Day: December 22, 2020

KarinaDecember 22, 2020

Structure and Function of the Separase-Securin Complex

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Structure and Function of the Separase-Securin Complex

Sepaase is a large protease of cysteine in eukaryotes and presents crucial roles in many cell processes, in particular chromosomal…

KarinaDecember 22, 2020

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

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The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

During mitotic prohase, cohesins are removed from the chromosome arms by WAPP to ensure a faithful separation of the Chromatide…

KarinaDecember 22, 2020

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

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Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. SEPIN-1…

KarinaDecember 22, 2020

Identification of Bioactive Small Molecule Inhibitors of Separase.

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Identification of Bioactive Small Molecule Inhibitors of Separase.

Sepased, a cysteine protease of the CD clan, triggers the segregation of chromosome during mitosis by cleaving the cohesine ring…

KarinaDecember 22, 2020

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

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[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

GOAL To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and…

KarinaDecember 22, 2020

Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

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Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.

Prostate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used…