Structure and Function of the Separase-Securin Complex
Sepaase is a large protease of cysteine in eukaryotes and presents crucial roles in many cell processes, in particular chromosomal…
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The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.
During mitotic prohase, cohesins are removed from the chromosome arms by WAPP to ensure a faithful separation of the Chromatide…
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Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.
Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. SEPIN-1…
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Identification of Bioactive Small Molecule Inhibitors of Separase.
Sepased, a cysteine protease of the CD clan, triggers the segregation of chromosome during mitosis by cleaving the cohesine ring…
Read More![[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].](https://separase.com/wp-content/uploads/2020/12/IMG-20201217-WA0088-780x600.jpg)
[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].
GOAL To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and…
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Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.
Prostate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used…
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Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
ESPL1 / separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. aberrant expression…
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Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of…
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Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Separase, a cysteine endopeptidase, are key players in the mitotic sister chromatid separation, the dynamics of the replication fork, and…
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