[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

GOAL
To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and spermatogenesis.

Methods AMH CRE positive mice are homozygous for RICTOR LOXP with a specific RICTOR sertoli cell removal have been obtained by AMH CRE cross-high mice with RICTOR LOXP mice. The histology of the reproduction members, seminiferous tubules and the epididymis of transgenic mice were observed with coloring. The germ cell cell subgroups in the seminiferous tubule were detected by flow cytometry with labeling of propidium iodide. Ki 67 and sepaase expression levels were detected with immunofluorescence assay and BTB-associated protein expression levels were detected with immunofluorescence and Western blots.

RESULTS Compared to control (AMH CREF, RICTORLOXP / LOXP or RICTORLOXP / -), SERTOLI specific cell deleting mice has decreased considerably the weight of testicular weight and the epididymium weight (p <0.05), increased by Significantly a significant level of diploid cells (p <0.01) and decreased haploid cells (p <0.01) but comparable tetraploid cells and similar levels of ki 67 and sepaase. The mice with Knockout Ricor also showed an aberrant location of the BTB associated proteins, which were dispersed over the entire seminiferous epithelium, but the expression levels of the protein remained stable.

Conclusions
The testicular sertoli cells are essential for maintaining the integrity and function of BTB and ensuring normal spermatogenesis in the mouse.

MPS1 Kinase dependent on the location of median kinase-dependent centromere Protection of coheche in mice meiosis of mice I.

A main characteristic of meiosis is the removal of step-by-step cohesin of cohesin, the protein complex holding sister chromatids together, first of all weapons in meiosis I and then the centromere region of Méiose II. The centromeric cohesia is protected by SGO2 of sepaase-mediated cleavage, in order to maintain sister chromatids together until they separate from meiosis II. The failures in the elimination of step-by-step cohesic have resulted in aneuploid gametes, thus preventing the generation of healthy embryos.

Here, we note that Kinase activities of Bub1 and MPS1 are needed for SGO2 location in the centromere region. The oocytes treated with the inhibitor of the MPS1 are defective in the protection of centromeric cohesic, while oocytes devoid of a Bub1 kinase activity, which can not be phosphorylate H2A to T121, are not disturbed in the protection of cohesin. As long as MPS1 is functional. The activities MPS1 and Bub1 Kinase respectively locate the SGO2 in the meiosis I preferably at the centromera and the pericentromer, indicating that SGO2 at the centromera is required for protection.in Meiosis I Centromeric Cohesin is protected by SGE2 from the mediation cleavage of Sepase ensuring that sister chromatics are maintained together until they separation in meiosis II.

Here, the authors show that Bub1 and MPS1 Kinase activities are required for SGO2 location in the Centromere area. Sepased, an enzyme that solves the cohesion of sister chromatids during the transition of metaphase-to-anaphase, plays a central role in chromosomal segregation and cell division. Sepased protein, encoded by additional spindle pole bodies such as 1 gene (ESPL1), is overexpressed in many human cancers, including chest, bones, brain and prostate. Sepase is oncogene and overexpression is sufficient to induce mammary tumors in mice. Acute or chronic overexpression of sepaase in the mute glands leads to aneuploidy and tumorigenesis and the inhibition of the enzymatic separation activity decreases the growth of the xenograms of the human chest tumor in the mouse.

 

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].
[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

The related polo-like kinase made determining the distribution of bub1 in meiosis I.

In meiosis I, chromatid brother was arrested by the same pole (mono orientation), and central cohesion protected throughout the anafase. Shugoshin, which is litkromeres depends on the phosphorylation of Histone H2A by Butug Kinase, plays a central role in protecting cohesin meiotic rec8 from separation division. Meiotic Kinetochore Factors Other Keys, Meikin, can regulate cohesion protection, even though the underlying molecular mechanism is still difficult to understand. Here, we showed that MOA1 yeast fission (Meikin), which colleagues with CENP-C during Meiosis I, recruited PLO1 (polo-like kinase) to Kinetochores and Fosforilates SPC7 (KNL1) to accumulate BUB1. As a result, in contrast to the localization of the release of the transient Kinetochore from Mitosis Bub1, Meiother Bub1 survive in Kinetochores to Anafase I. Pond Bub1 Meiotic ensured the protection and protection of strong cohesion in the centromeres by working with Heterocromatin Swi6 protein, which binded and stabilized SGO1.

Furthermore, molecular genetic analysis shows hierarchical regulations of coconaceric cohesion protection by Meikin and Shugoshin which are important to establish special chromosome segregations of meiosis. We provide evidence that the BUB1 regulation specific meiosis is preserved in the mouse. Mamalia Nima-Like Kinase-1 (NEK1) is a multiple specific kinase which is very stated in mouse germ cells during the Iiosis prophase. Losing NEX1 induces cohesin retention on chromosomes in Meiotic prophase I.

Separase Polyclonal Antibody

ES3423-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Polyclonal Antibody

E20-74243 100ug
EUR 225
Description: Available in various conjugation types.

Separase (A795) polyclonal antibody

E43P0374 100ul
EUR 225
Description: Available in various conjugation types.

Rabbit Polyclonal Separase Antibody

TA309645 100 µl Ask for price

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ES1518-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Polyclonal Antibody

ES1518-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Polyclonal Antibody

E20-60872 100ug
EUR 225
Description: Available in various conjugation types.

Separase (Phospho-Ser801) Polyclonal Antibody

12353-100ul 100ul
EUR 302.4

Separase (Phospho-Ser801) Polyclonal Antibody

12353-50ul 50ul
EUR 224.4

Separase (Phospho-Ser801) Polyclonal Antibody

E012353 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Polyclonal ESPL1 / Separase Antibody (aa767-816)

APR02989G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP32216PU-N 50 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP20283PU-N 100 µg Ask for price

Separase (ESPL1) pSer1126 rabbit polyclonal antibody, Aff - Purified

AP12707PU-N 400 µl Ask for price

Separase Antibody

20-abx215242
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Separase Antibody

20-abx121903
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Separase Antibody

44415-100ul 100ul
EUR 302.4

Separase Antibody

44415-50ul 50ul
EUR 224.4

SEPARASE antibody

70R-31054 100 ug
EUR 392.4
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 344.4
Description: Purified Polyclonal Separase antibody

Separase Antibody

ABF9195 100 ug
EUR 525.6

Separase Antibody

E18-9195-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Separase Antibody

E18-9195-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

E38PA4405 100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

AF9195-100ul 100ul
EUR 280

Separase Antibody

AF9195-200ul 200ul
EUR 350

Separase Antibody

AF9195 100ul
EUR 280
Description: Human

Separase (pS801) Antibody

20-abx134111
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 392.4
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

Separase Conjugated Antibody

C44415 100ul
EUR 476.4

SEPARASE (Ab-801) Antibody

E11-0086B 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Ab-801) Antibody

8B0086 50ug
EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Phospho-Ser801) Antibody

E11-0086A 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Phospho-Ser801) Antibody

8A0086 50ug
EUR 368
Description: SEPARASE (Phospho-Ser801) Antibody

Mouse Monoclonal Separase Antibody (XJ11-4D7)

TA309647 100 µl Ask for price

Mouse Monoclonal Separase Antibody (XJ11-1B12)

TA309646 100 µl Ask for price

Separase Blocking Peptide

AF9195-BP 1mg
EUR 234

Separase Blocking Peptide

20-abx161616
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

SEPARASE Cell ELISA Kit

abx595539-96tests 96 tests
EUR 764.4

Separase (pS801) Blocking Peptide

20-abx162232
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

SEPARASE Cell-Based ELISA Kit

EKA50537-5x96T 5x96T
EUR 2122.78

SEPARASE Cell-Based ELISA Kit

EKA50537-96T 96T
EUR 446.9

Separase (phospho Ser801) Rabbit pAb

E2252078 100ul
EUR 225
Description: Available in various conjugation types.

Separase (ESPL1) (1866-1966) mouse monoclonal antibody, clone XJ11-1B12, Azide Free

AM26568AF-N 100 µg Ask for price

SEPARASE Colorimetric Cell-Based ELISA Kit

EKC1516 100ul
EUR 686.4

SEPARASE Colorimetric Cell-Based ELISA Kit (OKAG01028)

OKAG01028 96 Wells
EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

SEPARASE (Phospho-Ser801) Colorimetric Cell-Based ELISA Kit

EKC2000 100ul
EUR 686.4

SEP10 Polyclonal Antibody

ABP60366-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of SEP10 from Human, Mouse, Rat. This SEP10 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEP10 protein at amino acid sequence of 90-170

SEP10 Polyclonal Antibody

ABP60366-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of SEP10 from Human, Mouse, Rat. This SEP10 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEP10 protein at amino acid sequence of 90-170

SEP10 Polyclonal Antibody

ABP60366-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of SEP10 from Human, Mouse, Rat. This SEP10 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEP10 protein at amino acid sequence of 90-170

SEP11 Polyclonal Antibody

ABP60367-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of SEP11 from Human, Mouse, Rat. This SEP11 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEP11 protein at amino acid sequence of 200-280

SEP11 Polyclonal Antibody

ABP60367-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of SEP11 from Human, Mouse, Rat. This SEP11 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEP11 protein at amino acid sequence of 200-280

SEP11 Polyclonal Antibody

ABP60367-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of SEP11 from Human, Mouse, Rat. This SEP11 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEP11 protein at amino acid sequence of 200-280

SEP10 Polyclonal Antibody

ES10196-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against SEP10 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEP10 Polyclonal Antibody

ES10196-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against SEP10 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEP11 Polyclonal Antibody

ES10197-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against SEP11 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEP11 Polyclonal Antibody

ES10197-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against SEP11 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEP10 Polyclonal Antibody

E11-201250 100ug/100ul
EUR 225
Description: Available in various conjugation types.

SEP11 Polyclonal Antibody

E11-201251 100ug/100ul
EUR 225
Description: Available in various conjugation types.

SEPT4 Polyclonal Antibody

27340-100ul 100ul
EUR 302.4

SEPT4 Polyclonal Antibody

27340-50ul 50ul
EUR 224.4

SEPT8 Polyclonal Antibody

28803-100ul 100ul
EUR 302.4

SEPT8 Polyclonal Antibody

28803-50ul 50ul
EUR 224.4

SEPT9 Polyclonal Antibody

31621-100ul 100ul
EUR 302.4

SEPT9 Polyclonal Antibody

31621-50ul 50ul
EUR 224.4

SEPT2 Polyclonal Antibody

A72656
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

SEPP1 Polyclonal Antibody

A57909
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

SEPW1 Polyclonal Antibody

A63406
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

SEPT4 Polyclonal Antibody

ABP60368-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of SEPT4 from Human, Mouse. This SEPT4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEPT4 protein

SEPT4 Polyclonal Antibody

ABP60368-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of SEPT4 from Human, Mouse. This SEPT4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEPT4 protein

SEPT4 Polyclonal Antibody

ABP60368-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of SEPT4 from Human, Mouse. This SEPT4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEPT4 protein

SEPT9 Polyclonal Antibody

ABP60369-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of SEPT9 from Human. This SEPT9 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEPT9 protein

SEPT9 Polyclonal Antibody

ABP60369-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of SEPT9 from Human. This SEPT9 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEPT9 protein

SEPT9 Polyclonal Antibody

ABP60369-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of SEPT9 from Human. This SEPT9 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human SEPT9 protein

SEPT9 Polyclonal Antibody

ES11749-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against SEPT9. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEPT9 Polyclonal Antibody

ES11749-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against SEPT9. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEPT4 Polyclonal Antibody

ES11871-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against SEPT4 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEPT4 Polyclonal Antibody

ES11871-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against SEPT4 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

SEPT9 Polyclonal Antibody

E11-202803 100ug/100ul
EUR 225
Description: Available in various conjugation types.

SEPT4 Polyclonal Antibody

E11-202925 100ug/100ul
EUR 225
Description: Available in various conjugation types.

SEPT1 Polyclonal Antibody

E917471 100ul
EUR 225
Description: Available in various conjugation types.

SEPT8 Polyclonal Antibody

E915011 100ul
EUR 225
Description: Available in various conjugation types.

SEPN1 Polyclonal Antibody

E915012 100ul
EUR 225
Description: Available in various conjugation types.

SEPW1 Polyclonal Antibody

E915014 100ul
EUR 225
Description: Available in various conjugation types.

SEPT3 Polyclonal Antibody

E916551 100ul
EUR 225
Description: Available in various conjugation types.

SEPT5 Polyclonal Antibody

E912953 100ul
EUR 225
Description: Available in various conjugation types.

SEPT7 Polyclonal Antibody

E96883 100ul
EUR 225
Description: Available in various conjugation types.

SEPT6 Polyclonal Antibody

E98196 100ul
EUR 225
Description: Available in various conjugation types.

SEPT2 Polyclonal Antibody

E95801 100ul
EUR 225
Description: Available in various conjugation types.

SEPT12 Polyclonal Antibody

29343-100ul 100ul
EUR 302.4

SEPT12 Polyclonal Antibody

29343-50ul 50ul
EUR 224.4

SEPT12 Polyclonal Antibody

A72733
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

SEPHS1 Polyclonal Antibody

A73644
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

SEPHS1 Polyclonal Antibody

A73645
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

SEPT12 Polyclonal Antibody

E915564 100ul
EUR 225
Description: Available in various conjugation types.

SEPT11 Polyclonal Antibody

E912040 100ul
EUR 225
Description: Available in various conjugation types.

SEPT11 Polyclonal Antibody

E912189 100ul
EUR 225
Description: Available in various conjugation types.

SEPHS1 Polyclonal Antibody

E913403 100ul
EUR 225
Description: Available in various conjugation types.

SEPSECS Polyclonal Antibody

30823-100ul 100ul
EUR 302.4

SEPSECS Polyclonal Antibody

30823-50ul 50ul
EUR 224.4

Seprase Polyclonal Antibody

41425-100ul 100ul
EUR 302.4

Seprase Polyclonal Antibody

41425-50ul 50ul
EUR 224.4

SEPSECS Polyclonal Antibody

A71059
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

Seprase Polyclonal Antibody

ABP54205-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Seprase from Human, Mouse, Rat. This Seprase antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Seprase at AA rangle: 300-380

Seprase Polyclonal Antibody

ABP54205-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Seprase from Human, Mouse, Rat. This Seprase antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Seprase at AA rangle: 300-380

Seprase Polyclonal Antibody

ABP54205-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Seprase from Human, Mouse, Rat. This Seprase antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Seprase at AA rangle: 300-380

SEPSECS Polyclonal Antibody

A52925
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Seprase Polyclonal Antibody

ES5204-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Seprase from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Seprase Polyclonal Antibody

ES5204-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Seprase from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Seprase Polyclonal Antibody

E041425 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Seprase Polyclonal Antibody

E20-74244 100ug
EUR 225
Description: Available in various conjugation types.

Septin 6 (SEPT6) Polyclonal Antibody

CAU22375-100ul 100ul
EUR 235.2

Septin 6 (SEPT6) Polyclonal Antibody

CAU22375-200ul 200ul
EUR 294

Septin 5 (SEPT5) Polyclonal Antibody

CAU22376-100ul 100ul
EUR 235.2

Septin 5 (SEPT5) Polyclonal Antibody

CAU22376-200ul 200ul
EUR 294

Septin 3 Polyclonal Antibody

41426-100ul 100ul
EUR 302.4

Septin 3 Polyclonal Antibody

41426-50ul 50ul
EUR 224.4

Septin 8 Polyclonal Antibody

41427-100ul 100ul
EUR 302.4

Septin 8 Polyclonal Antibody

41427-50ul 50ul
EUR 224.4

Septin 12 Polyclonal Antibody

A66046
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Septin 14 Polyclonal Antibody

ABP54841-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Septin 14 from Human. This Septin 14 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Septin 14 at AA rangle: 310-390

Septin 14 Polyclonal Antibody

ABP54841-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Septin 14 from Human. This Septin 14 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Septin 14 at AA rangle: 310-390

Septin 14 Polyclonal Antibody

ABP54841-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Septin 14 from Human. This Septin 14 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Septin 14 at AA rangle: 310-390

Septin 1 Polyclonal Antibody

ABP52425-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Septin 1 from Human, Mouse, Rat. This Septin 1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Septin 1 at AA range: 150-230

Septin 1 Polyclonal Antibody

ABP52425-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Septin 1 from Human, Mouse, Rat. This Septin 1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Septin 1 at AA range: 150-230

Septin 1 Polyclonal Antibody

ABP52425-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Septin 1 from Human, Mouse, Rat. This Septin 1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Septin 1 at AA range: 150-230

Septin 3 Polyclonal Antibody

ABP52426-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Septin 3 from Human, Mouse, Rat. This Septin 3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Septin 3 at AA range: 110-190

Septin 3 Polyclonal Antibody

ABP52426-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Septin 3 from Human, Mouse, Rat. This Septin 3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Septin 3 at AA range: 110-190

Septin 3 Polyclonal Antibody

ABP52426-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Septin 3 from Human, Mouse, Rat. This Septin 3 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Septin 3 at AA range: 110-190

Septin 7 Polyclonal Antibody

ABP52427-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Septin 7 from Human, Mouse, Rat. This Septin 7 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Septin 7 at AA range: 320-400

Septin 7 Polyclonal Antibody

ABP52427-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Septin 7 from Human, Mouse, Rat. This Septin 7 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Septin 7 at AA range: 320-400

Deposition on time and the elimination of cohesin is very important for accurate chromosome separation. Two processes regulate the removal of cohesin: non-proteolytic mechanism involving wapl, sororin, and PDS5B and direct cleavage with a separase. Here, we showed the role of NEK1 in the WAPL loading regulation during Meiotic Prophase I, through interactions between Nek1 and PDS5b.

Karina

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The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

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Identification of Bioactive Small Molecule Inhibitors of Separase.

Identification of Bioactive Small Molecule Inhibitors of Separase.

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