Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Sepased, an enzyme for resolving the cohesion of Chromatide Sister, is an oncogene and overexpressed in many human cancer. SEPIN-1 (2,2-dimethyl-5-nitro-2h-benzimidazole-1,3-dioxide) is a powerful sepaase inhibitor that prevents the growth of cancer cells, cell migration and wound healing suggesting that Epin -1 has a great potential to target tumors on the sepaase overexpension. As part of the ind-activatable studies to bring Send-1 to the clinic, we report here the results of a repeated dose pharmacokinetic study of 28 days in rats. Sepin-1 was administered intravenously to Sprague-Dawley rats once a day for 28 days at three different doses (5, 10 and 20 mg / kg).

The blood samples were collected after the dose administration on days 1 and 28. Sepin-1 is unstable in a basic pH phosphate buffered saline solution in an acid buffer such as citrate buffered saline (pH 4.0). The indicated UHPLC-MS analysis was quickly metabolized in vivo. One of the major metabolites was a 2,2-dimethyl-5-nitro-2h-benzimidazole amine adduct (named 655). The concentration of high-1.55 in blood samples was dependent on the dose grade-1 and used for the pharmacokinetic analysis of the sepin-1. Tmax was about 5 to 15 minutes. The data suggest that no completed accumulation-1 has occurred repeated daily dosage and similar exhibitions on the first and last day of assay. The data also suggest a gender difference, namely that female rats have more exposure and clearance slower than male rats.

The data carrier that Fepin-1 is a potential drug candidate that can also be developed to treat overexpressive human tumors separated. Chromosomal segregation begins when the protease of cysteine, separated, clear the SCC1 subunit of the cohesin to the transition of metaphase-anapase. Sepase is inhibited before the metaphase by the tightly linked secure protein, which contains a pseudosubstrate pattern that blocks the active site separated. To study the specificity and regulation of the sepaase substrate, we are developing a recombinant and safe human separation production system. Using this enzyme, we identify a LPE pattern on the separate SCC1 substrate from the cleavage site and is required for quick and specific substrate cleavage.

 

Toxicity study on the sepaase-sepin-1 inhibitor in Sprague-Dawley rats.

Sepin-1 is a small compound that inhibits the enzymatic activity of separation and growth of cancer cells. As part of the ind-activatable studies to develop Sepin-1 as a chemotherapeutic agent, we have profiled the toxicity of spin-1 in Sprague-Dawley rats in a good laboratory practice (GLP). The maximum tolerated dose (MTD) of Sepin-1 in rats is 40 mg / kg in a single dose study and 20 mg / kg in the studied study for 7 consecutive days. The toxicity study consists of two main study and recovery study. Sepin-1 with 0 (control), 5 (low dose), 10 (median dose) and 20 (high dose) mg / kg were administered by an intravenous injection of bolus to rats once a day for 28 consecutive days.

The animals of the main study were euthanized on day 29, while the animals of the recovery study were allowed to recover for 28 days after the 28-day sepin-1 dose before being euthanized on the day 29 of the period out of dose. Although the effects of the final and median doses are minimal, a hematological analysis shows that the dose of the high dose is associated with a decrease in red blood cells and hemoglobin, and increases the number of reticulocytes. and platelets as well as average corpuscular volume. Clinical chemistry indicates that Fepin-1 causes an increase in total bilirubin and a decrease in Kinase creatine. Histopathology analysis indicates that the minimum bone bone bone hyperplasia is hyperplasia, minimal minimal splenic extramary hematoposis, minimal splenic lymphoid exhaustion, minimum thymic lymphoid exhaustion to light minimal lymphatic hyperplasia. minimal at minimal and light lymphoid hyperplasia in male and female rats in the main study.

These abnormal changes are dependent on the dose-1 and especially reversible after a 28-day recovery period in the animals of the recovery study. On the basis of our results, we conclude that Pharmacological Doses Sein-1 (5-10 mg / kg) is well-tolerable, without significant mortality or morbidity, and can be further developed as a new potential drug to treat The sepaase-overexpressed tumors.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.
Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

The coinin subunit variant is identified from the peripheral sclerocornea genealogy.

ScleroCornea is a defiant disturbance that is rarely marked by the turbidity of the cornea. Here, we reported the Chinese family of nonkonsanguineous with some peripheral sclerocornea patients which stretched in three generations inherited in the dominant way of autosomes. This is a retrospective case series from the peripheral sclerocornea genealogy. A comprehensive ophthalmic examination was conducted and assessed in 14 pedigree members. All exome sequencing is used to identify genetic changes in members of the affected genealogy. LimfoBlastoid Cell Line (LCLS) was established using blood samples from family members. Functional tests are carried out with this cell line.

Results
Six affected and eight family members who were not affected by Peripheral Sclerocorno were examined. All affected individuals show Sclerazation features over peripheral cornea from both eyes. Means that the diameter of horizontal and vertical cornea is found significantly decreasing in the affected members. The significant difference was also observed in the average Pachymetry Apex between subjects affected and not affected. This ophthalmic parameter does not resemble Cornea Panaa. The RAD21C1348T variant is identified with the sequencing throughout the exome. Although this variant caused the substitution of RAD21 R450C on Sepeanase cleavage sites, cells from members of the ScleroCornea family did not have mitosis and ploidy defects.

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx103831
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx176619
  • EUR 1479.60
  • EUR 710.40
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx172573
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx327236
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Glutamate Cysteine Ligase, Catalytic (GCLC) Antibody

20-abx112753
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Rat Glutamate Cysteine Ligase Catalytic ELISA Kit

IRTGCLCKT each
EUR 790
Description: Rat Glutamate Cysteine Ligase Catalytic ELISA Kit

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

4-RPD759Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Glutamate Cysteine Ligase, Catalytic expressed in: E.coli

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

4-RPD759Mu01
  • EUR 618.89
  • EUR 289.20
  • EUR 1990.85
  • EUR 743.62
  • EUR 1367.23
  • EUR 489.60
  • EUR 4797.12
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Glutamate Cysteine Ligase, Catalytic expressed in: E.coli

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

4-RPD759Ra01
  • EUR 625.34
  • EUR 290.40
  • EUR 2015.04
  • EUR 751.68
  • EUR 1383.36
  • EUR 494.40
  • EUR 4857.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Glutamate Cysteine Ligase, Catalytic expressed in: E.coli

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41637-100ug 100ug
EUR 570.9

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41637-1mg 1mg
EUR 2533.7

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41637-50ug 50ug
EUR 459.8

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41638-100ug 100ug
EUR 492.8

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41638-1mg 1mg
EUR 2184

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41638-50ug 50ug
EUR 396

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41639-100ug 100ug
EUR 578.6

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41639-1mg 1mg
EUR 2566.2

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU41639-50ug 50ug
EUR 465.3

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU57236-100ug 100ug
EUR 470.4

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU57236-1mg 1mg
EUR 2184

Recombinant Glutamate Cysteine Ligase, Catalytic (GCLC)

RPU57236-50ug 50ug
EUR 385

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

abx233387-100ug 100 ug
EUR 577.2

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx176620
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx176621
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx176622
  • EUR 1496.40
  • EUR 710.40
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx172574
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx172575
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx121482
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx112754
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

abx034226-400ul 400 ul
EUR 627.6

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

abx034226-80l 80 µl
EUR 343.2

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx128899
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx338833
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx329936
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody

20-abx004063
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mouse Glutamate Cysteine Ligase Catalytic ELISA Kit

IMSGCLCKT each
EUR 752
Description: Mouse Glutamate Cysteine Ligase Catalytic ELISA Kit

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) Protein

20-abx066813
  • EUR 878.40
  • EUR 343.20
  • EUR 2715.60
  • EUR 1045.20
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Glutamate Cysteine Ligase, Modifier Subunit (GCLM)

QY-E21750 96T
EUR 448.8

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody

CAU23117-100ul 100ul
EUR 255.4

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody

CAU23117-200ul 200ul
EUR 319.2

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody

CAU23118-100ul 100ul
EUR 241.9

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody

CAU23118-200ul 200ul
EUR 302.4

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody

CAU23119-100ul 100ul
EUR 235.2

Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody

CAU23119-200ul 200ul
EUR 294

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) Protein

20-abx066811
  • EUR 861.60
  • EUR 343.20
  • EUR 2682.00
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Glutamate Cysteine Ligase, Catalytic (GCLC) Protein

20-abx066812
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) CLIA Kit

20-abx494373
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody (HRP)

20-abx335823
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

20-abx155562
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

abx573605-96tests 96 tests
EUR 801.6

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SL1691Ra - Ask for price

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKN45544-48T 48T
EUR 410.83

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKN45544-5x96T 5x96T
EUR 2787.78

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKN45544-96T 96T
EUR 586.9

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKU04433-48T 48T
EUR 603.26

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKU04433-5x96T 5x96T
EUR 4093.55

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKU04433-96T 96T
EUR 861.8

Rat GCLC(Glutamate Cysteine Ligase, Catalytic) ELISA Kit

ELK6793-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GCLC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat GCLC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat GCLC in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat GCLC(Glutamate Cysteine Ligase, Catalytic) ELISA Kit

ELK6793-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GCLC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat GCLC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat GCLC in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Ra-48Tests 48 Tests
EUR 699.6

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Ra-96Tests 96 Tests
EUR 973.2

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

QY-E11835 96T
EUR 448.8

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Ra-48Tests 48 Tests
EUR 668.4

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Ra-96Tests 96 Tests
EUR 930

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Ra-48T 48T
EUR 512.09
Description: serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Ra-96T 96T
EUR 731.54
Description: serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DL-GCLC-Ra 96T
EUR 475
Description: serum, plasma, tissue homogenates or other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Ra 96T
EUR 499
Description: serum, plasma, tissue homogenates or other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-10x96wellstestplate 10x96-wells test plate
EUR 6149.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-1x48wellstestplate 1x48-wells test plate
EUR 611.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-1x96wellstestplate 1x96-wells test plate
EUR 822.24
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Ra-5x96wellstestplate 5x96-wells test plate
EUR 3340.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

4-SED759Ra
  • EUR 6210.00
  • EUR 3280.80
  • EUR 823.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Ra-48T 48T
EUR 487.7
Description: serum, plasma, tissue homogenates and other biological fluids.

Rat Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Ra-96T 96T
EUR 696.7
Description: serum, plasma, tissue homogenates and other biological fluids.

Glutamate Cysteine Ligase, Modifier Subunit (GCLM) Antibody (FITC)

20-abx335824
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) CLIA Kit

20-abx494372
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

20-abx154063
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E02G0106-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E02G0106-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E02G0106-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

abx572561-96tests 96 tests
EUR 801.6

Human Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

abx516753-96tests 96 tests
EUR 801.6

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates or other biological fluids.

Pig Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E07G0106-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E07G0106-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E07G0106-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E08G0106-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E08G0106-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E08G0106-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Glutamate Cysteine Ligase, Modifier Subunit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SL2416Hu 96 Tests
EUR 468

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKN45543-48T 48T
EUR 389.62

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKN45543-5x96T 5x96T
EUR 2643.85

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKN45543-96T 96T
EUR 556.6

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKU04432-48T 48T
EUR 571.55

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKU04432-5x96T 5x96T
EUR 3878.38

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

EKU04432-96T 96T
EUR 816.5

Human GCLC(Glutamate Cysteine Ligase, Catalytic) ELISA Kit

ELK8717-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GCLC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human GCLC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GCLC in the samples is then determined by comparing the OD of the samples to the standard curve.

Human GCLC(Glutamate Cysteine Ligase, Catalytic) ELISA Kit

ELK8717-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GCLC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human GCLC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GCLC in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Mu-48Tests 48 Tests
EUR 668.4

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Mu-96Tests 96 Tests
EUR 928.8

Mouse Glutamate Cysteine Ligase, Catalytic ELISA Kit (GCLC)

RK02837 96 Tests
EUR 625.2

Mouse GCLC(Glutamate Cysteine Ligase, Catalytic) ELISA Kit

ELK6361-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GCLC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse GCLC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse GCLC in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse GCLC(Glutamate Cysteine Ligase, Catalytic) ELISA Kit

ELK6361-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GCLC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GCLC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse GCLC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse GCLC in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Mu-48Tests 48 Tests
EUR 639.6

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Mu-96Tests 96 Tests
EUR 888

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Mu-48T 48T
EUR 487.52
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RDR-GCLC-Mu-96T 96T
EUR 696.47
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DL-GCLC-Mu 96T
EUR 453
Description: serum, plasma, tissue homogenates or other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

DLR-GCLC-Mu 96T
EUR 475
Description: serum, plasma, tissue homogenates or other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

SED759Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

4-SED759Mu
  • EUR 5895.60
  • EUR 3114.00
  • EUR 786.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Glutamate Cysteine Ligase, Modifier Subunit ELISA kit

E01A13458 96T
EUR 700
Description: ELISA

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Mu-48T 48T
EUR 464.3
Description: serum, plasma, tissue homogenates and other biological fluids.

Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit

RD-GCLC-Mu-96T 96T
EUR 663.3
Description: serum, plasma, tissue homogenates and other biological fluids.

Recombinant Glutamate Cysteine Ligase, Modifier Subunit (GCLM)

4-RPB038Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Glutamate Cysteine Ligase, Modifier Subunit expressed in: E.coli

Conclusion
We reported a peripheral sclerocorno family without connection with Cornea Plana. RAD21 variant found cosegregating with peripheral sclerocornea. Our results show that the RAD21 function, in addition to the cell cycle and the regulation of chromosome separation, can underline the peripheral catocornea pathogenesis.

Karina

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