[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

GOAL
To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and spermatogenesis.

Methods AMH CRE positive mice are homozygous for RICTOR LOXP with a specific RICTOR sertoli cell removal have been obtained by AMH CRE cross-high mice with RICTOR LOXP mice. The histology of the reproduction members, seminiferous tubules and the epididymis of transgenic mice were observed with coloring. The germ cell cell subgroups in the seminiferous tubule were detected by flow cytometry with labeling of propidium iodide. Ki 67 and sepaase expression levels were detected with immunofluorescence assay and BTB-associated protein expression levels were detected with immunofluorescence and Western blots.

RESULTS Compared to control (AMH CREF, RICTORLOXP / LOXP or RICTORLOXP / -), SERTOLI specific cell deleting mice has decreased considerably the weight of testicular weight and the epididymium weight (p <0.05), increased by Significantly a significant level of diploid cells (p <0.01) and decreased haploid cells (p <0.01) but comparable tetraploid cells and similar levels of ki 67 and sepaase. The mice with Knockout Ricor also showed an aberrant location of the BTB associated proteins, which were dispersed over the entire seminiferous epithelium, but the expression levels of the protein remained stable.

Conclusions
The testicular sertoli cells are essential for maintaining the integrity and function of BTB and ensuring normal spermatogenesis in the mouse.

MPS1 Kinase dependent on the location of median kinase-dependent centromere Protection of coheche in mice meiosis of mice I.

A main characteristic of meiosis is the removal of step-by-step cohesin of cohesin, the protein complex holding sister chromatids together, first of all weapons in meiosis I and then the centromere region of Méiose II. The centromeric cohesia is protected by SGO2 of sepaase-mediated cleavage, in order to maintain sister chromatids together until they separate from meiosis II. The failures in the elimination of step-by-step cohesic have resulted in aneuploid gametes, thus preventing the generation of healthy embryos.

Here, we note that Kinase activities of Bub1 and MPS1 are needed for SGO2 location in the centromere region. The oocytes treated with the inhibitor of the MPS1 are defective in the protection of centromeric cohesic, while oocytes devoid of a Bub1 kinase activity, which can not be phosphorylate H2A to T121, are not disturbed in the protection of cohesin. As long as MPS1 is functional. The activities MPS1 and Bub1 Kinase respectively locate the SGO2 in the meiosis I preferably at the centromera and the pericentromer, indicating that SGO2 at the centromera is required for protection.in Meiosis I Centromeric Cohesin is protected by SGE2 from the mediation cleavage of Sepase ensuring that sister chromatics are maintained together until they separation in meiosis II.

Here, the authors show that Bub1 and MPS1 Kinase activities are required for SGO2 location in the Centromere area. Sepased, an enzyme that solves the cohesion of sister chromatids during the transition of metaphase-to-anaphase, plays a central role in chromosomal segregation and cell division. Sepased protein, encoded by additional spindle pole bodies such as 1 gene (ESPL1), is overexpressed in many human cancers, including chest, bones, brain and prostate. Sepase is oncogene and overexpression is sufficient to induce mammary tumors in mice. Acute or chronic overexpression of sepaase in the mute glands leads to aneuploidy and tumorigenesis and the inhibition of the enzymatic separation activity decreases the growth of the xenograms of the human chest tumor in the mouse.

 

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].
[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

The related polo-like kinase made determining the distribution of bub1 in meiosis I.

In meiosis I, chromatid brother was arrested by the same pole (mono orientation), and central cohesion protected throughout the anafase. Shugoshin, which is litkromeres depends on the phosphorylation of Histone H2A by Butug Kinase, plays a central role in protecting cohesin meiotic rec8 from separation division. Meiotic Kinetochore Factors Other Keys, Meikin, can regulate cohesion protection, even though the underlying molecular mechanism is still difficult to understand. Here, we showed that MOA1 yeast fission (Meikin), which colleagues with CENP-C during Meiosis I, recruited PLO1 (polo-like kinase) to Kinetochores and Fosforilates SPC7 (KNL1) to accumulate BUB1. As a result, in contrast to the localization of the release of the transient Kinetochore from Mitosis Bub1, Meiother Bub1 survive in Kinetochores to Anafase I. Pond Bub1 Meiotic ensured the protection and protection of strong cohesion in the centromeres by working with Heterocromatin Swi6 protein, which binded and stabilized SGO1.

Furthermore, molecular genetic analysis shows hierarchical regulations of coconaceric cohesion protection by Meikin and Shugoshin which are important to establish special chromosome segregations of meiosis. We provide evidence that the BUB1 regulation specific meiosis is preserved in the mouse. Mamalia Nima-Like Kinase-1 (NEK1) is a multiple specific kinase which is very stated in mouse germ cells during the Iiosis prophase. Losing NEX1 induces cohesin retention on chromosomes in Meiotic prophase I.

Separase Polyclonal Antibody

BT-AP08213-100ul 100ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

BT-AP08213-20ul 20ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

BT-AP08213-50ul 50ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

E44H02168 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase Polyclonal Antibody

MBS9245184-01mL 0.1mL
EUR 415

Separase Polyclonal Antibody

MBS9245184-5x01mL 5x0.1mL
EUR 1841

Separase Polyclonal Antibody

MBS8525224-01mg 0.1mg
EUR 305

Separase Polyclonal Antibody

MBS8525224-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF610 0.1mL(AF610)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF635 0.1mL(AF635)
EUR 465

Separase Polyclonal Antibody

MBS2539051-002mL 0.02mL
EUR 140

Separase Polyclonal Antibody

MBS2539051-006mL 0.06mL
EUR 180

Separase Polyclonal Antibody

MBS2539051-012mL 0.12mL
EUR 260

Separase Polyclonal Antibody

MBS2539051-02mL 0.2mL
EUR 405

Separase (A795) polyclonal antibody

E43P0374 100ul
EUR 225
Description: Available in various conjugation types.

Separase Rabbit Polyclonal Antibody

ES3423-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Rabbit Polyclonal Antibody

ES3423-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Rabbit Polyclonal Separase Antibody

TA309645 100 µl Ask for price

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

E20-60872 100ug
EUR 225
Description: Available in various conjugation types.

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-100ul 100ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-20ul 20ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-50ul 50ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase (phospho Ser801) Polyclonal Antibody

E44H00548 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase (phospho Ser801) Polyclonal Antibody

MBS9242436-01mL 0.1mL
EUR 425

Separase (phospho Ser801) Polyclonal Antibody

MBS9242436-5x01mL 5x0.1mL
EUR 1887

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mg 0.1mg
EUR 305

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF610 0.1mL(AF610)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF635 0.1mL(AF635)
EUR 465

Separase (Phospho-Ser801) Polyclonal Antibody

12353 100ul
EUR 319

Separase (Phospho-Ser801) Polyclonal Antibody

12353-100ul 100ul
EUR 302.4

Separase (Phospho-Ser801) Polyclonal Antibody

12353-50ul 50ul
EUR 224.4

Separase (Phospho-Ser801) Polyclonal Antibody

E012353 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-005mL 0.05mL
EUR 245

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-01mL 0.1mL
EUR 305

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-5x01mL 5x0.1mL
EUR 1230

Polyclonal ESPL1 / Separase Antibody (aa767-816)

APR02989G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP32216PU-N 50 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP20283PU-N 100 µg Ask for price

Separase (ESPL1) pSer1126 rabbit polyclonal antibody, Aff - Purified

AP12707PU-N 400 µl Ask for price

Separase Antibody

20-abx121903
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  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Separase Antibody

44415-100ul 100ul
EUR 302.4

Separase Antibody

44415-50ul 50ul
EUR 224.4

Separase Antibody

20-abx215242
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Separase Antibody

E18-9195-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Separase Antibody

E18-9195-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

E38PA4405 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE antibody

70R-31054 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 286
Description: Purified Polyclonal Separase antibody

Separase Antibody

AF9195 200ul
EUR 420

Separase Antibody

AF9195-100ul 100ul
EUR 280

Separase Antibody

AF9195-200ul 200ul
EUR 350

Separase Antibody

ABF9195 100ug
EUR 325

Separase Antibody

MBS8582489-01mL 0.1mL
EUR 305

Separase Antibody

MBS8582489-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase Antibody

MBS8582489-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase Antibody

MBS8582489-01mLAF610 0.1mL(AF610)
EUR 465

Separase Antibody

MBS8582489-01mLAF635 0.1mL(AF635)
EUR 465

Separase Antibody

MBS8513234-005mg 0.05mg
EUR 235

Separase Antibody

MBS8513234-01mg 0.1mg
EUR 305

Separase Antibody

MBS8513234-01mLAF405M 0.1mL(AF405M)
EUR 465

Separase Antibody

MBS8513234-01mLAF546 0.1mL(AF546)
EUR 465

Separase Antibody

MBS8513234-01mLAF750 0.1mL(AF750)
EUR 465

Separase Antibody

MBS5316304-01mL 0.1mL
EUR 535

Separase Antibody

MBS5316304-5x01mL 5x0.1mL
EUR 2270

Separase Antibody

MBS9602238-01mL 0.1mL
EUR 260

Separase Antibody

MBS9602238-02mL 0.2mL
EUR 305

Separase Antibody

MBS9602238-5x02mL 5x0.2mL
EUR 1220

SEPARASE Antibody

MBS9503506-005mL 0.05mL
EUR 285

SEPARASE Antibody

MBS9503506-01mL 0.1mL
EUR 385

SEPARASE Antibody

MBS9503506-5x01mL 5x0.1mL
EUR 1590

Separase Antibody

B0086-100ul 100μl
EUR 217
Description: Separase Rabbit Polyclonal Antibody

Separase Antibody

B0086-50ul 50μl
EUR 143.5
Description: Separase Rabbit Polyclonal Antibody

Separase (pS801) Antibody

20-abx134111
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

Separase Conjugated Antibody

C44415 100ul
EUR 476.4

Separase Conjugated Antibody

MBS9452367-01mLAF350 0.1mL(AF350)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF405 0.1mL(AF405)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF488 0.1mL(AF488)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF555 0.1mL(AF555)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLBiotin 0.1mL(Biotin)
EUR 480

SEPARASE (Ab-801) Antibody

8B0086 50ug
EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Ab-801) Antibody

E11-0086B 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Ab-801) Antibody

MBS859119-01mg 0.1mg
EUR 305

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF405L 0.1mL(AF405L)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF405S 0.1mL(AF405S)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF610 0.1mL(AF610)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF635 0.1mL(AF635)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

8A0086 50ug
EUR 368
Description: SEPARASE (Phospho-Ser801) Antibody

SEPARASE (Phospho-Ser801) Antibody

E11-0086A 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mg 0.1mg
EUR 305

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF405L 0.1mL(AF405L)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF405S 0.1mL(AF405S)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF610 0.1mL(AF610)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF635 0.1mL(AF635)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-005mL 0.05mL
EUR 285

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-01mL 0.1mL
EUR 385

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-5x01mL 5x0.1mL
EUR 1590

Separase (Phospho-Ser801) Antibody

A0086-100ul 100μl
EUR 217
Description: Separase (Phospho-Ser801) Rabbit Polyclonal Antibody

Separase (Phospho-Ser801) Antibody

A0086-50ul 50μl
EUR 143.5
Description: Separase (Phospho-Ser801) Rabbit Polyclonal Antibody

Mouse Monoclonal Separase Antibody (XJ11-4D7)

TA309647 100 µl Ask for price

Mouse Monoclonal Separase Antibody (XJ11-1B12)

TA309646 100 µl Ask for price

Separase Blocking Peptide

20-abx161616
  • Ask for price
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  • 1 mg
  • 5 mg

Separase Blocking Peptide

AF9195-BP 1mg
EUR 234

Separase Blocking Peptide

MBS8243371-1mg 1mg
EUR 190

Separase Blocking Peptide

MBS8243371-5mg 5mg
EUR 345

Separase Blocking Peptide

MBS8243371-5x5mg 5x5mg
EUR 1465

Separase Blocking Peptide

MBS9619692-1mg 1mg
EUR 380

Separase Blocking Peptide

MBS9619692-5x1mg 5x1mg
EUR 1650

SEPARASE Cell ELISA Kit

abx595539-96tests 96 tests
EUR 764.4

SEPARASE Cell ELISA Kit

abx595539-100g 100 µg Ask for price

SEPARASE Cell ELISA Kit

abx595539-10g 10 µg
EUR 493.75

SEPARASE Cell ELISA Kit

abx595539-50g 50 µg Ask for price

Separase (pS801) Blocking Peptide

20-abx162232
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Separase (pS801) Blocking Peptide

MBS8209984-1mg 1mg
EUR 230

Separase (pS801) Blocking Peptide

MBS8209984-5mg 5mg
EUR 475

Separase (pS801) Blocking Peptide

MBS8209984-5x5mg 5x5mg
EUR 2060

SEPARASE Cell-Based ELISA Kit

EKA50537-5x96T 5x96T
EUR 2122.78

SEPARASE Cell-Based ELISA Kit

EKA50537-96T 96T
EUR 446.9

SEPARASE Cell-Based ELISA Kit

CB5625 1Kit
EUR 280
Description: SEPARASE Colorimetric Cell-Based ELISA Kit

Separase (phospho Ser801) Rabbit pAb

E2252078 100ul
EUR 225
Description: Available in various conjugation types.

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mL 0.1mL
EUR 305

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF405L 0.1mL(AF405L)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF405S 0.1mL(AF405S)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF610 0.1mL(AF610)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF635 0.1mL(AF635)
EUR 565

Separase (ESPL1) (1866-1966) mouse monoclonal antibody, clone XJ11-1B12, Azide Free

AM26568AF-N 100 µg Ask for price

Deposition on time and the elimination of cohesin is very important for accurate chromosome separation. Two processes regulate the removal of cohesin: non-proteolytic mechanism involving wapl, sororin, and PDS5B and direct cleavage with a separase. Here, we showed the role of NEK1 in the WAPL loading regulation during Meiotic Prophase I, through interactions between Nek1 and PDS5b.

Karina

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The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Identification of Bioactive Small Molecule Inhibitors of Separase.

Identification of Bioactive Small Molecule Inhibitors of Separase.

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