Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. SEPIN-1 (2,2-dimethyl-5-nitro-2h-benzimidazole-1,3-dioxide) is a powerful sepaase inhibitor that prevents the growth of cancer cells, cell migration and wound healing suggesting that Epin -1 has a great potential to target tumors on the sepaase overexpension. As part of the ind-activatable studies to bring Send-1 to the clinic, we report here the results of a repeated dose pharmacokinetic study of 28 days in rats. Sepin-1 was administered intravenously to Sprague-Dawley rats once a day for 28 days at three different doses (5, 10 and 20 mg / kg).

The blood samples were collected after the dose administration on days 1 and 28. Sepin-1 is unstable in a basic pH phosphate buffered saline solution in an acid buffer such as citrate buffered saline (pH 4.0). The indicated UHPLC-MS analysis was quickly metabolized in vivo. One of the major metabolites was a 2,2-dimethyl-5-nitro-2h-benzimidazole amine adduct (named 655). The concentration of high-1.55 in blood samples was dependent on the dose grade-1 and used for the pharmacokinetic analysis of the sepin-1. Tmax was about 5 to 15 minutes. The data suggest that no completed accumulation-1 has occurred repeated daily dosage and similar exhibitions on the first and last day of assay. The data also suggest a gender difference, namely that female rats have more exposure and clearance slower than male rats.

The data carrier that Fepin-1 is a potential drug candidate that can also be developed to treat overexpressive human tumors separated. Chromosomal segregation begins when the protease of cysteine, separated, clear the SCC1 subunit of the cohesin to the transition of metaphase-anapase. Sepase is inhibited before the metaphase by the tightly linked secure protein, which contains a pseudosubstrate pattern that blocks the active site separated. To study the specificity and regulation of the sepaase substrate, we are developing a recombinant and safe human separation production system. Using this enzyme, we identify a LPE pattern on the separate SCC1 substrate from the cleavage site and is required for quick and specific substrate cleavage.

 

Toxicity study on the sepaase-sepin-1 inhibitor in Sprague-Dawley rats.

Sepin-1 is a small compound that inhibits the enzymatic activity of separation and growth of cancer cells. As part of the ind-activatable studies to develop Sepin-1 as a chemotherapeutic agent, we have profiled the toxicity of spin-1 in Sprague-Dawley rats in a good laboratory practice (GLP). The maximum tolerated dose (MTD) of Sepin-1 in rats is 40 mg / kg in a single dose study and 20 mg / kg in the studied study for 7 consecutive days. The toxicity study consists of two main study and recovery study. Sepin-1 with 0 (control), 5 (low dose), 10 (median dose) and 20 (high dose) mg / kg were administered by an intravenous injection of bolus to rats once a day for 28 consecutive days.

The animals of the main study were euthanized on day 29, while the animals of the recovery study were allowed to recover for 28 days after the 28-day sepin-1 dose before being euthanized on the day 29 of the period out of dose. Although the effects of the final and median doses are minimal, a hematological analysis shows that the dose of the high dose is associated with a decrease in red blood cells and hemoglobin, and increases the number of reticulocytes. and platelets as well as average corpuscular volume. Clinical chemistry indicates that Fepin-1 causes an increase in total bilirubin and a decrease in Kinase creatine. Histopathology analysis indicates that the minimum bone bone bone hyperplasia is hyperplasia, minimal minimal splenic extramary hematoposis, minimal splenic lymphoid exhaustion, minimum thymic lymphoid exhaustion to light minimal lymphatic hyperplasia. minimal at minimal and light lymphoid hyperplasia in male and female rats in the main study.

These abnormal changes are dependent on the dose-1 and especially reversible after a 28-day recovery period in the animals of the recovery study. On the basis of our results, we conclude that Pharmacological Doses Sein-1 (5-10 mg / kg) is well-tolerable, without significant mortality or morbidity, and can be further developed as a new potential drug to treat The sepaase-overexpressed tumors.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.
Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

The coinin subunit variant is identified from the peripheral sclerocornea genealogy.

ScleroCornea is a defiant disturbance that is rarely marked by the turbidity of the cornea. Here, we reported the Chinese family of nonkonsanguineous with some peripheral sclerocornea patients which stretched in three generations inherited in the dominant way of autosomes. This is a retrospective case series from the peripheral sclerocornea genealogy. A comprehensive ophthalmic examination was conducted and assessed in 14 pedigree members. All exome sequencing is used to identify genetic changes in members of the affected genealogy. LimfoBlastoid Cell Line (LCLS) was established using blood samples from family members. Functional tests are carried out with this cell line.

Results
Six affected and eight family members who were not affected by Peripheral Sclerocorno were examined. All affected individuals show Sclerazation features over peripheral cornea from both eyes. Means that the diameter of horizontal and vertical cornea is found significantly decreasing in the affected members. The significant difference was also observed in the average Pachymetry Apex between subjects affected and not affected. This ophthalmic parameter does not resemble Cornea Panaa. The RAD21C1348T variant is identified with the sequencing throughout the exome. Although this variant caused the substitution of RAD21 R450C on Sepeanase cleavage sites, cells from members of the ScleroCornea family did not have mitosis and ploidy defects.

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

4-RPD759Mu01
  • EUR 515.74
  • EUR 241.00
  • EUR 1659.04
  • EUR 619.68
  • EUR 1139.36
  • EUR 408.00
  • EUR 3997.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Glutamate Cysteine Ligase, Catalytic expressed in: E.coli

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

4-RPD759Ra01
  • EUR 521.12
  • EUR 242.00
  • EUR 1679.20
  • EUR 626.40
  • EUR 1152.80
  • EUR 412.00
  • EUR 4048.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Glutamate Cysteine Ligase, Catalytic expressed in: E.coli

Escherichia coli Glutamate--cysteine ligase (gshA)

1-CSB-EP363915ENV
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli Glutamate--cysteine ligase(gshA) expressed in E.coli

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx112753
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx103829
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx103830
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx103831
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate-Cysteine Ligase, Modifier Subunit (Recombinant)

20-abx073358
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

Glutamate-Cysteine Ligase, Modifier Subunit Antibody

20-abx137266
  • EUR 704.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 20 ug
  • 5 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx176619
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx172573
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Glutamate--Cysteine Ligase (GSHA) Antibody (HRP)

20-abx300735
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate--Cysteine Ligase (GSHA) Antibody (FITC)

20-abx300736
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate--Cysteine Ligase (GSHA) Antibody (Biotin)

20-abx300737
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx327236
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Recombinant Glutamate Cysteine Ligase, Modifier Subunit (GCLM)

4-RPB038Hu01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Glutamate Cysteine Ligase, Modifier Subunit expressed in: E.coli

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx128899
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx121482
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx112754
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx338833
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx004063
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) Protein

20-abx066811
  • EUR 718.00
  • EUR 286.00
  • EUR 2235.00
  • EUR 857.00
  • EUR 509.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Glutamate Cysteine Ligase, Catalytic (GCLC) Protein

20-abx066812
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) Protein

20-abx066813
  • EUR 732.00
  • EUR 286.00
  • EUR 2263.00
  • EUR 871.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

abx034226-400ul 400 ul
EUR 523

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

abx034226-80l 80 µl
EUR 286

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

abx233387-100ug 100 ug
EUR 481

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx176620
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx176621
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx176622
  • EUR 1247.00
  • EUR 592.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx172574
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx172575
  • EUR 871.00
  • EUR 453.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx329936
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Mouse Glutamate Cysteine Ligase, Modifier Subunit (GCLM)

QY-E21750 96T
EUR 374

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-10x96wellstestplate 10x96-wells test plate
EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-1x48wellstestplate 1x48-wells test plate
EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-1x96wellstestplate 1x96-wells test plate
EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-5x96wellstestplate 5x96-wells test plate
EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

4-SED759Mu
  • EUR 4913.00
  • EUR 2595.00
  • EUR 655.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-10x96wellstestplate 10x96-wells test plate
EUR 5124.2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-1x48wellstestplate 1x48-wells test plate
EUR 509.64
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-1x96wellstestplate 1x96-wells test plate
EUR 685.2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-5x96wellstestplate 5x96-wells test plate
EUR 2783.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

4-SED759Ra
  • EUR 5175.00
  • EUR 2734.00
  • EUR 686.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody (Human)

4-PAD759Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glutamate Cysteine Ligase, Catalytic (GCLC)

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody (Mouse)

4-PAD759Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glutamate Cysteine Ligase, Catalytic (GCLC)

Mouse Glutamate Cysteine Ligase, Catalytic ELISA Kit (GCLC)

RK02837 96 Tests
EUR 521

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Mu-48Tests 48 Tests
EUR 533

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Mu-96Tests 96 Tests
EUR 740

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Ra-48Tests 48 Tests
EUR 557

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Ra-96Tests 96 Tests
EUR 775

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Mu-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Mu-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

abx572561-96tests 96 tests
EUR 668

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

abx573605-96tests 96 tests
EUR 668

Human Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

abx516753-96tests 96 tests
EUR 668

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody (HRP)

20-abx335823
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody (FITC)

20-abx335824
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody (Biotin)

20-abx335825
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) CLIA Kit

20-abx494372
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) CLIA Kit

20-abx494373
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Protein

20-abx653557
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Protein

20-abx653558
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Protein

20-abx653559
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Protein

20-abx166647
  • EUR 662.00
  • EUR 272.00
  • EUR 2040.00
  • EUR 787.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Blocking Peptide

20-abx162452
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

20-abx154063
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

20-abx155562
  • EUR 7237.00
  • EUR 3855.00
  • EUR 895.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Mu-48Tests 48 Tests
EUR 557

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Mu-96Tests 96 Tests
EUR 774

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Ra-48Tests 48 Tests
EUR 583

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Ra-96Tests 96 Tests
EUR 811

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

QY-E11835 96T
EUR 374

Rat Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E02G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E02G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E02G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E02G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E02G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E02G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E09G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E09G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E09G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E09G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E09G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E09G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E01G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E01G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E01G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E01G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E01G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E01G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E04G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E04G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E04G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E04G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E04G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E04G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E03G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E03G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E03G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E03G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E03G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E03G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E07G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E07G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E07G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E07G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E07G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E07G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E06G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E06G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E06G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E06G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E06G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E06G0106-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E08G0104-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E08G0104-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase Catalytic subunit ELISA kit

E08G0104-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase Catalytic subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E08G0106-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E08G0106-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Conclusion
We reported a peripheral sclerocorno family without connection with Cornea Plana. RAD21 variant found cosegregating with peripheral sclerocornea. Our results show that the RAD21 function, in addition to the cell cycle and the regulation of chromosome separation, can underline the peripheral catocornea pathogenesis.

Karina

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