Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.

Sepin-1 is a small compound that inhibits the enzymatic activity of Separase and growth of cancer cells. As part of the IND-enabling studies to develop Sepin-1 as a chemotherapeutic agent, here we have profiled toxicity Sepin-1 in mice Sprague-Dawley in setting good laboratory practice (GLP). The maximum tolerated dose (MTD) of Sepin-1 in mice is 40 mg / kg in a single dose study and 20 mg / kg dose study for 7 days in a row.

Toxicity study consists of two parts-Main Study and Restoration Study. Sepin-1 to 0 (control), 5 (low dose), 10 (median dose), and 20 (high dose) mg / kg given by bolus intravenous injection to mice once a day for 28 consecutive days. The animals were euthanized at the Main Study Day 29, whereas in the study animals were allowed to recover Recovery for 28 days after 28 days Sepin-1 dose before they were euthanized on Day 29 of the off-dose periods.

Although the effects of Sepin-1 in low and median doses were minimal, hematological analysis shows that high doses of Sepin-1 associated with a decrease in red blood cells and hemoglobin, and an increase in the number of reticulocytes and platelets and mean corpuscular volume. Clinical chemistry showed that Sepin-1 causes increases in total bilirubin and a decrease in creatine kinase. histopathological analysis showed Sepin-1 results in minimal bone marrow erythroid hyperplasia, minimal to moderate hematopoiesis extramedullary spleen, minimal depletion of lymphoid spleen, minimal to mild thymic lymphoid depletion, and minimal to rats mild mandibular lymph nodes of lymphoid hyperplasia in men and women on Main Learn.

Those abnormal changes that Sepin-1 depending on the dose and largely reversible after a 28-day recovery period in animals of Recovery Study. Based on our results, we conclude that Sepin-1 at pharmacological dose (5-10 mg / kg) was well-tolerated, with no significant levels of mortality or morbidity, and can be developed as a potential new drug for treating Separase-expressed tumors.

Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.

Cohesin cleavage by separase enhanced with different substrate 

Chromosome segregation began when a cysteine ​​protease, separase, splitting Scc1 transition subunit of cohesin at the metaphase-to-anaphase. Separase inhibited before metaphase with securin tightly bound protein, which contains motifs separase pseudosubstrate blocking the active site.

To investigate the substrate specificity and regulation separase, here we developed a system to produce recombinant human separase securin free. Using these enzymes, we identified motif Scc1 LPE on a substrate different from the cleavage site and necessary for the rapid and specific cleavage of the substrate. LPE Securin also contain conserved motifs, and we provide evidence that this sequence motif involvement Scc1 separase block LPE. Our results indicate that rapid cohesin cleavage by separase require interaction substrate docking outside the active site. This interaction is blocked by securin, providing a second mechanism which inhibits securin cohesin cleavage.


eat-dose pharmacokinetic study Sepin-1 in mice. Sepin-1 intravenously to mice Sprague-Dawley once a day for 28 days in three different (5, 10 and 20mg / kg) dose. Blood samples were taken after dosing on days 1 and 28. Sepin-1 is not stable in phosphate-buffered saline at the base and stable pH buffer such as citric acid-buffered saline (pH 4.0). UHPLC-MS analysis showed Sepin-1 rapidly metabolized in vivo.

JTC-801

A8456-5 5 mg
EUR 108
Description: JTC 801 is a high affinity, selective KOR-3 (NOP) receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human ?-, ?- and ?-opioid receptors respectively.

JTC-801

A8456-5.1 10 mM (in 1mL DMSO)
EUR 119
Description: JTC 801 is a high affinity, selective KOR-3 (NOP) receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human ?-, ?- and ?-opioid receptors respectively.

JTC-801

A8456-50 50 mg
EUR 328
Description: JTC 801 is a high affinity, selective KOR-3 (NOP) receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human ?-, ?- and ?-opioid receptors respectively.

Goat polyclonal antibody for Cytomegalovirus

801 1 ml
EUR 272.94
Description: This is goat polyclonal antibody against Cytomegalovirus AD 169 for WB, ELISA.

(+)-MK 801 Maleate

A8896-10 10 mg
EUR 105
Description: (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties.

(+)-MK 801 Maleate

A8896-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties.

(+)-MK 801 Maleate

A8896-50 50 mg
EUR 266
Description: (+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM [1].MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties.

(+)-MK 801 Hydrogen Maleate

B2326-25
EUR 349

(+)-MK 801 Hydrogen Maleate

B2326-5
EUR 131

(-)-MK 801 Hydrogen Maleate

B2327-25
EUR 349

(-)-MK 801 Hydrogen Maleate

B2327-5
EUR 131

pSMPUW-GFP-LC3 Lentiviral Expression Vector

LTV-801 10 µg
EUR 1204
Description: Expression vector contains a fusion of GFP and LC3. A separate GFP control vector is also included.

OxiSelect In Vitro Nitric Oxide (Nitrite / Nitrate) Assay Kit (Fluorometric)

STA-801 100 assays
EUR 473
Description: Cell Biolabs? OxiSelect Nitric Oxide (Nitrite/Nitrate) Assay Kit is a simple, colorimetric assay that quantitatively measures NO in various samples by NO2-/NO3- determination.  First, the nitrate (NO3-) in the sample is converted to nitrite (NO2-) by nitrate reductase enzyme.  Next, total nitrite is detected with Griess Reagents as a colored azo dye product (absorbance 540 nm).  Each kit provides sufficient reagents to perform up to 100 assays using a 96-well microtiter plate format, including blanks, standards and unknown samples.  The kit is suitable for serum, plasma, urine, saliva, lysates, and media (see Preparation of Samples) with detection sensitivity limit of ~ 2 µM (in 50 µL sample volume). 

Tris EDTA Saline, 10mM Tris HCl , 1mM EDTA, 2M Nacl

T8150-801 8L
EUR 120

pMXs-GFP-LC3 Retroviral Vector

RTV-801 10 ?g
EUR 1169
Description: Expression vector contains a fusion of GFP and LC3. A separate GFP control vector is also included.

Recombinant (E.Coli) Human Myoglobin

RP-801 500 ug
EUR 408

SARS-CoV-2 (COVID-19) Omicron Variant (B.1.1.529) Spike RBD Recombinant Protein

21-801 0.1 mg
EUR 485
Description: Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biologicalprocesses that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Knownreceptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein ofcoronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Mostnotable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike(S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogenand a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells throughinteraction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizingantibodyand T-cell responses, as well as protective immunity.

Dermatopontin Recombinant Protein

91-801 0.05 mg
EUR 490.25
Description: Dermatopontin, also known as Tyrosine-rich acidic matrix protein, TRAMP and DPT, is a secreted protein which belongs to the dermatopontin family. DPT is expressed in various tissues, such as fibroblasts, heart, skeletal muscle, brain and pancreas. It seems to mediate adhesion by cell surface integrin binding. DPT may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. DPT can enhance TGFB1 activity through interaction with decorin. In addition, DPT accelerates collagen fibril formation, stabilizes collagen fibrils against low-temperature dissociation and inhibits cell proliferation.

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCA0801-250 250uL
EUR 383
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), APC conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCAP0801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCAP0801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC810801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC810801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCB0801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Biotin conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCB0801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Biotin conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC550801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF555 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC550801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF555 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC430801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF543 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC430801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF543 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC470801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF647 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC470801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF647 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC880801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF488A conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC880801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF488A conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC940801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF594 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC940801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF594 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCP0801-250 250uL
EUR 383
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), PerCP conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC040801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405S conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC040801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405S conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC050801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405M conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC050801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF405M conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCR0801-250 250uL
EUR 383
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), RPE conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNUB0801-100 100uL
EUR 209
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Concentration: 0.2mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNUB0801-500 500uL
EUR 458
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Concentration: 0.2mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC680801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF568 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC680801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF568 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC700801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF770 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC700801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF770 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC400801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF640R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC400801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF640R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC610801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF660R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC610801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF660R conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC800801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNC800801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), CF680 conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCH0801-100 100uL
EUR 199
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNCH0801-500 500uL
EUR 544
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

PSA (Prostate Specific Antigen)(KLK3/801) Antibody

BNUM0801-50 50uL
EUR 395
Description: Primary antibody against PSA (Prostate Specific Antigen)(KLK3/801), 1mg/mL

96 WELL WHITE LOW PROFILE PCR MICROPLATE FOR AB

PCR-96-LP-AB-W 25/pk
EUR 388
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

Recombinant Neisseria Gonorrhoeae lptD Protein (aa 1-801)

VAng-Wyb2182-inquire inquire Ask for price
Description: Neisseria Gonorrhoeae (strain ATCC 700825 / FA 1090) LPS-assembly protein lptD, recombinant protein.

Recombinant Streptococcus Pyogenes ftsK Protein (aa 1-801)

VAng-Cr8109-inquire inquire Ask for price
Description: Streptococcus Pyogenes serotype M18 DNA translocase FtsK (ftsK), recombinant protein.

Prostate Specific Antigen (PSA); Clone KLK3/801 (Concentrate)

RA0009-C.1 0.1 ml
EUR 125

Prostate Specific Antigen (PSA); Clone KLK3/801 (Concentrate)

RA0009-C.5 0.5 ml
EUR 300

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCA1256-250 250uL
EUR 383
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), APC conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC811256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF680R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC811256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF680R conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCAP1256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCAP1256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCB1256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Biotin conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCB1256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Biotin conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC471256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF647 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC471256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF647 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC551256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF555 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC551256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF555 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC431256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF543 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC431256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF543 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC881256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF488A conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC881256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF488A conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC941256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF594 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC941256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF594 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCH1256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCH1256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCP1256-250 250uL
EUR 383
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), PerCP conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC041256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405S conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC041256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405S conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNCR1256-250 250uL
EUR 383
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), RPE conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNUB1256-100 100uL
EUR 209
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Concentration: 0.2mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNUB1256-500 500uL
EUR 458
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), Concentration: 0.2mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC681256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF568 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC681256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF568 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC701256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF770 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC701256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF770 conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC051256-100 100uL
EUR 199
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405M conjugate, Concentration: 0.1mg/mL

Prostate Specific Antigen (PSA) (KLK3/801 + KLK3/1248) Antibody

BNC051256-500 500uL
EUR 544
Description: Primary antibody against Prostate Specific Antigen (PSA)(KLK3/801 + KLK3/1248), CF405M conjugate, Concentration: 0.1mg/mL

One of the major metabolite is stirring the amine of 2,2-dimethyl-5-nitro-2H-benzimidazole (named Sepin-1.55). Sepin-concentration in the blood samples was 1.55 Sepin-1 depending on the dose and used for pharmacokinetic analysis Sepin-1. Tmax was about 5-15 minutes.

Karina

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The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Identification of Bioactive Small Molecule Inhibitors of Separase.

Identification of Bioactive Small Molecule Inhibitors of Separase.

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