Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, here we have profiled toxicity Sepin-1 in mice Sprague-Dawley in setting good laboratory practice (GLP). The maximum tolerated dose (MTD) of Sepin-1 in mice is 40 mg / kg in a single dose study and 20 mg / kg dose study for 7 days in a row.

Toxicity study consists of two parts-Main Study and Restoration Study. Sepin-1 to 0 (control), 5 (low dose), 10 (median dose), and 20 (high dose) mg / kg given by bolus intravenous injection to mice once a day for 28 consecutive days. The animals were euthanized at the Main Study Day 29, whereas in the study animals were allowed to recover Recovery for 28 days after 28 days Sepin-1 dose before they were euthanized on Day 29 of the off-dose periods.

Although the effects of Sepin-1 in low and median doses were minimal, hematological analysis shows that high doses of Sepin-1 associated with a decrease in red blood cells and hemoglobin, and an increase in the number of reticulocytes and platelets and mean corpuscular volume. Clinical chemistry showed that Sepin-1 causes increases in total bilirubin and a decrease in creatine kinase. histopathological analysis showed Sepin-1 results in minimal bone marrow erythroid hyperplasia, minimal to moderate hematopoiesis extramedullary spleen, minimal depletion of lymphoid spleen, minimal to mild thymic lymphoid depletion, and minimal to rats mild mandibular lymph nodes of lymphoid hyperplasia in men and women on Main Learn.

Those abnormal changes that Sepin-1 depending on the dose and largely reversible after a 28-day recovery period in animals of Recovery Study. Based on our results, we conclude that Sepin-1 at pharmacological dose (5-10 mg / kg) was well-tolerated, with no significant levels of mortality or morbidity, and can be developed as a potential new drug for treating Separase-expressed tumors.

Cohesin cleavage by separase enhanced with different substrate 

Chromosome segregation began when a cysteine ​​protease, separase, splitting Scc1 transition subunit of cohesin at the metaphase-to-anaphase. Separase inhibited before metaphase with securin tightly bound protein, which contains motifs separase pseudosubstrate blocking the active site.

To investigate the substrate specificity and regulation separase, here we developed a system to produce recombinant human separase securin free. Using these enzymes, we identified motif Scc1 LPE on a substrate different from the cleavage site and necessary for the rapid and specific cleavage of the substrate. LPE Securin also contain conserved motifs, and we provide evidence that this sequence motif involvement Scc1 separase block LPE. Our results indicate that rapid cohesin cleavage by separase require interaction substrate docking outside the active site. This interaction is blocked by securin, providing a second mechanism which inhibits securin cohesin cleavage.

eat-dose pharmacokinetic study Sepin-1 in mice. Sepin-1 intravenously to mice Sprague-Dawley once a day for 28 days in three different (5, 10 and 20mg / kg) dose. Blood samples were taken after dosing on days 1 and 28. Sepin-1 is not stable in phosphate-buffered saline at the base and stable pH buffer such as citric acid-buffered saline (pH 4.0). UHPLC-MS analysis showed Sepin-1 rapidly metabolized in vivo.

Goat anti-Human IgG F(ab')2 Affinity purified, Unconjugated
AS21-4574	Agrisera AB	2 mg	EUR 206

CsoS1A/B/C | Major carboxysome shell protein 1A, AB, 1C
AS14-2760	Agrisera AB	50 µg	EUR 302

Goat anti-Human IgG Fc, F(ab)'2 fragment, FITC conjugated
AS10-1236	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgG Fc, Biotin conjugated, F(ab)'2 fragment
AS10-806	Agrisera AB	0,5 mg	EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Unconjugated
AS10-846	Agrisera AB	1 mg	EUR 206

Goat anti-Human IgG Fc, F(ab)'2 Fragment, DyLight® 488 conjugated, min, cross-reactivity to human IgA, IgM or IgG F(ab)'2 fragment
AS16-3353	Agrisera AB	0,5 mg	EUR 196

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, HRP conjugated
AS10-1009	Agrisera AB	0,5 mg	EUR 246

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, FITC conjugated
AS10-1011	Agrisera AB	0,5 mg	EUR 185

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, TRITC conjugated
AS10-1018	Agrisera AB	0,5 mg	EUR 185

Goat anti-Human IgG + IgA + IgM, F(ab)'2 fragment, HRP conjugated
AS10-1039	Agrisera AB	0,5 mg	EUR 246

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-1045	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgA (alpha chain), F(ab)'2 fragment, FITC conjugated
AS10-1076	Agrisera AB	0,5 mg	EUR 239

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-1081	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgA (alpha chain), F(ab)'2 fragment, TRITC conjugated
AS10-1097	Agrisera AB	0,5 mg	EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated
AS10-1139	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Biotin conjugated
AS10-1200	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, ALP conjugated
AS10-1222	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, ALP conjugated
AS10-1237	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, Biotin conjugated
AS10-1253	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, FITC conjugated
AS10-1275	Agrisera AB	0,5 mg	EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated
AS10-1289	Agrisera AB	0,5 mg	EUR 175

Goat anti-Human IgG (H&L), F(ab)'2 fragment, FITC conjugated
AS10-1295	Agrisera AB	0,5 mg	EUR 185

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, TRITC conjugated
AS10-1306	Agrisera AB	0,5 mg	EUR 233

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, FITC conjugated
AS16-3450	Agrisera AB	0,5 mg	EUR 206

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, HRP conjugated
AS16-3454	Agrisera AB	0,5 mg	EUR 233

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, TRITC conjugated
AS16-3467	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, Unconjugated
AS10-743	Agrisera AB	1 mg	EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, ALP conjugated
AS10-774	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-775	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-779	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgG Fc, F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-805	Agrisera AB	1 mg	EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, ALP conjugated
AS10-848	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-849	Agrisera AB	0,5 mg	EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-852	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, TRITC conjugated
AS10-946	Agrisera AB	0,5 mg	EUR 185

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated
AS10-967	Agrisera AB	0,5 mg	EUR 175

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, FITC conjugated
AS10-991	Agrisera AB	0,5 mg	EUR 246

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Biotin conjugated
AS10-997	Agrisera AB	0,5 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated
AS10-998	Agrisera AB	0,5 mg	EUR 185

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-1029	Agrisera AB	1 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-1163	Agrisera AB	1 mg	EUR 175

Goat anti-Human IgA + IgG + IgM, F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-1184	Agrisera AB	1 mg	EUR 175

TSH (beta) | thyroid stimulating hormone (Affinity purified, F(ab)2' fragment, goat antibody)
AS10-1325	Agrisera AB	0,5 mg	EUR 532

Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, Biotin conjugated
AS10-745	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgA heavy (alpha chain), F(ab)'2 fragment, HRP conjugated
AS10-746	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-773	Agrisera AB	1 mg	EUR 206

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated
AS10-960	Agrisera AB	1 mg	EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 488 conjugated
AS10-1220	Agrisera AB	0,5 mg	EUR 206

Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment, DyLight® 488 conjugated
AS16-3526	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 Fragment, DyLight® 488 conjugated
AS16-3527	Agrisera AB	0,5 mg	EUR 202

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated
AS12-2182	Agrisera AB	0,5 mg	EUR 206

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated
AS12-2189	Agrisera AB	0,5 mg	EUR 206

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated
AS12-2381	Agrisera AB	0,5 mg	EUR 233

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated
AS12-2428	Agrisera AB	0,5 mg	EUR 246

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, HRP conjugated, min,reactivity to human, mouse IgG
AS10-1145	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgG Fc, F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-814	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgG Fc, F(ab)'2 fragment, HRP conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-817	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgG Fc, F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1001	Agrisera AB	0,5 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human IgG/serum
AS10-1002	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human, mouse IgG
AS10-1023	Agrisera AB	0,5 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human IgG/serum
As10-1071	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human, mouse IgG
AS10-1088	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgG Fc, F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1099	Agrisera AB	0,5 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human IgG/serum
AS10-1189	Agrisera AB	0,5 mg	EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to human IgG/serum
AS10-1193	Agrisera AB	0,5 mg	EUR 246

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human, mouse IgG
AS10-1234	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgM (µ chain), F(ab)'2 Fragment, min, cross-reactivity to IgG from human or mouse
AS16-3371	Agrisera AB	1,0 mg	EUR 238

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-782	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity bovine/mouse/rabbit serum
AS10-785	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgG Fc, F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-813	Agrisera AB	0,5 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human IgG/serum
AS10-981	Agrisera AB	0,5 mg	EUR 233

SEPARASE (Ab-801) Antibody
8B0086	AAT Bioquest	50ug	EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Ab-801) Antibody
E11-0086B	EnoGene	100μg	EUR 225
Description: Available in various conjugation types.

SEPARASE (Ab-801) Antibody
MBS859119-01mg	MyBiosource	0.1mg	EUR 305

SEPARASE (Ab-801) Antibody
MBS859119-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

SEPARASE (Ab-801) Antibody
MBS859119-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

SEPARASE (Ab-801) Antibody
MBS859119-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

SEPARASE (Ab-801) Antibody
MBS859119-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

Goat anti-Human IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1015	Agrisera AB	0,5 mg	EUR 233

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human, mouse,Rat IgG
AS10-1058	Agrisera AB	0,5 mg	EUR 246

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human, mouse,Rat IgG
AS10-1065	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to human IgG or IgA
AS10-1090	Agrisera AB	0,5 mg	EUR 233

Goat anti-Human IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,mouse,rabbit serum
AS10-1157	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human, mouse IgG
AS10-1215	Agrisera AB	1 mg	EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to human IgG or IgA
AS10-1287	Agrisera AB	0,5 mg	EUR 259

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human IgA+IgG
AS10-1296	Agrisera AB	1 mg	EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to human IgG or IgA
AS10-1298	Agrisera AB	0,5 mg	EUR 273

Goat anti-Human IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-781	Agrisera AB	0,5 mg	EUR 206

Goat anti-Human IgG Fc, F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-812	Agrisera AB	1 mg	EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to human IgG or IgA
AS10-959	Agrisera AB	0,5 mg	EUR 246

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human IgG/serum
AS10-961	Agrisera AB	1 mg	EUR 233

Goat anti-Human IgM (µ chain), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to human IgG or IgA
AS10-979	Agrisera AB	0,5 mg	EUR 273

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovin, human, mouse IgG/serum
AS10-1042	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1059	Agrisera AB	0,5 mg	EUR 233

Rabbit anti-Goat IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to human, mouse,Rat IgG
AS10-1077	Agrisera AB	1 mg	EUR 246

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1146	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1153	Agrisera AB	0,5 mg	EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, DyLight® 488 conjugated, min, cross-reactivity to human, mouse lgG
AS10-1217	Agrisera AB	0,5 mg	EUR 259

Goat anti-Human IgG Fc, F(ab)'2 Fragment, min, cross-reactivity to Human IgA/IgM, Bovine, Horse, Mouse, Rabbit Serum
AS16-3350	Agrisera AB	0,5 mg	EUR 216

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3459	Agrisera AB	1,0 mg	EUR 284

Goat anti-Human IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine/mouse/rabbit serum
AS10-780	Agrisera AB	1 mg	EUR 233

Goat anti-Rat IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated, min, cross-reactivity to human, mouse lgG
AS12-1980	Agrisera AB	0,5 mg	EUR 246

Goat anti-Human IgG Fc, F(ab)'2 Fragment, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3356	Agrisera AB	1,0 mg	EUR 238

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3461	Agrisera AB	1,0 mg	EUR 252

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, Affinity purified, Unconjugated, min, cross-reactivity to bovine, human, mouse IgG/serum
AS10-982	Agrisera AB	1 mg	EUR 190

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, ALP (alkaline phosphatase) conjugated, min, cross-reactivity to bovine,human, mouse IgG/serum
AS10-1017	Agrisera AB	0,5 mg	EUR 233

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3441	Agrisera AB	0,5 mg	EUR 264

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3445	Agrisera AB	0,5 mg	EUR 300

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3452	Agrisera AB	0,5 mg	EUR 284

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3456	Agrisera AB	0,5 mg	EUR 300

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG
AS16-3468	Agrisera AB	0,5 mg	EUR 284

Goat anti-Rabbit IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to non-immunoglobulin rabbit serum proteins and human serum proteins
AS16-3530	Agrisera AB	1,0 mg	EUR 203

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 800 conjugated, min, cross-reactivity to human IgG or serum proteins
AS12-2436	Agrisera AB	0,5 mg	EUR 220

Goat anti-Human IgG Fc, F(ab)'2 Fragment, FITC conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3354	Agrisera AB	0,5 mg	EUR 238

Goat anti-Human IgG Fc, F(ab)'2 Fragment, HRP conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3355	Agrisera AB	0,5 mg	EUR 245

Goat anti-Human IgG Fc, F(ab)'2 Fragment, TRITC conjugated, min, cross-reactivity to bovine, horse, mouse or rabbit serum proteins, mouse IgG1
AS16-3358	Agrisera AB	0,5 mg	EUR 275

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugated min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3440	Agrisera AB	0,5 mg	EUR 257

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin-conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3462	Agrisera AB	0,5 mg	EUR 238

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3463	Agrisera AB	0,5 mg	EUR 214

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3464	Agrisera AB	0,5 mg	EUR 183

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, horse, human, pig or rabbit serum protein
AS16-3465	Agrisera AB	0,5 mg	EUR 214

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3460	Agrisera AB	1,0 mg	EUR 406

Donkey anti-Rabbit IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to Bovine, Chicken, Goat, Guinea Pig, Hamster, Horse, Human, Mouse, Rat or Sheep
AS16-3522	Agrisera AB	0,5 mg	EUR 213

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated,min, cross-reactivity to bovine, horse, human, pig or rabbit serum proteins
AS12-1945	Agrisera AB	0,5 mg	EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, DyLight® 550 conjugated,min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins
AS12-1968	Agrisera AB	0,5 mg	EUR 206

Goat anti-Rabbit IgG (H&L), F(ab)'2 fragment, DyLight® 594 conjugated, min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins
AS12-2083	Agrisera AB	0,5 mg	EUR 206

Goat anti-Rabbit IgG (H&L) -F(ab)'2 fragment, DyLight® 650 conjugated, min, cross-reactivity to bovine, human, or Mouse lgG or serum proteins
AS12-2337	Agrisera AB	0,5 mg	EUR 220

Donkey anti-Mouse IgG (H&L), F(ab)'2 Fragment, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3458	Agrisera AB	0,5 mg	EUR 213

Goat anti-Mouse IgG (H&L), F(ab)'2 Fragment, ALP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3442	Agrisera AB	0,5 mg	EUR 381

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3446	Agrisera AB	0,5 mg	EUR 442

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3457	Agrisera AB	0,5 mg	EUR 442

Goat anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugated, min, cross-reactivity to bovine, goat, human, rabbit, or rat IgG (highly absorbed against rat IgG)
AS16-3469	Agrisera AB	0,5 mg	EUR 406

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, ALP conjugate, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3439	Agrisera AB	0,5 mg	EUR 360

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, Biotin conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3444	Agrisera AB	0,5 mg	EUR 300

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, FITC conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3451	Agrisera AB	0,5 mg	EUR 287

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, HRP conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3455	Agrisera AB	0,5 mg	EUR 300

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, TRITC conjugate, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS16-3466	Agrisera AB	0,5 mg	EUR 287

Donkey anti-Mouse IgG (H&L), F(ab)'2 fragment, DyLight® 633 conjugated, min, cross-reactivity to bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
AS12-2183	Agrisera AB	0,5 mg	EUR 334

Anti-CXCR4 (NT) Antibody
1009	Genovis AB	100ug	EUR 445

Anti-Factor VIII Antibody
10101	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10101-100	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10101-1000	Genovis AB	1mg	EUR 903

Anti-Factor VIII Antibody
10101-500	Genovis AB	500ug	EUR 460

Anti-Factor VIII Antibody
10102	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10102-100	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10102-1000	Genovis AB	1mg	EUR 903

Anti-Factor VIII Antibody
10102-500	Genovis AB	500ug	EUR 460

Anti-Factor VIII Antibody
10103	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10103-100	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10103-1000	Genovis AB	1mg	EUR 903

Anti-Factor VIII Antibody
10103-500	Genovis AB	500ug	EUR 460

Anti-Factor VIII Antibody
10104	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10104-100	Genovis AB	100ug	EUR 230

Anti-Factor VIII Antibody
10104-1000	Genovis AB	1mg	EUR 903

Anti-Factor VIII Antibody
10104-500	Genovis AB	500ug	EUR 460

Anti-Mouse Sperm Protein sp56 Antibody
55101	Genovis AB	100ug	EUR 390

Anti-Mouse Sperm Protein sp56 Antibody
55102	Genovis AB	100ug	EUR 382

Anti-Mouse Sperm Protein sp56 Antibody
55103	Genovis AB	100ug	EUR 382

Anti-Mouse Sperm Protein sp56 Antibody
55104	Genovis AB	100ug	EUR 382

Mikrogen Diagnostik recomLine Cytomegalovirus IgG (Avidity) Lateral Strip Test Kit
5572	Genovis AB	20 Tests	EUR 660

Mikrogen Diagnostik recomLine Cytomegalovirus IgM Lateral Strip Test Kit
5573	Genovis AB	20 Tests	EUR 660

Mikrogen Diagnostik recomWell HEV IgG ELISA Kit
5004	Genovis AB	96 Tests	EUR 632

Mikrogen Diagnostik recomWell HEV IgM ELISA Kit
5005	Genovis AB	96 Tests	EUR 632

Anti-Insulin receptor (α subunit) Antibody
50101	Genovis AB	100ug	EUR 452

Anti-Insulin receptor Antibody
50102	Genovis AB	100ug	EUR 452

Anti-Insulin receptor (α subunit) Antibody
50103	Genovis AB	100ug	EUR 452

Anti-Insulin receptor (beta subunit) Antibody
50104	Genovis AB	100ug	EUR 461

Anti-Osteocalcin Antibody
50114	Genovis AB	100ug	EUR 509

Anti-Osteocalcin Antibody
50116	Genovis AB	100ug	EUR 509

Anti-Osteocalcin Antibody
50118	Genovis AB	100ug	EUR 509

Anti-Osteocalcin Antibody
50120	Genovis AB	100ug	EUR 509

One of the major metabolite is stirring the amine of 2,2-dimethyl-5-nitro-2H-benzimidazole (named Sepin-1.55). Sepin-concentration in the blood samples was 1.55 Sepin-1 depending on the dose and used for pharmacokinetic analysis Sepin-1. Tmax was about 5-15 minutes.