The FitAmp General Tissue Section DNA Isolation Kit is a comprehensive set of essential components that enables researchers to efficiently…Read More
The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.
During mitotic prohase, cohesins are removed from the chromosome arms by WAPP to ensure a faithful separation of the Chromatide…Read More
Identification of Bioactive Small Molecule Inhibitors of Separase.
Sepased, a cysteine protease of the CD clan, triggers the segregation of chromosome during mitosis by cleaving the cohesine ring…Read More
[RICTOR / MTORC2 regulates the barrier of chronology and spermatogenesis in mice].
GOAL To investigate the role of ricter / MTTORC2 in the formation of the anti-chirmer barrier (BTB), testicular development and…Read More
Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.
Prostate cancer is a complex disease that can be relatively harmless or extremely aggressive. Although androgen-deprivation therapy is commonly used…Read More
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
ESPL1 / separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. aberrant expression…Read More
Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of…Read More
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Separase, a cysteine endopeptidase, are key players in the mitotic sister chromatid separation, the dynamics of the replication fork, and…Read More