[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

GOAL
To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and spermatogenesis.

Methods AMH CRE positive mice are homozygous for RICTOR LOXP with a specific RICTOR sertoli cell removal have been obtained by AMH CRE cross-high mice with RICTOR LOXP mice. The histology of the reproduction members, seminiferous tubules and the epididymis of transgenic mice were observed with coloring. The germ cell cell subgroups in the seminiferous tubule were detected by flow cytometry with labeling of propidium iodide. Ki 67 and sepaase expression levels were detected with immunofluorescence assay and BTB-associated protein expression levels were detected with immunofluorescence and Western blots.

RESULTS Compared to control (AMH CREF, RICTORLOXP / LOXP or RICTORLOXP / -), SERTOLI specific cell deleting mice has decreased considerably the weight of testicular weight and the epididymium weight (p <0.05), increased by Significantly a significant level of diploid cells (p <0.01) and decreased haploid cells (p <0.01) but comparable tetraploid cells and similar levels of ki 67 and sepaase. The mice with Knockout Ricor also showed an aberrant location of the BTB associated proteins, which were dispersed over the entire seminiferous epithelium, but the expression levels of the protein remained stable.

Conclusions
The testicular sertoli cells are essential for maintaining the integrity and function of BTB and ensuring normal spermatogenesis in the mouse.

MPS1 Kinase dependent on the location of median kinase-dependent centromere Protection of coheche in mice meiosis of mice I.

A main characteristic of meiosis is the removal of step-by-step cohesin of cohesin, the protein complex holding sister chromatids together, first of all weapons in meiosis I and then the centromere region of Méiose II. The centromeric cohesia is protected by SGO2 of sepaase-mediated cleavage, in order to maintain sister chromatids together until they separate from meiosis II. The failures in the elimination of step-by-step cohesic have resulted in aneuploid gametes, thus preventing the generation of healthy embryos.

Here, we note that Kinase activities of Bub1 and MPS1 are needed for SGO2 location in the centromere region. The oocytes treated with the inhibitor of the MPS1 are defective in the protection of centromeric cohesic, while oocytes devoid of a Bub1 kinase activity, which can not be phosphorylate H2A to T121, are not disturbed in the protection of cohesin. As long as MPS1 is functional. The activities MPS1 and Bub1 Kinase respectively locate the SGO2 in the meiosis I preferably at the centromera and the pericentromer, indicating that SGO2 at the centromera is required for protection.in Meiosis I Centromeric Cohesin is protected by SGE2 from the mediation cleavage of Sepase ensuring that sister chromatics are maintained together until they separation in meiosis II.

Here, the authors show that Bub1 and MPS1 Kinase activities are required for SGO2 location in the Centromere area. Sepased, an enzyme that solves the cohesion of sister chromatids during the transition of metaphase-to-anaphase, plays a central role in chromosomal segregation and cell division. Sepased protein, encoded by additional spindle pole bodies such as 1 gene (ESPL1), is overexpressed in many human cancers, including chest, bones, brain and prostate. Sepase is oncogene and overexpression is sufficient to induce mammary tumors in mice. Acute or chronic overexpression of sepaase in the mute glands leads to aneuploidy and tumorigenesis and the inhibition of the enzymatic separation activity decreases the growth of the xenograms of the human chest tumor in the mouse.

 

[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].
[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].

The related polo-like kinase made determining the distribution of bub1 in meiosis I.

In meiosis I, chromatid brother was arrested by the same pole (mono orientation), and central cohesion protected throughout the anafase. Shugoshin, which is litkromeres depends on the phosphorylation of Histone H2A by Butug Kinase, plays a central role in protecting cohesin meiotic rec8 from separation division. Meiotic Kinetochore Factors Other Keys, Meikin, can regulate cohesion protection, even though the underlying molecular mechanism is still difficult to understand. Here, we showed that MOA1 yeast fission (Meikin), which colleagues with CENP-C during Meiosis I, recruited PLO1 (polo-like kinase) to Kinetochores and Fosforilates SPC7 (KNL1) to accumulate BUB1. As a result, in contrast to the localization of the release of the transient Kinetochore from Mitosis Bub1, Meiother Bub1 survive in Kinetochores to Anafase I. Pond Bub1 Meiotic ensured the protection and protection of strong cohesion in the centromeres by working with Heterocromatin Swi6 protein, which binded and stabilized SGO1.

Furthermore, molecular genetic analysis shows hierarchical regulations of coconaceric cohesion protection by Meikin and Shugoshin which are important to establish special chromosome segregations of meiosis. We provide evidence that the BUB1 regulation specific meiosis is preserved in the mouse. Mamalia Nima-Like Kinase-1 (NEK1) is a multiple specific kinase which is very stated in mouse germ cells during the Iiosis prophase. Losing NEX1 induces cohesin retention on chromosomes in Meiotic prophase I.

Separase Polyclonal Antibody

ABP52424-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Antibody

20-abx121903
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Separase Antibody

20-abx215242
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Separase Antibody

44415-100ul 100ul
EUR 252

Separase Antibody

44415-50ul 50ul
EUR 187

Separase Antibody

AF9195 200ul
EUR 304
Description: Separase Antibody detects endogenous levels of total Separase.

Separase Antibody

ABF9195 100 ug
EUR 438

SEPARASE antibody

70R-31054 100 ug
EUR 327
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 287
Description: Purified Polyclonal Separase antibody

Separase (phospho Ser801) Polyclonal Antibody

ES1518-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Polyclonal Antibody

ES1518-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (Phospho-Ser801) Polyclonal Antibody

12353-100ul 100ul
EUR 252

Separase (Phospho-Ser801) Polyclonal Antibody

12353-50ul 50ul
EUR 187

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Anti-Separase Antibody

A04364 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Separase Antibody (ESPL1) detection. Tested with WB, IHC, IF in Human, Mouse.

Separase (pS801) Antibody

20-abx134111
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

Anti-Separase antibody

STJ95608 200 µl
EUR 197
Description: Rabbit polyclonal to Separase.

Separase Conjugated Antibody

C44415 100ul
EUR 397

SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 327
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

Polyclonal ESPL1 / Separase Antibody (aa767-816)

APR02989G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

anti-Separase

YF-PA25396 50 ul
EUR 334
Description: Mouse polyclonal to Separase

Separase Blocking Peptide

20-abx161616
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Separase Blocking Peptide

AF9195-BP 1mg
EUR 195

Anti-Separase (6H6)

YF-MA11199 100 ug
EUR 363
Description: Mouse monoclonal to Separase

Anti-Phospho-Separase (S801) antibody

STJ91032 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-Separase (S801).

SEPARASE Cell ELISA Kit

abx595539-96tests 96 tests
EUR 637

Separase (pS801) Blocking Peptide

20-abx162232
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg

SEPARASE Colorimetric Cell-Based ELISA Kit

EKC1516 100ul
EUR 572

SEPARASE Colorimetric Cell-Based ELISA Kit (OKAG01028)

OKAG01028 96 Wells
EUR 596
Description: Description of target: ;Species reactivity: Human, Mouse;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

SEPARASE (Phospho-Ser801) Colorimetric Cell-Based ELISA Kit

EKC2000 100ul
EUR 572

Phospho-SEPARASE (Ser801) Colorimetric Cell-Based ELISA Kit (OKAG01525)

OKAG01525 2 x 96 Wells
EUR 740
Description: Description of target: ;Species reactivity: Human: S801, Mouse: S1189;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: Phospho
Detection Method: Colorimetric 450 nm;Sensitivity:

Polyclonal AntibodyP3 Polyclonal Antibody

ES6454-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP3 Polyclonal Antibody

ES6454-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP5 Polyclonal Antibody

ES4829-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP5 Polyclonal Antibody

ES4829-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP2 Polyclonal Antibody

ES10016-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP2 Polyclonal Antibody

ES10016-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Polyclonal Antibody

ES10017-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Polyclonal Antibody

ES10017-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Polyclonal Antibody

ES11752-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Polyclonal Antibody

ES11752-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal ZMYND8 polyclonal antibody

AMM08559G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ZMYND8 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal PML polyclonal antibody

AMR09397G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PML polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal PPARG polyclonal antibody

AMR09459G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PPARG polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal PPARG polyclonal antibody

AMR09486G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PPARG polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal MeCP2 polyclonal antibody

AMM06350G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal MeCP2 polyclonal antibody

AMM06351G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal ACTL6B polyclonal antibody

AMM05547G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ACTL6B polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JARID2 polyclonal antibody

AMM06027G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JARID2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal PADI4 polyclonal antibody

APR08916G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PADI4 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Rtf1 polyclonal antibody

APR11187G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Rtf1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Rtf1 polyclonal antibody

APR11188G 0.1ml
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Rtf1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal AKR1B10 Polyclonal Antibody

APG01659G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AKR1B10 Polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal RARA polyclonal antibody

APR00370G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RARA polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal ETO polyclonal antibody

APR00372G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ETO polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal EzH2 polyclonal antibody

APR00373G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EzH2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BRD2 polyclonal antibody

APR00374G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD2c polyclonal antibody

APR00375G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BMI1 polyclonal antibody

APR00376G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMI1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal SHH Polyclonal Antibody

APR00434G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SHH Polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal ETO polyclonal antibody

APR00435G 0.1ml
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ETO polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal EZH2 polyclonal antibody

APR00436G 0.1ml
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EZH2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal RARA polyclonal antibody

APR00437G 0.1ml
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RARA polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal MYH11 polyclonal antibody

APR00438G 0.1ml
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYH11 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal EZH2 polyclonal antibody

APR00439G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EZH2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal p53K372me1 polyclonal antibody

APR00440G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human p53K372me1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal CIITA polyclonal antibody

APR00442G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CIITA polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal p53 polyclonal antibody

APR00443G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human p53 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal CHD4 polyclonal antibody

APR00444G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CHD4 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal HDAC1 polyclonal antibody

APR00445G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HDAC1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Spt16 polyclonal antibody

APR00446G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Spt16 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BRD2 polyclonal antibody

APR00447G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal G9a polyclonal antibody

APR00448G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human G9a polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Hira polyclonal antibody

APR00449G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Hira polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JMJD2c polyclonal antibody

APR00450G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal SPI1 polyclonal antibody

APR00451G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SPI1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BCL7C polyclonal antibody

APR00452G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BCL7C polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal LRWD1 polyclonal antibody

APR00455G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LRWD1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal LYDG10 polyclonal antibody

APR00456G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LYDG10 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal BMI1 polyclonal antibody

APR00457G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMI1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal KDM4D polyclonal antibody

APR00458G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KDM4D polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal CHD4 polyclonal antibody

APR00459G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CHD4 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Spt16 polyclonal antibody

APR00460G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Spt16 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal JARID2 polyclonal antibody

APR12450G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JARID2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Med26 polyclonal antibody

APR12517G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Med26 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Med26 polyclonal antibody

APR12518G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Med26 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal MeCP2 polyclonal antibody

APR12525G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal MeCP2 polyclonal antibody

APR12526G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal MeCP2 polyclonal antibody

APR12527G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal SOX4 polyclonal antibody

APR13475G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SOX4 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal YY1 polyclonal antibody

APR14018G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human YY1 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal PIWIL2 polyclonal antibody

APR17846G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PIWIL2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal FKBP51 polyclonal antibody

APR15992G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FKBP51 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal TGF-beta3 Polyclonal Antibody

APG00008G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human TGF-beta3 Polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal sRANK Ligand Polyclonal Antibody

APR00294G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human sRANK Ligand Polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal FGF-1 Polyclonal Antibody

APR00423G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-1 Polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal RFX-AP polyclonal antibody

APR00441G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RFX-AP polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal EIF2C1/2 polyclonal antibody

APR00453G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EIF2C1/2 polyclonal . This antibody is tested and proven to work in the following applications:

Polyclonal Smc3K112/113ac polyclonal antibody

APR00454G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Smc3K112/113ac polyclonal . This antibody is tested and proven to work in the following applications:

AmCyan Polyclonal Antibody

1-CSB-PA000368
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AmCyan Polyclonal. Recognizes AmCyan Polyclonal from N/A. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000

BFP Polyclonal Antibody

1-CSB-PA000369
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against BFP Polyclonal. Recognizes BFP Polyclonal from N/A. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000

mStrawberry Polyclonal Antibody

1-CSB-PA000370
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against mStrawberry Polyclonal. Recognizes mStrawberry Polyclonal from N/A. This antibody is Unconjugated. Tested in the following application: WB;WB:1:5000

Rubisco Polyclonal Antibody

1-CSB-PA000372
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Rubisco Polyclonal. Recognizes Rubisco Polyclonal from Various Plants. This antibody is Unconjugated. Tested in the following application: WB;WB:1:3000-5000

WIP Polyclonal Antibody

ES7514-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against WIP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

WIP Polyclonal Antibody

ES7514-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against WIP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

XRCC3 Polyclonal Antibody

ES7519-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against XRCC3 from Human. This antibody is tested and validated for IHC, IF, WB, ELISA

XRCC3 Polyclonal Antibody

ES7519-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against XRCC3 from Human. This antibody is tested and validated for IHC, IF, WB, ELISA

PBF Polyclonal Antibody

ES7537-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PBF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PBF Polyclonal Antibody

ES7537-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PBF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

KOX4 Polyclonal Antibody

ES7540-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against KOX4 from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA

KOX4 Polyclonal Antibody

ES7540-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against KOX4 from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA

ZNF23 Polyclonal Antibody

ES7541-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ZNF23 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

ZNF23 Polyclonal Antibody

ES7541-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ZNF23 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

ZNF76 Polyclonal Antibody

ES7545-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ZNF76 from Human. This antibody is tested and validated for IHC, WB, ELISA

ZNF76 Polyclonal Antibody

ES7545-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ZNF76 from Human. This antibody is tested and validated for IHC, WB, ELISA

EFP Polyclonal Antibody

ES7547-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against EFP from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

EFP Polyclonal Antibody

ES7547-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against EFP from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

ZNF232 Polyclonal Antibody

ES7549-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ZNF232 from Human. This antibody is tested and validated for IHC, WB, ELISA

ZNF232 Polyclonal Antibody

ES7549-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ZNF232 from Human. This antibody is tested and validated for IHC, WB, ELISA

ZP2 Polyclonal Antibody

ES7553-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ZP2 from Human. This antibody is tested and validated for IHC, WB, ELISA

ZP2 Polyclonal Antibody

ES7553-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ZP2 from Human. This antibody is tested and validated for IHC, WB, ELISA

DDR1 Polyclonal Antibody

ES7555-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against DDR1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

DDR1 Polyclonal Antibody

ES7555-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against DDR1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cacna2d1 Polyclonal Antibody

ES7556-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Cacna2d1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cacna2d1 Polyclonal Antibody

ES7556-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Cacna2d1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

CAD Polyclonal Antibody

ES7564-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against CAD from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

CAD Polyclonal Antibody

ES7564-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against CAD from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

TRAPPC6A Polyclonal Antibody

ES7565-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against TRAPPC6A from Human. This antibody is tested and validated for IHC, WB, ELISA

TRAPPC6A Polyclonal Antibody

ES7565-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against TRAPPC6A from Human. This antibody is tested and validated for IHC, WB, ELISA

FKRP Polyclonal Antibody

ES7567-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against FKRP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

FKRP Polyclonal Antibody

ES7567-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against FKRP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

DHRS11 Polyclonal Antibody

ES7568-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against DHRS11 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA, WB, ELISA

Deposition on time and the elimination of cohesin is very important for accurate chromosome separation. Two processes regulate the removal of cohesin: non-proteolytic mechanism involving wapl, sororin, and PDS5B and direct cleavage with a separase. Here, we showed the role of NEK1 in the WAPL loading regulation during Meiotic Prophase I, through interactions between Nek1 and PDS5b.

Karina

Related Posts

Structure and Function of the Separase-Securin Complex

Structure and Function of the Separase-Securin Complex

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Identification of Bioactive Small Molecule Inhibitors of Separase.

Identification of Bioactive Small Molecule Inhibitors of Separase.

No Comment

Leave a Reply

Your email address will not be published.

December 2022
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  

Tags

Recent Posts

Categories