Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, here we have profiled toxicity Sepin-1 in mice Sprague-Dawley in setting good laboratory practice (GLP). The maximum tolerated dose (MTD) of Sepin-1 in mice is 40 mg / kg in a single dose study and 20 mg / kg dose study for 7 days in a row.

Toxicity study consists of two parts-Main Study and Restoration Study. Sepin-1 to 0 (control), 5 (low dose), 10 (median dose), and 20 (high dose) mg / kg given by bolus intravenous injection to mice once a day for 28 consecutive days. The animals were euthanized at the Main Study Day 29, whereas in the study animals were allowed to recover Recovery for 28 days after 28 days Sepin-1 dose before they were euthanized on Day 29 of the off-dose periods.

Although the effects of Sepin-1 in low and median doses were minimal, hematological analysis shows that high doses of Sepin-1 associated with a decrease in red blood cells and hemoglobin, and an increase in the number of reticulocytes and platelets and mean corpuscular volume. Clinical chemistry showed that Sepin-1 causes increases in total bilirubin and a decrease in creatine kinase. histopathological analysis showed Sepin-1 results in minimal bone marrow erythroid hyperplasia, minimal to moderate hematopoiesis extramedullary spleen, minimal depletion of lymphoid spleen, minimal to mild thymic lymphoid depletion, and minimal to rats mild mandibular lymph nodes of lymphoid hyperplasia in men and women on Main Learn.

Those abnormal changes that Sepin-1 depending on the dose and largely reversible after a 28-day recovery period in animals of Recovery Study. Based on our results, we conclude that Sepin-1 at pharmacological dose (5-10 mg / kg) was well-tolerated, with no significant levels of mortality or morbidity, and can be developed as a potential new drug for treating Separase-expressed tumors.

Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Cohesin cleavage by separase enhanced with different substrate 

Chromosome segregation began when a cysteine ​​protease, separase, splitting Scc1 transition subunit of cohesin at the metaphase-to-anaphase. Separase inhibited before metaphase with securin tightly bound protein, which contains motifs separase pseudosubstrate blocking the active site.

To investigate the substrate specificity and regulation separase, here we developed a system to produce recombinant human separase securin free. Using these enzymes, we identified motif Scc1 LPE on a substrate different from the cleavage site and necessary for the rapid and specific cleavage of the substrate. LPE Securin also contain conserved motifs, and we provide evidence that this sequence motif involvement Scc1 separase block LPE. Our results indicate that rapid cohesin cleavage by separase require interaction substrate docking outside the active site. This interaction is blocked by securin, providing a second mechanism which inhibits securin cohesin cleavage.


eat-dose pharmacokinetic study Sepin-1 in mice. Sepin-1 intravenously to mice Sprague-Dawley once a day for 28 days in three different (5, 10 and 20mg / kg) dose. Blood samples were taken after dosing on days 1 and 28. Sepin-1 is not stable in phosphate-buffered saline at the base and stable pH buffer such as citric acid-buffered saline (pH 4.0). UHPLC-MS analysis showed Sepin-1 rapidly metabolized in vivo.

JTC-801

A8456-5.1 10 mM (in 1mL DMSO)
EUR 142.8
Description: JTC 801 is a high affinity, selective KOR-3 (NOP) receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human ?-, ?- and ?-opioid receptors respectively.

JTC-801

A8456-50 50 mg
EUR 393.6
Description: JTC 801 is a high affinity, selective KOR-3 (NOP) receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human ?-, ?- and ?-opioid receptors respectively.

JTC-801

HY-13274 50mg
EUR 472.8

(+)-MK 801 Maleate

A8896-10 10 mg
EUR 126
Description: (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties.

(+)-MK 801 Maleate

A8896-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties.

(+)-MK 801 Maleate

A8896-50 50 mg
EUR 319.2
Description: (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties.

(+)-MK 801 Hydrogen Maleate

B2326-25 each
EUR 418.8

(+)-MK 801 Hydrogen Maleate

B2326-5 each
EUR 157.2

(-)-MK 801 Hydrogen Maleate

B2327-25 each
EUR 418.8

(-)-MK 801 Hydrogen Maleate

B2327-5 each
EUR 157.2

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC800801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC800801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC810801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC810801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC940801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF594 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC940801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF594 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC700801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF770 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC700801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF770 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC880801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF488A conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC880801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF488A conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC050801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405M conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC050801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405M conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC040801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405S conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC040801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405S conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC400801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF640R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC400801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF640R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCB0801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Biotin conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCAP0801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCAP0801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCA0801-250 250uL
EUR 459.6
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), APC conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCB0801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Biotin conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCR0801-250 250uL
EUR 459.6
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), RPE conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCP0801-250 250uL
EUR 459.6
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), PerCP conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNUM0801-50 50uL
EUR 474
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), 1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCH0801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCH0801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNUB0801-100 100uL
EUR 250.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Concentration: 0.2mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNUB0801-500 500uL
EUR 549.6
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Concentration: 0.2mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC610801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF660R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC610801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF660R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC550801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF555 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC550801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF555 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC430801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF543 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC430801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF543 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC680801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF568 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC680801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF568 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC470801-100 100uL
EUR 238.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF647 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC470801-500 500uL
EUR 652.8
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF647 conjugate, Concentration: 0.1mg/mL

Anti-Human PSA Antibody | MPSA-80A-801

MPSA-80A-801 1.0 mg
EUR 334
Description:

Anti-Human PSA Antibody ; MPSA-80A-801 ; Immunology Consultants Laboratory

Host: Mouse

Format: Purified Monoclonal

Product Type: Primary Antibody

Antibody Clonality: Monoclonal

Prostate Specific Antigen (PSA); Clone KLK3/801 (Concentrate)

RA0009-C.1 0.1 ml
EUR 150

Prostate Specific Antigen (PSA); Clone KLK3/801 (Concentrate)

RA0009-C.5 0.5 ml
EUR 360

Recombinant Streptococcus Pyogenes ftsK Protein (aa 1-801)

VAng-Cr8109-inquire inquire Ask for price
Description: Streptococcus Pyogenes serotype M18 DNA translocase FtsK (ftsK), recombinant protein.

Recombinant Neisseria Gonorrhoeae lptD Protein (aa 1-801)

VAng-Wyb2182-inquire inquire Ask for price
Description: Neisseria Gonorrhoeae (strain ATCC 700825 / FA 1090) LPS-assembly protein lptD, recombinant protein.

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC941256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF594 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC941256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF594 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC801256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF680 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC801256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF680 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC811256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF680R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC811256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF680R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC701256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF770 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC701256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF770 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC881256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF488A conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC881256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF488A conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC051256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405M conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC051256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405M conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC041256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405S conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC041256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405S conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC401256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF640R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC401256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF640R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCB1256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Biotin conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCB1256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Biotin conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCAP1256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCAP1256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCA1256-250 250uL
EUR 459.6
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), APC conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCR1256-250 250uL
EUR 459.6
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), RPE conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCP1256-250 250uL
EUR 459.6
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), PerCP conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNUM1256-50 50uL
EUR 474
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), 1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCH1256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCH1256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNUB1256-100 100uL
EUR 250.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Concentration: 0.2mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNUB1256-500 500uL
EUR 549.6
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Concentration: 0.2mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC611256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF660R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC611256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF660R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC551256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF555 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC551256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF555 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC431256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF543 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC431256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF543 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC681256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF568 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC681256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF568 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC471256-100 100uL
EUR 238.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF647 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC471256-500 500uL
EUR 652.8
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF647 conjugate, Concentration: 0.1mg/mL

Activin AB

PR15011 5 ug
EUR 577.2

Soyasaponin Ab

HY-N3026 5mg
EUR 338.4

AB-423

HY-112142 100mg
EUR 2469.6

AB-MECA

HY-19365 5mg
EUR 456

AB-680

HY-125286 10mg
EUR 2126.4

Anti-Prostate Specific Antigen Antibody Clone KLK3/801, Unconjugated-100ug

354-MSM2-P1 100ug
EUR 513.6

Thyroid Ab/ Rat Thyroid Ab ELISA Kit

ELA-E0844r 96 Tests
EUR 1063.2

GNRHR-Ab/ Rat GNRHR- Ab ELISA Kit

ELA-E0962r 96 Tests
EUR 1063.2

MAG Ab/ Rat MAG Ab ELISA Kit

ELA-E0995r 96 Tests
EUR 1063.2

DNP-Ab/ Rat DNP- Ab ELISA Kit

ELA-E1122r 96 Tests
EUR 1063.2

ENA-Ab/ Rat ENA- Ab ELISA Kit

ELA-E1124r 96 Tests
EUR 1063.2

RNP-Ab/ Rat RNP- Ab ELISA Kit

ELA-E1129r 96 Tests
EUR 1063.2

PDGF-AB/ Rat PDGF- AB ELISA Kit

ELA-E0112r 96 Tests
EUR 1063.2

MBP-Ab/ Rat MBP- Ab ELISA Kit

ELA-E0170r 96 Tests
EUR 1063.2

MC Ab/ Rat MC Ab ELISA Kit

ELA-E0390r 96 Tests
EUR 1063.2

TPO-Ab/ Rat TPO- Ab ELISA Kit

ELA-E0442r 96 Tests
EUR 1063.2

Mouse ACV-AB(Activin AB) ELISA Kit

EM0312 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

PDGF AB protein

30R-2610 10 ug
EUR 430.8
Description: Purified recombinant Human PDGF AB protein

PDGF AB protein

30R-AP003 10 ug
EUR 327.6
Description: Purified recombinant Human PDGF AB protein

AB-Pinaca Antibody

abx023942-1mg 1 mg
EUR 744

AB-Pinaca Antibody

abx023943-1mg 1 mg
EUR 744

NGAL (Capture Ab)

20-abx019240
  • EUR 176.40
  • EUR 777.60
  • EUR 260.40
  • EUR 493.20
  • EUR 126.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50 ug

NGAL (Capture Ab)

20-abx019241
  • EUR 176.40
  • EUR 777.60
  • EUR 493.20
  • 100 ug
  • 1 mg
  • 500 ug

NGAL (Detection Ab)

abx019242-100ug 100 ug
EUR 777.6

Apoa5 (ab) Antibody

BF0615 200ul
EUR 540

rHu PDGF-AB

AK8282-0002 2µg Ask for price

rHu PDGF-AB

AK8282-0010 10µg Ask for price

rHu PDGF-AB

AK8282-0100 100µg Ask for price

rHu PDGF-AB

AK8282-1000 1mg Ask for price

Elk-1 Ab

3387-100 each
EUR 405.6

AB-2950 MPEC

351201 5unit
EUR 334.8
Description: Super oxide(O2) reaction system L ight Emittingreagent

AB-2960 BactoLumix

3512020 2unit
EUR 378
Description: Menadione oxidation-reduction reaction system for probiotic measurement

AB-3000B Cellgraph

3600000 unit
EUR 120

Ab buffer kit

28903059 EACH
EUR 184.8

Apoa5 (ab) Antibody

abx010415-100ul 100 ul
EUR 493.2

Activin AB, CF

PR15011CF 5 ug
EUR 577.2

PDGF - AB Human

PR27062 2 ug
EUR 229.2

Ab Rabbit GluR2*

P40014-100uL 100uL Ask for price

Ab Rabbit MARCKS*

P40017-100uL 100uL Ask for price

Ab MS GluR1*

P80000-100uL 100uL Ask for price

Human Serum AB

SC00B14 100 ml
EUR 434.4

AB-2950 MPEC

3512010 each
EUR 6600

ELISA kit for Mouse ACV-AB (Activin AB)  Kit

E-EL-M2660 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse ACV-AB (Activin AB)  Kit in samples from Serum, Plasma, Cell supernatant

n-DNA-Ab/ Rat n- DNA- Ab ELISA Kit

ELA-E1126r 96 Tests
EUR 1063.2

Sc1-70-Ab/ Rat Sc1- 70- Ab ELISA Kit

ELA-E1131r 96 Tests
EUR 1063.2

IFN-Gamma ab/ Rat IFN- Gamma ab ELISA Kit

ELA-E1716r 96 Tests
EUR 1063.2

G-CSF ab/ Rat G- CSF ab ELISA Kit

ELA-E1717r 96 Tests
EUR 1063.2

ACV-AB ELISA Kit| Mouse Activin AB ELISA Kit

EF012990 96 Tests
EUR 826.8

Anti-Prostate Specific Antigen Antibody Clone KLK3/801 + KLK3/1248, Unconjugated-100ug

354-MSM6-P1 100ug
EUR 513.6

Human Platelet Derived Growth Factor AB (PDGF-AB) CLIA Kit

abx197488-96tests 96 tests
EUR 990

Rat Platelet-Derived Growth Factor AB (PDGF-AB) CLIA Kit

abx197512-96tests 96 tests
EUR 990

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

201-12-0138 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Pig Platelet-Derived Growth Factor AB (PDGF-AB) ELISA kit

CSB-EQ027978PI-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Pig Platelet-Derived Growth Factor AB (PDGF-AB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig Platelet-Derived Growth Factor AB (PDGF-AB) ELISA kit

1-CSB-EQ027978PI
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Pig Platelet-Derived Growth Factor AB (PDGF-AB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-03255H1 96T
EUR 560.4

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-03255H2 48T
EUR 379.2

Rat Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-01590R1 96T
EUR 548.4

Rat Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-01590R2 48T
EUR 367.2

Mouse Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-02423M1 96T
EUR 548.4

Mouse Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

CN-02423M2 48T
EUR 367.2

Human Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

CSB-E04701h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

1-CSB-E04701h
  • EUR 867.60
  • EUR 5859.60
  • EUR 3109.20
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

CSB-E04703r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Platelet-Derived Growth Factor AB, PDGF-AB ELISA kit

1-CSB-E04703r
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Platelet-Derived Growth Factor AB, PDGF-AB in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

CSB-E15910Rb-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rabbit Platelet-Derived Growth Factor AB (PDGF-AB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

1-CSB-E15910Rb
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rabbit Platelet-Derived Growth Factor AB(PDGF-AB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat PDGF-AB(Platelet-Derived Growth Factor AB) ELISA Kit

ER0056 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 4.688pg/ml

Rabbit PDGF-AB(Platelet Derived Growth Factor AB) ELISA Kit

ERB0095 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 0.938 ng/ml

Rat Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0700RT-48T 48T
EUR 447.6

Rat Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0700RT-96T 96T
EUR 730.8

Human Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0076HM-48T 48T
EUR 346.8

Human Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0076HM-96T 96T
EUR 559.2

Mouse Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0148MS-48T 48T
EUR 403.2

Mouse Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

GA-E0148MS-96T 96T
EUR 640.8

Human PDGF-AB(Platelet-Derived Growth Factor AB) ELISA Kit

EH0139 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Rat Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

QY-E10952 96T
EUR 433.2

Mouse Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

QY-E21208 96T
EUR 433.2

Human Platelet-Derived Growth Factor AB(PDGF-AB)ELISA Kit

QY-E00586 96T
EUR 480

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

YLA2092HU-48T 48T
EUR 435

Human Platelet-Derived Growth Factor AB,PDGF-AB ELISA kit

YLA2092HU-96T 96T
EUR 562.5

One of the major metabolite is stirring the amine of 2,2-dimethyl-5-nitro-2H-benzimidazole (named Sepin-1.55). Sepin-concentration in the blood samples was 1.55 Sepin-1 depending on the dose and used for pharmacokinetic analysis Sepin-1. Tmax was about 5-15 minutes.

Karina

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