Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, here we have profiled toxicity Sepin-1 in mice Sprague-Dawley in setting good laboratory practice (GLP). The maximum tolerated dose (MTD) of Sepin-1 in mice is 40 mg / kg in a single dose study and 20 mg / kg dose study for 7 days in a row.

Toxicity study consists of two parts-Main Study and Restoration Study. Sepin-1 to 0 (control), 5 (low dose), 10 (median dose), and 20 (high dose) mg / kg given by bolus intravenous injection to mice once a day for 28 consecutive days. The animals were euthanized at the Main Study Day 29, whereas in the study animals were allowed to recover Recovery for 28 days after 28 days Sepin-1 dose before they were euthanized on Day 29 of the off-dose periods.

Although the effects of Sepin-1 in low and median doses were minimal, hematological analysis shows that high doses of Sepin-1 associated with a decrease in red blood cells and hemoglobin, and an increase in the number of reticulocytes and platelets and mean corpuscular volume. Clinical chemistry showed that Sepin-1 causes increases in total bilirubin and a decrease in creatine kinase. histopathological analysis showed Sepin-1 results in minimal bone marrow erythroid hyperplasia, minimal to moderate hematopoiesis extramedullary spleen, minimal depletion of lymphoid spleen, minimal to mild thymic lymphoid depletion, and minimal to rats mild mandibular lymph nodes of lymphoid hyperplasia in men and women on Main Learn.

Those abnormal changes that Sepin-1 depending on the dose and largely reversible after a 28-day recovery period in animals of Recovery Study. Based on our results, we conclude that Sepin-1 at pharmacological dose (5-10 mg / kg) was well-tolerated, with no significant levels of mortality or morbidity, and can be developed as a potential new drug for treating Separase-expressed tumors.

Cohesin cleavage by separase enhanced with different substrate 

Chromosome segregation began when a cysteine ​​protease, separase, splitting Scc1 transition subunit of cohesin at the metaphase-to-anaphase. Separase inhibited before metaphase with securin tightly bound protein, which contains motifs separase pseudosubstrate blocking the active site.

To investigate the substrate specificity and regulation separase, here we developed a system to produce recombinant human separase securin free. Using these enzymes, we identified motif Scc1 LPE on a substrate different from the cleavage site and necessary for the rapid and specific cleavage of the substrate. LPE Securin also contain conserved motifs, and we provide evidence that this sequence motif involvement Scc1 separase block LPE. Our results indicate that rapid cohesin cleavage by separase require interaction substrate docking outside the active site. This interaction is blocked by securin, providing a second mechanism which inhibits securin cohesin cleavage.

eat-dose pharmacokinetic study Sepin-1 in mice. Sepin-1 intravenously to mice Sprague-Dawley once a day for 28 days in three different (5, 10 and 20mg / kg) dose. Blood samples were taken after dosing on days 1 and 28. Sepin-1 is not stable in phosphate-buffered saline at the base and stable pH buffer such as citric acid-buffered saline (pH 4.0). UHPLC-MS analysis showed Sepin-1 rapidly metabolized in vivo.

Alpha-Synuclein (1.0 mg) Human, Recombinant
AS-600-10	AlexoTech AB	1 mg	EUR 170.5

Alpha-Synuclein (10x 1mg) Human, Recombinant
AS-600-100	AlexoTech AB	10 X 1.0mg	EUR 1358.5

Alpha-Synuclein (50x 1mg) Human, Recombinant
As-600-500	AlexoTech AB	50 X 1.0mg	EUR 5967.5

Alpha-Synuclein 1-120 (1.0 mg) Human, Recombinant
AS-602-10	AlexoTech AB	1 mg	EUR 170.5

Alpha-Synuclein (A30P) (1.0 mg) Human, Recombinant
AS-603-10	AlexoTech AB	1 mg	EUR 247.5

Alpha-Synuclein (A53T) (1.0 mg) Human, Recombinant
AS-604-10	AlexoTech AB	1 mg	EUR 247.5

Alpha-Synuclein (E46K) (1.0 mg) Human, Recombinant
AS-605-10	AlexoTech AB	1 mg	EUR 247.5

Alpha-Synuclein (1.0 mg) Mouse, Recombinant
AS-650-10	AlexoTech AB	1 mg	EUR 170.5

Mouse IgG Anti-Transthyretin (39-44) (Amyloid Specific) 100 ug
AT-550-01	AlexoTech AB	100 ug	EUR 357.5

Mouse IgG Anti-Transthyretin (56-61) (Amyloid Specific) 100 ug
AT-560-01	AlexoTech AB	100 ug	EUR 357.5

Transthyretin (Wild Type) (10 X 1.0mg) Human, Recombinant
T-500-10	AlexoTech AB	1 mg	EUR 1628

Transthyretin (L12P) (1.0 mg) Human, Recombinant
T-501-10	AlexoTech AB	1 mg	EUR 330

Transthyretin (V30G) (1.0 mg) Human, Recombinant
T-502-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (A36P) (1.0 mg) Human, Recombinant
T-503-10	AlexoTech AB	1 mg	EUR 330

Transthyretin (D18G) (1.0 mg) Human, Recombinant
T-504-10	AlexoTech AB	1 mg	EUR 330

Transthyretin (V30M) (1.0 mg) Human, Recombinant
T-505-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (G53E) (1.0 mg) Human, Recombinant
T-506-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (V122I) (1.0 mg) Human, Recombinant
T-507-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (F87M/L110M) (1.0mg), Human, Recombinant
T-509-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (L55P) (1.0 mg) Human, Recombinant
T-510-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (F64S) (1.0mg), Human, Recombinant
T-511-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (Y69H) (1.0 mg) Human, Recombinant
T-512-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (T119M) (1.0 mg) Human, Recombinant
T-515-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (T60A) (1.0mg) Human, Recombinant
T-516-10	AlexoTech AB	1 mg	EUR 330

Transthyretin (A97S) (1.0mg) Human, Recombinant
T-517-10	AlexoTech AB	1 mg	EUR 330

Transthyretin (S52P) (1.0 mg) Human, Recombinant
T-518-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (L111M) (1.0 mg) Human, Recombinant
T-519-10	AlexoTech AB	1 mg	EUR 247.5

Transthyretin (V30I) (1.0 mg) Human, Recombinant
T-535-10	AlexoTech AB	1 mg	EUR 247.5

ELISA Flex: Bovine TNF-alpha (ALP)
3012-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine TNF-alpha (ALP)
3012-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Bovine TNF-alpha (HRP)
3012-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine TNF-alpha (HRP)
3012-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Bovine TNF-alpha (ALP)
3012-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Bovine TNF-alpha (HRP)
3012-2H	Mabtech AB	for 4 plates	EUR 609

Anti-bovine TNF-alpha mAb (MTF4918), unconjugated
3012-3-1000	Mabtech AB	1 mg	EUR 840

Anti-bovine TNF-alpha mAb (MTF4918), unconjugated
3012-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Bovine TNF-alpha (ALP)
3012-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Bovine TNF-alpha (ALP)
3012-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus Bovine TNF-alpha (HRP)
3012-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus Bovine TNF-alpha (HRP)
3012-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-bovine TNF-alpha mAb (MT771), biotin
3012-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-bovine TNF-alpha mAb (MT771), biotin
3012-6-250	Mabtech AB	250 µg	EUR 283.5

ELISA Flex: Porcine IL-17A (ALP)
3020-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Porcine IL-17A (ALP)
3020-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Porcine IL-17A (HRP)
3020-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Porcine IL-17A (HRP)
3020-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Porcine IL-17A (ALP)
3020-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Porcine IL-17A (HRP)
3020-2H	Mabtech AB	for 4 plates	EUR 609

ELISpot Plus: Porcine IL-17A (ALP)
3020-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Porcine IL-17A (ALP)
3020-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Porcine IL-17A (HRP)
3020-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Porcine IL-17A (HRP)
3020-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-porcine IL-17A mAb (MTP853), biotin
3020-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-porcine IL-17A mAb (MTP853), biotin
3020-6-250	Mabtech AB	250 µg	EUR 283.5

ELISpot Flex: Woodchuck IFN-gamma (ALP)
3101-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Woodchuck IFN-gamma (HRP)
3101-2H	Mabtech AB	for 4 plates	EUR 609

Anti-woodchuck IFN-gamma mAb (MT247), unconjugated
3101-3-1000	Mabtech AB	1 mg	EUR 840

Anti-woodchuck IFN-gamma mAb (MT247), unconjugated
3101-3-250	Mabtech AB	250 µg	EUR 241.5

Anti-woodchuck IFN-gamma mAb (MT225), biotin
3101-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-woodchuck IFN-gamma mAb (MT225), biotin
3101-6-250	Mabtech AB	250 µg	EUR 283.5

ELISA Flex: Hamster IFN-gamma (ALP)
3102-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Hamster IFN-gamma (ALP)
3102-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Hamster IFN-gamma (HRP)
3102-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Hamster IFN-gamma (HRP)
3102-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Hamster IFN-gamma (ALP)
3102-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Hamster IFN-gamma (HRP)
3102-2H	Mabtech AB	for 4 plates	EUR 609

Anti-hamster IFN-gamma mAb (MTH21), unconjugated
3102-3-1000	Mabtech AB	1 mg	EUR 840

Anti-hamster IFN-gamma mAb (MTH21), unconjugated
3102-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Hamster IFN-gamma (ALP)
3102-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Hamster IFN-gamma (ALP)
3102-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Hamster IFN-gamma (HRP)
3102-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Hamster IFN-gamma (HRP)
3102-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-hamster IFN-gamma mAb (MTH29), biotin
3102-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-hamster IFN-gamma mAb (MTH29), biotin
3102-6-250	Mabtech AB	250 µg	EUR 283.5

Anti-ferret IL-2 mAb (MT264), unconjugated
3104-1-1000	Mabtech AB	1 mg	EUR 840

Anti-ferret IL-2 mAb (MT264), unconjugated
3104-1-250	Mabtech AB	250 µg	EUR 241.5

ELISA Flex: Ferret IL-2 (ALP)
3104-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Ferret IL-2 (ALP)
3104-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Ferret IL-2 (HRP)
3104-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Ferret IL-2 (HRP)
3104-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Ferret IL-2 (ALP)
3104-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Ferret IL-2 (HRP)
3104-2H	Mabtech AB	for 4 plates	EUR 609

Anti-ferret IL-2 mAbs (MT264/271), unconjugated
3104-3-1000	Mabtech AB	1 mg	EUR 840

Anti-ferret IL-2 mAbs (MT264/271), unconjugated
3104-3-250	Mabtech AB	250 µg	EUR 241.5

ELISA Flex: Bovine IL-17A (ALP)
3109-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine IL-17A (ALP)
3109-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Bovine IL-17A (HRP)
3109-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine IL-17A (HRP)
3109-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Bovine IL-17A (ALP)
3109-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Bovine IL-17A (HRP)
3109-2H	Mabtech AB	for 4 plates	EUR 609

Anti-bovine IL-17A mAb (MT49A7), unconjugated
3109-3-1000	Mabtech AB	1 mg	EUR 840

Anti-bovine IL-17A mAb (MT49A7), unconjugated
3109-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Bovine IL-17A (ALP)
3109-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Bovine IL-17A (ALP)
3109-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Bovine IL-17A (HRP)
3109-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Bovine IL-17A (HRP)
3109-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-bovine IL-17A mAb (MT51B8), biotin
3109-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-bovine IL-17A mAb (MT51B8), biotin
3109-6-250	Mabtech AB	250 µg	EUR 283.5

ELISA Flex: Rabbit IFN-gamma (ALP)
3110-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Rabbit IFN-gamma (ALP)
3110-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Rabbit IFN-gamma (HRP)
3110-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Rabbit IFN-gamma (HRP)
3110-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Rabbit IFN-gamma (ALP)
3110-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Rabbit IFN-gamma (HRP)
3110-2H	Mabtech AB	for 4 plates	EUR 609

Anti-rabbit IFN-gamma mAb (MT327), unconjugated
3110-3-1000	Mabtech AB	1 mg	EUR 840

Anti-rabbit IFN-gamma mAb (MT327), unconjugated
3110-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Rabbit IFN-gamma (ALP)
3110-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Rabbit IFN-gamma (ALP)
3110-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Rabbit IFN-gamma (HRP)
3110-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Rabbit IFN-gamma (HRP)
3110-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-rabbit IFN-gamma mAb (MT318), biotin
3110-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-rabbit IFN-gamma mAb (MT318), biotin
3110-6-250	Mabtech AB	250 µg	EUR 283.5

Anti-rabbit IFN-gamma mAb (MT318), PF488P
3110-71-100T	Mabtech AB	100 tests	EUR 304.5

Anti-rabbit IFN-gamma mAb (MT318), PF647P
3110-72-100T	Mabtech AB	100 tests	EUR 304.5

ELISA Flex: Bovine IL-2 (ALP)
3111-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine IL-2 (ALP)
3111-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Bovine IL-2 (HRP)
3111-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine IL-2 (HRP)
3111-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Bovine IL-2 (ALP)
3111-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Bovine IL-2 (HRP)
3111-2H	Mabtech AB	for 4 plates	EUR 609

Anti-bovine IL-2 mAb (MT11A31), unconjugated
3111-3-1000	Mabtech AB	1 mg	EUR 840

Anti-bovine IL-2 mAb (MT11A31), unconjugated
3111-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Bovine IL-2 (ALP)
3111-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Bovine IL-2 (ALP)
3111-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Bovine IL-2 (HRP)
3111-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Bovine IL-2 (HRP)
3111-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-bovine IL-2 mAb (MT3B3), unconjugated
3111-5-250	Mabtech AB	250 µg	EUR 241.5

Anti-bovine IL-2 mAb (MT3B3), biotin
3111-6-250	Mabtech AB	250 µg	EUR 283.5

Anti-bovine IL-2 mAb (MT3B3), PF488P
3111-71-100T	Mabtech AB	100 tests	EUR 304.5

Anti-bovine IL-2 mAb (MT3B3), PF647P
3111-72-100T	Mabtech AB	100 tests	EUR 304.5

ELISA Flex: Ferret IFN-gamma (ALP)
3112-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Ferret IFN-gamma (ALP)
3112-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Ferret IFN-gamma (HRP)
3112-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Ferret IFN-gamma (HRP)
3112-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Ferret IFN-gamma (ALP)
3112-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Ferret IFN-gamma (HRP)
3112-2H	Mabtech AB	for 4 plates	EUR 609

Anti-ferret IFN-gamma mAb (MTF14), unconjugated
3112-3-1000	Mabtech AB	1 mg	EUR 840

Anti-ferret IFN-gamma mAb (MTF14), unconjugated
3112-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Ferret IFN-gamma (ALP)
3112-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Ferret IFN-gamma (ALP)
3112-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Ferret IFN-gamma (HRP)
3112-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Ferret IFN-gamma (HRP)
3112-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-ferret IFN-gamma mAb (MTF19), biotin
3112-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-ferret IFN-gamma mAb (MTF19), biotin
3112-6-250	Mabtech AB	250 µg	EUR 283.5

Anti-ferret IFN-gamma mAb (MTF14), PF488P
3112-71-100T	Mabtech AB	100 tests	EUR 304.5

Anti-ferret IFN-gamma mAb (MTF14), PF647P
3112-72-100T	Mabtech AB	100 tests	EUR 304.5

ELISA Flex: Canine IFN-gamma (ALP)
3113-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Canine IFN-gamma (ALP)
3113-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Canine IFN-gamma (HRP)
3113-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Canine IFN-gamma (HRP)
3113-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Canine IFN-gamma (ALP)
3113-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Canine IFN-gamma (HRP)
3113-2H	Mabtech AB	for 4 plates	EUR 609

Anti-canine IFN-gamma mAb (MT13), unconjugated
3113-3-1000	Mabtech AB	1 mg	EUR 840

Anti-canine IFN-gamma mAb (MT13), unconjugated
3113-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Canine IFN-gamma (ALP)
3113-4APW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Canine IFN-gamma (ALP)
3113-4APW-2	Mabtech AB	2 plates	EUR 535.5

ELISpot Plus: Canine IFN-gamma (HRP)
3113-4HPW-10	Mabtech AB	10 plates	EUR 2420.25

ELISpot Plus: Canine IFN-gamma (HRP)
3113-4HPW-2	Mabtech AB	2 plates	EUR 535.5

Anti-canine IFN-gamma mAb (MT166), biotin
3113-6-1000	Mabtech AB	1 mg	EUR 1044.75

Anti-canine IFN-gamma mAb (MT166), biotin
3113-6-250	Mabtech AB	250 µg	EUR 283.5

Anti-bovine IL-8 (CXCL8) mAbs (MT8H6/8F19), unconjugated
3114-1-1000	Mabtech AB	1 mg	EUR 840

Anti-bovine IL-8 (CXCL8) mAbs (MT8H6/8F19), unconjugated
3114-1-250	Mabtech AB	250 µg	EUR 241.5

ELISA Flex: Bovine IL-8 (ALP)
3114-1A-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine IL-8 (ALP)
3114-1A-6	Mabtech AB	for 6 plates	EUR 351.75

ELISA Flex: Bovine IL-8 (HRP)
3114-1H-20	Mabtech AB	for 20 plates	EUR 651

ELISA Flex: Bovine IL-8 (HRP)
3114-1H-6	Mabtech AB	for 6 plates	EUR 351.75

ELISpot Flex: Bovine IL-8 (ALP)
3114-2A	Mabtech AB	for 4 plates	EUR 609

ELISpot Flex: Bovine IL-8 (HRP)
3114-2H	Mabtech AB	for 4 plates	EUR 609

Anti-bovine IL-8 (CXCL8) mAb (MT8H6), unconjugated
3114-3-1000	Mabtech AB	1 mg	EUR 840

Anti-bovine IL-8 (CXCL8) mAb (MT8H6), unconjugated
3114-3-250	Mabtech AB	250 µg	EUR 241.5

ELISpot Plus: Bovine IL-8 (ALP)
3114-4APW-10	Mabtech AB	10 plates	EUR 2420.25

One of the major metabolite is stirring the amine of 2,2-dimethyl-5-nitro-2H-benzimidazole (named Sepin-1.55). Sepin-concentration in the blood samples was 1.55 Sepin-1 depending on the dose and used for pharmacokinetic analysis Sepin-1. Tmax was about 5-15 minutes.