Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

Separase, a cysteine ​​endopeptidase, are key players in the mitotic sister chromatid separation, the dynamics of the replication fork, and DNA repair. aberrant expression and / or modified separase proteolytic activity associated with aneuploidy, tumorigenesis, and progression of the disease. Due to genomic instability and clonal evolution of the hallmarks of the progress of chronic myeloid leukemia (CML), we have relatively examined separase proteolytic activity in TKI-treated chronic phase CML.

Separase proteolytic activity was analyzed at the single cell level in 88 clinical samples and in 14 healthy controls by flow cytometric assay. In parallel, the BCR-ABL1 gene expression and replication fork velocity was measured by qRT-PCR and DNA tests fiber, respectively. Separase Activity Distribution (SAD) value that indicates the occurrence separase MNC with increased proteolytic activity in the samples found to be positively correlated with BCR-ABL1 gene expression levels and the loss of MMR (relapses) throughout the routine monitoring of BCR-ABL1.

Analysis of CD34 + cells and MNC fractionated by flow cytometric cell sorting according to their level of activity separase (H- and L-fraction) revealed that the CD34 + cells with high activity levels separase (H-fraction) displayed increased proliferation / survival when compared with with normal cells (L-fraction) separase activity (average 3.3-fold, p = 0.0011). BCR-ABL1 positive effect gene expression in MNC H-fractions over L-fraction (42% vs. 8%, respectively).

In addition, expanded CD34 + cells from H-fraction showed a decrease in the speed of replication forks compared to cells L-fraction (p <0.0001). Our data show an association between high activity separase, the rest of the BCR-ABL1 gene expression, and increased capacity for proliferation in hematopoietic cells in leukemia niche TKI-treated chronic phase CML.

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

The data set on Separase-Sepin Inhibitor-1 toxicity in organ weights, hematology and clinical parameters in mice Sprague Dawley-.

Separase-Sepin Inhibitor-1 has shown great promise as a chemotherapeutic agent to treat Separase development-overexpressing tumors, however, very little is known about the toxicity profile. Here we present data set organ weights, hematology and clinical chemistry parameters in Sepin-1-treated rats Sprague Dawley-.

The data set is generated from two groups-Main Study Recovery Study and Study, life duration, in 29 and 57 days, respectively. Mice in both groups were covered with 0, 5, 10 and 20 mg / kg Sepin-1 once a day for 28 consecutive days. Blood samples from mice in the Main Study their organs were collected and weighed on day 29. The animals in the study were in a dose Recovery-off period of 28 days after being treated with Sepin-1 for 28 days, and samples of their blood and organ weight data were collected on day 57.

The mice’s body weights in both the Main and Recovery Study is collected twice a week. hematological parameters of samples of whole blood, such as hemoglobin concentration, platelet count and blood cells, etc., are determined. clinical chemistry parameters of serum, such as albumin concentration, glucose, cholesterol, triglycerides, alanine / aspartate aminotransferase, etc., are measured. Further analysis may yield useful information on the toxicity of Sepin-1 in Rat Sprague Dawley-. The data presented here relate to a research article entitled “Toxicity studies separase-Sepin inhibitor-1 in mice Sprague-Dowley”, available in Pathology – Research and Practice Journal

Separase Antibody

E38PA4405 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE antibody

70R-31054 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 286
Description: Purified Polyclonal Separase antibody

Separase Antibody

AF9195 200ul
EUR 420

Separase Antibody

AF9195-100ul 100ul
EUR 280

Separase Antibody

AF9195-200ul 200ul
EUR 350

Separase Antibody

ABF9195 100ug
EUR 325

Separase Antibody

MBS8582489-01mL 0.1mL
EUR 305

Separase Antibody

MBS8582489-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase Antibody

MBS8582489-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase Antibody

MBS8582489-01mLAF610 0.1mL(AF610)
EUR 465

Separase Antibody

MBS8582489-01mLAF635 0.1mL(AF635)
EUR 465

Separase Antibody

MBS8513234-005mg 0.05mg
EUR 235

Separase Antibody

MBS8513234-01mg 0.1mg
EUR 305

Separase Antibody

MBS8513234-01mLAF405M 0.1mL(AF405M)
EUR 465

Separase Antibody

MBS8513234-01mLAF546 0.1mL(AF546)
EUR 465

Separase Antibody

MBS8513234-01mLAF750 0.1mL(AF750)
EUR 465

Separase Antibody

MBS5316304-01mL 0.1mL
EUR 535

Separase Antibody

MBS5316304-5x01mL 5x0.1mL
EUR 2270

Separase Antibody

MBS9602238-01mL 0.1mL
EUR 260

Separase Antibody

MBS9602238-02mL 0.2mL
EUR 305

Separase Antibody

MBS9602238-5x02mL 5x0.2mL
EUR 1220

SEPARASE Antibody

MBS9503506-005mL 0.05mL
EUR 285

SEPARASE Antibody

MBS9503506-01mL 0.1mL
EUR 385

SEPARASE Antibody

MBS9503506-5x01mL 5x0.1mL
EUR 1590

Separase Antibody

B0086-100ul 100μl
EUR 217
Description: Separase Rabbit Polyclonal Antibody

Separase Antibody

B0086-50ul 50μl
EUR 143.5
Description: Separase Rabbit Polyclonal Antibody

SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

Separase (pS801) Antibody

20-abx134111
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Rabbit Polyclonal Separase Antibody

TA309645 100 µl Ask for price

Separase Polyclonal Antibody

ABP52424-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

E20-74243 100ug
EUR 225
Description: Available in various conjugation types.

Separase Conjugated Antibody

C44415 100ul
EUR 476.4

Separase Polyclonal Antibody

BT-AP08213-100ul 100ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

BT-AP08213-20ul 20ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

BT-AP08213-50ul 50ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Separase Polyclonal Antibody

E44H02168 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase Polyclonal Antibody

MBS9245184-01mL 0.1mL
EUR 415

Separase Polyclonal Antibody

MBS9245184-5x01mL 5x0.1mL
EUR 1841

Separase Polyclonal Antibody

MBS8525224-01mg 0.1mg
EUR 305

Separase Polyclonal Antibody

MBS8525224-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF610 0.1mL(AF610)
EUR 465

Separase Polyclonal Antibody

MBS8525224-01mLAF635 0.1mL(AF635)
EUR 465

Separase Polyclonal Antibody

MBS2539051-002mL 0.02mL
EUR 140

Separase Polyclonal Antibody

MBS2539051-006mL 0.06mL
EUR 180

Separase Polyclonal Antibody

MBS2539051-012mL 0.12mL
EUR 260

Separase Polyclonal Antibody

MBS2539051-02mL 0.2mL
EUR 405

Separase Conjugated Antibody

MBS9452367-01mLAF350 0.1mL(AF350)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF405 0.1mL(AF405)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF488 0.1mL(AF488)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLAF555 0.1mL(AF555)
EUR 480

Separase Conjugated Antibody

MBS9452367-01mLBiotin 0.1mL(Biotin)
EUR 480

SEPARASE (Ab-801) Antibody

8B0086 50ug
EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Ab-801) Antibody

E11-0086B 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Ab-801) Antibody

MBS859119-01mg 0.1mg
EUR 305

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF405L 0.1mL(AF405L)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF405S 0.1mL(AF405S)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF610 0.1mL(AF610)
EUR 465

SEPARASE (Ab-801) Antibody

MBS859119-01mLAF635 0.1mL(AF635)
EUR 465

Separase (A795) polyclonal antibody

E43P0374 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE (Phospho-Ser801) Antibody

8A0086 50ug
EUR 368
Description: SEPARASE (Phospho-Ser801) Antibody

SEPARASE (Phospho-Ser801) Antibody

E11-0086A 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mg 0.1mg
EUR 305

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF405L 0.1mL(AF405L)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF405S 0.1mL(AF405S)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF610 0.1mL(AF610)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS8509363-01mLAF635 0.1mL(AF635)
EUR 465

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-005mL 0.05mL
EUR 285

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-01mL 0.1mL
EUR 385

SEPARASE (Phospho-Ser801) Antibody

MBS9502392-5x01mL 5x0.1mL
EUR 1590

Separase (Phospho-Ser801) Antibody

A0086-100ul 100μl
EUR 217
Description: Separase (Phospho-Ser801) Rabbit Polyclonal Antibody

Separase (Phospho-Ser801) Antibody

A0086-50ul 50μl
EUR 143.5
Description: Separase (Phospho-Ser801) Rabbit Polyclonal Antibody

Separase Rabbit Polyclonal Antibody

ES3423-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Rabbit Polyclonal Antibody

ES3423-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Mouse Monoclonal Separase Antibody (XJ11-4D7)

TA309647 100 µl Ask for price

Polyclonal ESPL1 / Separase Antibody (aa767-816)

APR02989G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ESPL1 / Separase (aa767-816). This antibody is tested and proven to work in the following applications:

Mouse Monoclonal Separase Antibody (XJ11-1B12)

TA309646 100 µl Ask for price

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

ABP50519-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase phospho Ser801) from Human, Mouse. This Separase phospho Ser801) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the phosphorylation site of S801

Separase (phospho Ser801) Polyclonal Antibody

E20-60872 100ug
EUR 225
Description: Available in various conjugation types.

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-100ul 100ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-20ul 20ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase(Phospho Ser801) Polyclonal Antibody

BT-AP07944-50ul 50ul Ask for price
Description: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1| or separase| which initiates the final separation of sister chromatids (Sun et al.| 2009

Separase (phospho Ser801) Polyclonal Antibody

E44H00548 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Separase (phospho Ser801) Polyclonal Antibody

MBS9242436-01mL 0.1mL
EUR 425

Separase (phospho Ser801) Polyclonal Antibody

MBS9242436-5x01mL 5x0.1mL
EUR 1887

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mg 0.1mg
EUR 305

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF405L 0.1mL(AF405L)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF405S 0.1mL(AF405S)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF610 0.1mL(AF610)
EUR 465

Separase (phospho Ser801) Polyclonal Antibody

MBS8520646-01mLAF635 0.1mL(AF635)
EUR 465

Separase (Phospho-Ser801) Polyclonal Antibody

12353 100ul
EUR 319

Separase (Phospho-Ser801) Polyclonal Antibody

12353-100ul 100ul
EUR 302.4

Separase (Phospho-Ser801) Polyclonal Antibody

12353-50ul 50ul
EUR 224.4

Separase (Phospho-Ser801) Polyclonal Antibody

E012353 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-005mL 0.05mL
EUR 245

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-01mL 0.1mL
EUR 305

Separase (Phospho-Ser801) Polyclonal Antibody

MBS9402034-5x01mL 5x0.1mL
EUR 1230

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (phospho Ser801) Rabbit Polyclonal Antibody

ES1518-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase (phospho Ser801) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP32216PU-N 50 µl Ask for price

Separase (ESPL1) rabbit polyclonal antibody, Aff - Purified

AP20283PU-N 100 µg Ask for price

Separase (ESPL1) pSer1126 rabbit polyclonal antibody, Aff - Purified

AP12707PU-N 400 µl Ask for price

Separase Blocking Peptide

20-abx161616
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Separase Blocking Peptide

AF9195-BP 1mg
EUR 234

Separase Blocking Peptide

MBS8243371-1mg 1mg
EUR 190

Separase Blocking Peptide

MBS8243371-5mg 5mg
EUR 345

Separase Blocking Peptide

MBS8243371-5x5mg 5x5mg
EUR 1465

Separase Blocking Peptide

MBS9619692-1mg 1mg
EUR 380

Separase Blocking Peptide

MBS9619692-5x1mg 5x1mg
EUR 1650

SEPARASE Cell ELISA Kit

abx595539-96tests 96 tests
EUR 764.4

SEPARASE Cell ELISA Kit

abx595539-100g 100 µg Ask for price

SEPARASE Cell ELISA Kit

abx595539-10g 10 µg
EUR 493.75

SEPARASE Cell ELISA Kit

abx595539-50g 50 µg Ask for price

Separase (pS801) Blocking Peptide

20-abx162232
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Separase (pS801) Blocking Peptide

MBS8209984-1mg 1mg
EUR 230

Separase (pS801) Blocking Peptide

MBS8209984-5mg 5mg
EUR 475

Separase (pS801) Blocking Peptide

MBS8209984-5x5mg 5x5mg
EUR 2060

Separase (ESPL1) (1866-1966) mouse monoclonal antibody, clone XJ11-1B12, Azide Free

AM26568AF-N 100 µg Ask for price

SEPARASE Cell-Based ELISA Kit

EKA50537-5x96T 5x96T
EUR 2122.78

SEPARASE Cell-Based ELISA Kit

EKA50537-96T 96T
EUR 446.9

SEPARASE Cell-Based ELISA Kit

CB5625 1Kit
EUR 280
Description: SEPARASE Colorimetric Cell-Based ELISA Kit

Separase (phospho Ser801) Rabbit pAb

E2252078 100ul
EUR 225
Description: Available in various conjugation types.

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mL 0.1mL
EUR 305

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF405L 0.1mL(AF405L)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF405S 0.1mL(AF405S)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF610 0.1mL(AF610)
EUR 565

Separase (Phospho Ser801) Rabbit pAb

MBS8540676-01mLAF635 0.1mL(AF635)
EUR 565

SEPARASE Colorimetric Cell-Based ELISA Kit

EKC1516 100ul
EUR 686.4

SEPARASE Colorimetric Cell-Based ELISA Kit

MBS9500539-1x96Wells 1x96Wells
EUR 500

SEPARASE Colorimetric Cell-Based ELISA Kit

MBS9500539-5x96Wells 5x96Wells
EUR 2300

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (AP)

MBS6436990-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (AP)

MBS6436990-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (PE)

MBS6437000-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (PE)

MBS6437000-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (APC)

MBS6436991-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (APC)

MBS6436991-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (HRP)

MBS6436994-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (HRP)

MBS6436994-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (FITC)

MBS6436993-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (FITC)

MBS6436993-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (Biotin)

MBS6436992-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (Biotin)

MBS6436992-5x01mL 5x0.1mL
EUR 4120

SEPARASE Colorimetric Cell-Based ELISA Kit (OKAG01028)

OKAG01028 96 Wells
EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 405)

MBS6436995-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 405)

MBS6436995-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 490)

MBS6436996-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 490)

MBS6436996-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 550)

MBS6436997-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 550)

MBS6436997-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 650)

MBS6436998-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 650)

MBS6436998-5x01mL 5x0.1mL
EUR 4120

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 750)

MBS6436999-01mL 0.1mL
EUR 950

Separase, Phosphorylated (S1126) (ESPL1, ESP1, SEPA) (MaxLight 750)

MBS6436999-5x01mL 5x0.1mL
EUR 4120

SEPARASE (Phospho-Ser801) Colorimetric Cell-Based ELISA Kit

EKC2000 100ul
EUR 686.4

Separase, phosphorylated (Ser748) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS628478-02mL 0.2mL
EUR 695

Separase, phosphorylated (Ser748) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS628478-5x02mL 5x0.2mL
EUR 2975

Separin, phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS623967-02mL 0.2mL
EUR 695

Separin, phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS623967-5x02mL 5x0.2mL
EUR 2975

Separase, Phosphorylated (Ser748) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (AP)

MBS6498923-02mL 0.2mL
EUR 980

Separase, Phosphorylated (Ser748) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (AP)

MBS6498923-5x02mL 5x0.2mL
EUR 4250

Separase, Phosphorylated (Ser748) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (PE)

MBS6498933-02mL 0.2mL
EUR 980

Separase, Phosphorylated (Ser748) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (PE)

MBS6498933-5x02mL 5x0.2mL
EUR 4250

Separin, Phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (AP)

MBS6498934-02mL 0.2mL
EUR 980

Separin, Phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (AP)

MBS6498934-5x02mL 5x0.2mL
EUR 4250

Separin, Phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (PE)

MBS6498944-02mL 0.2mL
EUR 980

Separin, Phosphorylated (Ser801) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (PE)

MBS6498944-5x02mL 5x0.2mL
EUR 4250

Separase, phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS629046-02mL 0.2mL
EUR 695

Separase, phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS629046-5x02mL 5x0.2mL
EUR 2975

Separin, phosphorylated (Ser1501) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS627880-02mL 0.2mL
EUR 695

Separin, phosphorylated (Ser1501) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS627880-5x02mL 5x0.2mL
EUR 2975

Separin, phosphorylated (Ser1126) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS628748-02mL 0.2mL
EUR 695

Separin, phosphorylated (Ser1126) (ESPL1, Separase, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165)

MBS628748-5x02mL 5x0.2mL
EUR 2975

Separase, Phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (AP)

MBS6498912-02mL 0.2mL
EUR 980

Separase, Phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (AP)

MBS6498912-5x02mL 5x0.2mL
EUR 4250

Separase, Phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (APC)

MBS6498913-02mL 0.2mL
EUR 980

Separase, Phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (APC)

MBS6498913-5x02mL 5x0.2mL
EUR 4250


Separase, a sister chromatid cohesion enzyme-finish, is an oncogene and is expressed in many human cancers. Sepin-1 (2,2-dimethyl-5-nitro-2H-benzimidazole-1,3-dioxide) is a potent inhibitor Separase which inhibit cancer cell growth, cell migration and wound healing, indicating that Sepin-1 has a great potential with a target separase-overexpressing tumors.

Karina

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