indicate that moderate delays in mitotic development triggered the initiation of centriol licenses through the release of centriol, at that time the ability to maintain spindle bipolarity into a functions of grouping spindle poles mediated by hset. The cells undergo meiosis produce haploid gamets through one round of DNA replication followed by 2 rounds of chromosome separation.

It requires a cohesin complex, which forms brother chromatid cohesion during phase S, is removed gradually. In Meiosis I, separate proteases triggered a segregation of homologous chromosomes by dividing the rec8 cohesin subunit on the chromosome arm. Cohesin survived at the Centromeres because PP2A Phosphatase, was recruited by Shugoshin’s protein, eliminating Rechosterlate Rec8 and thus protecting it from the cleavage. While chromatid was disinitized in the cleavage of the rec8 centromer in meiosis II, it was not clear how and when the Centromercon Rec8 was released from the PP2A protector. One proposal is that the power of the bipolar spindle separates PP2A from REC8 as a cell in Metaphase II.

 

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF635 0.1mL(AF635)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-005mL 0.05mL
EUR 285

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-01mL 0.1mL
EUR 385

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-5x01mL 5x0.1mL
EUR 1590

Separase (Phospho-Ser801) Antibody

A0086-100ul 100μl
EUR 217
Description: Separase (Phospho-Ser801) Rabbit Polyclonal Antibody

Separase (Phospho-Ser801) Antibody

A0086-50ul 50μl
EUR 143.5
Description: Separase (Phospho-Ser801) Rabbit Polyclonal Antibody

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

E20-60872 100ug
EUR 225
Description: Available in various conjugation types.

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-100ul 100ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-20ul 20ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-50ul 50ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase (phospho Ser801) Polyclonal Antibody

E44H00548 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase (phospho Ser801) Polyclonal Antibody

MBS9242436-01mL 0.1mL
EUR 425

Separase (phospho Ser801) Polyclonal Antibody

MBS9242436-5x01mL 5x0.1mL
EUR 1887

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mg 0.1mg
EUR 305

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF610 0.1mL(AF610)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF635 0.1mL(AF635)
EUR 465

Separase (Phospho-Ser801) Polyclonal Antibody

12353 100ul
EUR 319

Separase (Phospho-Ser801) Polyclonal Antibody

12353-100ul 100ul
EUR 302.4

Separase (Phospho-Ser801) Polyclonal Antibody

12353-50ul 50ul
EUR 224.4

Separase (Phospho-Ser801) Polyclonal Antibody

E012353 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-005mL 0.05mL
EUR 245

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-01mL 0.1mL
EUR 305

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-5x01mL 5x0.1mL
EUR 1230

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Rabbit pAb

E2252078 100ul
EUR 225
Description: Available in various conjugation types.

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mL 0.1mL
EUR 305

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF405L 0.1mL(AF405L)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF405S 0.1mL(AF405S)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF610 0.1mL(AF610)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF635 0.1mL(AF635)
EUR 565

Separase Antibody

20-abx121903
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Separase Antibody

44415-100ul 100ul
EUR 302.4

Separase Antibody

44415-50ul 50ul
EUR 224.4

Separase Antibody

20-abx215242
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  • Ask for price
  • 100 ug
  • 50 ug

Separase Antibody

E18-9195-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Separase Antibody

E18-9195-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

E38PA4405 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE antibody

70R-31054 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 286
Description: Purified Polyclonal Separase antibody

Separase Antibody

AF9195 200ul
EUR 420

Separase Antibody

AF9195-100ul 100ul
EUR 280

Separase Antibody

AF9195-200ul 200ul
EUR 350

Separase Antibody

ABF9195 100ug
EUR 325

Separase Antibody

MBS8582489-01mL 0.1mL
EUR 305

Separase Antibody

MBS8582489-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase Antibody

MBS8582489-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase Antibody

MBS8582489-01mLAF610 0.1mL(AF610)
EUR 465

Separase Antibody

MBS8582489-01mLAF635 0.1mL(AF635)
EUR 465

Separase Antibody

MBS8513234-005mg 0.05mg
EUR 235

Separase Antibody

MBS8513234-01mg 0.1mg
EUR 305

Separase Antibody

MBS8513234-01mLAF405M 0.1mL(AF405M)
EUR 465

Separase Antibody

MBS8513234-01mLAF546 0.1mL(AF546)
EUR 465

Separase Antibody

MBS8513234-01mLAF750 0.1mL(AF750)
EUR 465

Separase Antibody

MBS5316304-01mL 0.1mL
EUR 535

Separase Antibody

MBS5316304-5x01mL 5x0.1mL
EUR 2270

Separase Antibody

MBS9602238-01mL 0.1mL
EUR 260

Separase Antibody

MBS9602238-02mL 0.2mL
EUR 305

Separase Antibody

MBS9602238-5x02mL 5x0.2mL
EUR 1220

SEPARASE Antibody

MBS9503506-005mL 0.05mL
EUR 285

SEPARASE Antibody

MBS9503506-01mL 0.1mL
EUR 385

SEPARASE Antibody

MBS9503506-5x01mL 5x0.1mL
EUR 1590

Separase Antibody

B0086-100ul 100μl
EUR 217
Description: Separase Rabbit Polyclonal Antibody

Separase Antibody

B0086-50ul 50μl
EUR 143.5
Description: Separase Rabbit Polyclonal Antibody

SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

SEPARASE (Phospho-Ser801) Colorimetric Cell-Based ELISA Kit

EKC2000 100ul
EUR 686.4

Separase (pS801) Antibody

20-abx134111
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Rabbit Polyclonal Separase Antibody

TA309645 100 µl Ask for price

Separase Polyclonal Antibody

ABP52424-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

E20-74243 100ug
EUR 225
Description: Available in various conjugation types.

Separase Conjugated Antibody

C44415 100ul
EUR 476.4

Separase Polyclonal Antibody

BT-AP08213-100ul 100ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

BT-AP08213-20ul 20ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

BT-AP08213-50ul 50ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

E44H02168 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase Polyclonal Antibody

MBS9245184-01mL 0.1mL
EUR 415

Separase Polyclonal Antibody

MBS9245184-5x01mL 5x0.1mL
EUR 1841

Separase Polyclonal Antibody

MBS8525224-01mg 0.1mg
EUR 305

Separase Polyclonal Antibody

MBS8525224-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF610 0.1mL(AF610)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF635 0.1mL(AF635)
EUR 465

Separase Polyclonal Antibody

MBS2539051-002mL 0.02mL
EUR 140

Separase Polyclonal Antibody

MBS2539051-006mL 0.06mL
EUR 180

Separase Polyclonal Antibody

MBS2539051-012mL 0.12mL
EUR 260

Separase Polyclonal Antibody

MBS2539051-02mL 0.2mL
EUR 405

Separase Conjugated Antibody

MBS9452367-01mLAF350 0.1mL(AF350)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF405 0.1mL(AF405)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF488 0.1mL(AF488)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF555 0.1mL(AF555)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLBiotin 0.1mL(Biotin)
EUR 480

SEPARASE (Ab-801) Antibody

8B0086 50ug
EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Ab-801) Antibody

E11-0086B 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Ab-801) Antibody

MBS859119-01mg 0.1mg
EUR 305

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF405L 0.1mL(AF405L)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF405S 0.1mL(AF405S)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF610 0.1mL(AF610)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF635 0.1mL(AF635)
EUR 465

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (AP)

MBS6436990-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (AP)

MBS6436990-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (PE)

MBS6437000-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (PE)

MBS6437000-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (APC)

MBS6436991-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (APC)

MBS6436991-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (HRP)

MBS6436994-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (HRP)

MBS6436994-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (FITC)

MBS6436993-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (FITC)

MBS6436993-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (Biotin)

MBS6436992-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (Biotin)

MBS6436992-5x01mL 5x0.1mL
EUR 4120

Separase (A795) polyclonal antibody

E43P0374 100ul
EUR 225
Description: Available in various conjugation types.

Separase Rabbit Polyclonal Antibody

ES3423-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Rabbit Polyclonal Antibody

ES3423-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Mouse Monoclonal Separase Antibody (XJ11-4D7)

TA309647 100 µl Ask for price

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 405)

MBS6436995-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 405)

MBS6436995-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 490)

MBS6436996-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 490)

MBS6436996-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 550)

MBS6436997-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 550)

MBS6436997-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 650)

MBS6436998-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 650)

MBS6436998-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 750)

MBS6436999-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 750)

MBS6436999-5x01mL 5x0.1mL
EUR 4120

Polyclonal ESPL1 / Separase Antibody (aa767-816)

APR02989G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

Mouse Monoclonal Separase Antibody (XJ11-1B12)

TA309646 100 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP32216PU-N 50 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP20283PU-N 100 µg Ask for price

Separase Blocking Peptide

20-abx161616
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  • 1 mg
  • 5 mg

Separase Blocking Peptide

AF9195-BP 1mg
EUR 234

Separase Blocking Peptide

MBS8243371-1mg 1mg
EUR 190

Separase Blocking Peptide

MBS8243371-5mg 5mg
EUR 345

Separase Blocking Peptide

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SEPARASE Cell ELISA Kit

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We show here that Sister Centromere Biorientation is not enough for “depotek” rec8 in meiosis II in yeast. Instead, our data shows that the Ubiquitin-Ligase APC / CCDC20 removes PP2A from the centromair with targeting Shugoshin SGGO1 degradation and MPS1 kinase. This implies that the rec8 remains protected until it enters the anafase II when diffosphorylation together with the activation of a separase. Here, we provide further support for this model and speculate about the relevance with oocytes of mammals.

Karina

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