Structure and Function of the Separase-Securin Complex

Structure and Function of the Separase-Securin Complex

Sepaase is a large protease of cysteine ​​in eukaryotes and presents crucial roles in many cell processes, in particular chromosomal segregation during mitosis and meiosis, apoptosis, damage repair of DNA, from the disengagement of the centrosome and duplication, stabilization and elongation of the spindle. It dissolves the cohesion between sister chromatids by cleaving one of the subheadings of the cohesin ring for chromosome segregation. The sepaase activity is tightly controlled at several levels, by the direct binding of inhibitory proteins as well as the post-procedure modification. The dysregulation of SEARAISE business is related to cancer and genome instability, making it a drug discovery target. One of the most famous sepaase inhibitors is securin, which has been identified in yeast, plants and animals.

Securin forms a tight complex with sepaase and inhibits porceously its catalytic activity. The recent structures of the Sepase-Securin complex revealed the molecular mechanism of the safety inhibitor activity. A segment of securin is linked in the active sepaase site, thus blocking the substrate bonding. Securin itself is not cleaved by Separase because its link mode is not compatible with catalysis. Securin also has extensive interactions with sepaase outside the active site, according to its chaperone function to stabilize this enzyme. In several species, including Xenopus, the mouse and the man, two members of the Cyclin family have been identified. Cyclin A2, which is expressed ubiquitously in dividing cells and plays a role in the replication of DNA, entry into mitosis and the spindle assembly and cyclin A1, whose function is less clear and which is expressed in spermatocytes, leukemia cells and postmicathic multicile cells.

The suppression of the gene has shown that cyclin A1 is essential for masculine meiosis, but not essential for female meiosis. Our results revealed that the cyclin A1 is not only dispensable in the oocytes, we show here that its expression is actually undesirable in these cells. Our data demonstrate that CPA / C and oocyte proteasome are unable to target the cyclin A1 sufficiently prior to anchhase, which causes an arrest of anaphase and a direct inhibition of separation.

 

 

Separation of chromosomes during the masculine meiosis of Drosophila, I need a separate-mediated cleavage of the Uno homologous conjunction protein

 

Regular chromosomal segregation during the first meotic division requires a preliminary matching of homologous chromosomes in bivalent. During canonical meiosis, the bond between homologous chromosomes is maintained until the end of the metaphase I by chiasmata resulting from metiotic recombination in combination with a distal sister chromatide cohesion. Sepased removal of the cohesin of the chromosome arms at the end of the metaphase I allows the resolution of the chiasmata and the homologation to opposite spindle poles during an anaphase I. is interesting, sepaase is also required for The bivalent division during meiosis I in the males of Drosophila, where counterparts are jointly by an alternative mechanism independent of meiotic recombination and cohesin.

Here, we indicate the identification of a new alternative homologous conjunction protein encoded by previously increed genes uniforms only (UNO). Univalent in non-zero mutants at the beginning of meiosis I, instead of normal bivalents, are randomly separated. In the wild type, the UNO protein is detected in points associated with bivalent chromosomes and most abundantly at the localized twinning site of sexual chromosomes. Uno is cleaved by sepaase.

The expression of a single-mutant version with a non-functional sepaase cleavage site restores the counterpart of the homologous conjunction in a bottom of the UNO null. However, the separation of bivalent during meiosis, I am completely repealed by this unravelful version of the United Nations. Therefore, we propose that the homologous separation during the male meiosis of Drosophila is triggered by a separately-mediated divide of the UNO.

 Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease

Centrosometive reduction of newly generated tetraploid cancer cells obtained by depletion of separation

 

Tetraploidy, a common characteristic of cancer, leads to the presence of additional centrosomes, associated with chromosomal instability (CIN) and aneuploidy. Deregulation in the number of centricsomes triggers tumorigenesis. However, how to evolve supernumerary centrics when the emergence of tetraploid cells remains elucidated. Here, generating tetraploid isogenic clones in colorectal cancer and in unprocessed cells, we show that almost tetraploid clones have a significant increase in the number of centricsomes. In addition, we find that the centrous region in quasi-tetraploids is twice as big as in the almost diploids. To assess whether the centrosome clustering would occur, we then analyzed the number of hundreds revealing the amplification of the hundred. Nevertheless, more than half of the quasi-tetraploids maintained in the culture do not have centrosomal aberrations. To determine if the cells have gradually lost the hundreds after becoming near tetraploids, we transfer transfected diploid cells with SIRNA against espl1 / separase, a protease responsible for triggering an anaphase, in order to generate newly tetraploid cells.

Finally, using this model, we evaluated the number of hundreds at different points of time after the tetrapolisation of the search for quasi-tetraploid rapidly losing centrosomes over time. Taken together, these data demonstrate that, although most cells reduce supernumerary centrosomes after tetrapolisation, a small fraction retains additional cottages, which potentially leads to CIN. The arrest of cyclin-induced cell cycle A1 is specific to the oocytes and the presence of cyclin A1 in early embryos has no effect on the progression of the cell cycle or the chromosomal division.

Separase (pS801) Blocking Peptide

20-abx162232
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  • 1 mg
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Growth Blocking Peptide

046-92 100 μg
EUR 255.96

Growth Blocking Peptide - FAM Labeled

FG-046-92A 1 nmol
EUR 336.96

Growth Blocking Peptide - Biotin Labeled

B-046-92 20 μg
EUR 336.96

Growth Blocking Peptide - Rhodamine Labeled

FR-046-92 1 nmol
EUR 336.96

Growth Blocking Peptide - I-125 Labeled

T-046-92 10 μCi
EUR 1145.88

Separase Antibody

20-abx121903
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  • 100 ul
  • 200 ul
  • 30 ul

Separase Antibody

44415-100ul 100ul
EUR 302.4

Separase Antibody

44415-50ul 50ul
EUR 224.4

Separase Antibody

20-abx215242
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  • 100 ug
  • 50 ug

Separase Antibody

E18-9195-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Separase Antibody

E18-9195-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Separase Antibody

E38PA4405 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE antibody

70R-31054 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody

Separase antibody

70R-51689 100 ul
EUR 286
Description: Purified Polyclonal Separase antibody

Separase Antibody

AF9195 200ul
EUR 420

Separase Antibody

AF9195-100ul 100ul
EUR 280

Separase Antibody

AF9195-200ul 200ul
EUR 350

Separase Antibody

ABF9195 100 ug
EUR 525.6

SEP15 Blocking Peptide

DF8136-BP 1mg
EUR 234

Separase (pS801) Antibody

20-abx134111
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SEPARASE antibody (Ser801)

70R-31053 100 ug
EUR 294
Description: Rabbit polyclonal SEPARASE antibody (Ser801)

SEPN1 Blocking Peptide

33R-1411 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPN1 antibody, catalog no. 70R-8737

SEPN1 Blocking Peptide

33R-6938 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPN1 antibody, catalog no. 70R-8738

Sepn1 Blocking Peptide

33R-9577 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Sepn1 antibody, catalog no. 70R-8739

SEPP1 Blocking Peptide

33R-4984 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPP1 antibody, catalog no. 70R-2714

SEPP1 Blocking Peptide

DF8258-BP 1mg
EUR 234

SEPT5 Blocking Peptide

DF9881-BP 1mg
EUR 234

SEPT9 Blocking Peptide

DF12229-BP 1mg
EUR 234

SEPT3 Blocking Peptide

DF4241-BP 1mg
EUR 234

SEPT2 Blocking Peptide

DF4458-BP 1mg
EUR 234

SEPT6 Blocking Peptide

DF4459-BP 1mg
EUR 234

SEPT7 Blocking Peptide

DF4460-BP 1mg
EUR 234

SEPHS1 Blocking Peptide

33R-7181 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPHS1 antibody, catalog no. 70R-1203

SEPT11 Blocking Peptide

DF9880-BP 1mg
EUR 234

SEPT10 Blocking Peptide

DF2233-BP 1mg
EUR 234

SEPT14 Blocking Peptide

DF4457-BP 1mg
EUR 234

SEPARASE Cell ELISA Kit

abx595539-96tests 96 tests
EUR 764.4

SEPARASE Cell ELISA Kit

abx595539-100g 100 µg Ask for price

SEPARASE Cell ELISA Kit

abx595539-10g 10 µg
EUR 493.75

SEPARASE Cell ELISA Kit

abx595539-50g 50 µg Ask for price

Separase Polyclonal Antibody

ABP52424-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

ABP52424-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Separase from Human, Mouse. This Separase antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Separase around the non-phosphorylation site of S801

Separase Polyclonal Antibody

E20-74243 100ug
EUR 225
Description: Available in various conjugation types.

Separase Conjugated Antibody

C44415 100ul
EUR 476.4

Separase Polyclonal Antibody

E44H02168 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

SEPARASE (Ab-801) Antibody

8B0086 50ug
EUR 368
Description: SEPARASE (Ab-801) Antibody

SEPARASE (Ab-801) Antibody

E11-0086B 100μg
EUR 225
Description: Available in various conjugation types.

Septin 1 Blocking Peptide

20-abx061705
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  • 1 mg
  • 5 mg

Septin 7 Blocking Peptide

20-abx062385
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  • 1 mg
  • 5 mg

Septin 11 Blocking Peptide

33R-5793 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT11 antibody, catalog no. 70R-5568

Septin 2 Blocking Peptide

33R-6451 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT2 antibody, catalog no. 70R-5632

Septin 2 Blocking Peptide

33R-5309 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT2 antibody, catalog no. 70R-5633

Septin 12 Blocking Peptide

33R-5333 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT12 antibody, catalog no. 70R-5540

Septin 9 Blocking Peptide

33R-9702 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT9 antibody, catalog no. 70R-3525

Septin 8 Blocking Peptide

20-abx161242
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  • 1 mg
  • 5 mg

Septin 1 Blocking Peptide

AF9196-BP 1mg
EUR 234

Septin 8 Blocking Peptide

AF9197-BP 1mg
EUR 234

Septin 6 (SEPT6) Blocking Peptide

20-abx063761
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  • 1 mg
  • 5 mg

Septin 3 (SEPT3) Blocking Peptide

20-abx161762
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  • 1 mg
  • 5 mg

Separase (A795) polyclonal antibody

E43P0374 100ul
EUR 225
Description: Available in various conjugation types.

SEPARASE (Phospho-Ser801) Antibody

8A0086 50ug
EUR 368
Description: SEPARASE (Phospho-Ser801) Antibody

SEPARASE (Phospho-Ser801) Antibody

E11-0086A 100μg
EUR 225
Description: Available in various conjugation types.

SEPARASE Cell-Based ELISA Kit

EKA50537-5x96T 5x96T
EUR 2122.78

SEPARASE Cell-Based ELISA Kit

EKA50537-96T 96T
EUR 446.9

Separase Rabbit Polyclonal Antibody

ES3423-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Separase Rabbit Polyclonal Antibody

ES3423-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Separase from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Rabbit Polyclonal Separase Antibody

TA309645 100 µl Ask for price

Separase (phospho Ser801) Rabbit pAb

E2252078 100ul
EUR 225
Description: Available in various conjugation types.

40787 Blocking Peptide

33R-2900 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT1 antibody, catalog no. 70R-9926

hCG_1982709 Blocking Peptide

33R-3437 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1982709 antibody, catalog no. 70R-9054

hCG_2042202 Blocking Peptide

33R-3770 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2042202 antibody, catalog no. 70R-9063

hCG_1660138 Blocking Peptide

33R-4078 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1660138 antibody, catalog no. 70R-9044

hCG_1646157 Blocking Peptide

33R-4162 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9034

hCG_20426 Blocking Peptide

33R-5875 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8775

HCG_1745121 Blocking Peptide

33R-6558 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1745121 antibody, catalog no. 70R-3903

hCG_1646157 Blocking Peptide

33R-7420 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9035

hCG_20426 Blocking Peptide

33R-4753 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8776

hCG_2007354 Blocking Peptide

33R-5366 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2007354 antibody, catalog no. 70R-9061

Ub Blocking Peptide

20-abx063395
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  • 1 mg
  • 5 mg

F7 Blocking Peptide

33R-1026 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DLG4 antibody, catalog no. 70R-4080

GC Blocking Peptide

33R-10350 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10252

A1 Blocking Peptide

33R-10744 50 ug
EUR 145
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802

KC Blocking Peptide

33R-11041 50 ug
EUR 145
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298

F2 Blocking Peptide

33R-1783 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F2 antibody, catalog no. 70R-8514

PB Blocking Peptide

33R-2067 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of pb antibody, catalog no. 70R-2192

AC Blocking Peptide

33R-3003 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ac antibody, catalog no. 70R-1978

TH Blocking Peptide

33R-3167 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-7854

F8 Blocking Peptide

33R-3569 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F8 antibody, catalog no. 70R-9971

NP Blocking Peptide

33R-3631 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NP antibody, catalog no. 70R-2286

GC Blocking Peptide

33R-4418 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10253

GK Blocking Peptide

33R-5595 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GK antibody, catalog no. 70R-4533

TH Blocking Peptide

33R-6309 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-10442

HB Blocking Peptide

33R-6336 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hb antibody, catalog no. 70R-3198

N Blocking Peptide

33R-6561 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSM8 antibody, catalog no. 70R-4590

SI Blocking Peptide

33R-6891 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7205

XK Blocking Peptide

33R-7655 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7274

F7 Blocking Peptide

33R-7835 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F7 antibody, catalog no. 70R-9970

PC Blocking Peptide

33R-8614 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PC antibody, catalog no. 70R-9828

XK Blocking Peptide

33R-5017 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7169

SI Blocking Peptide

33R-5258 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7230

A1 Blocking Peptide

3401BP-50 each
EUR 183.6

FX Blocking Peptide

20-abx161511
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  • 1 mg
  • 5 mg

GW Blocking Peptide

20-abx162574
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  • 1 mg
  • 5 mg

AR Blocking Peptide

DF6783-BP 1mg
EUR 234

MB Blocking Peptide

DF7358-BP 1mg
EUR 234

FH Blocking Peptide

DF7460-BP 1mg
EUR 234

C5 Blocking Peptide

DF7719-BP 1mg
EUR 234

GC Blocking Peptide

DF7840-BP 1mg
EUR 234

TG Blocking Peptide

DF7885-BP 1mg
EUR 234

F5 Blocking Peptide

DF8265-BP 1mg
EUR 234

Ob Blocking Peptide

DF8583-BP 1mg
EUR 234

ST Blocking Peptide

DF8616-BP 1mg
EUR 234

CP Blocking Peptide

DF9369-BP 1mg
EUR 234

C7 Blocking Peptide

DF9410-BP 1mg
EUR 234

F3 Blocking Peptide

DF6400-BP 1mg
EUR 234

HP Blocking Peptide

DF6467-BP 1mg
EUR 234

F9 Blocking Peptide

DF6474-BP 1mg
EUR 234

OR Blocking Peptide

DF10250-BP 1mg
EUR 234

C6 Blocking Peptide

DF3963-BP 1mg
EUR 234

C9 Blocking Peptide

DF3964-BP 1mg
EUR 234

MB Blocking Peptide

DF4194-BP 1mg
EUR 234

NT Blocking Peptide

DF4245-BP 1mg
EUR 234

GK Blocking Peptide

DF3151-BP 1mg
EUR 234

PC Blocking Peptide

DF4364-BP 1mg
EUR 234

T Blocking Peptide

BF0015-BP 1mg
EUR 234

E7 Blocking Peptide

BF0311-BP 1mg
EUR 234

AR Blocking Peptide

BF0418-BP 1mg
EUR 234

PR Blocking Peptide

BF0581-BP 1mg
EUR 234

RB Blocking Peptide

BF0614-BP 1mg
EUR 234

ER Blocking Peptide

BF0674-BP 1mg
EUR 234

KC Blocking Peptide

5212BP-50 each
EUR 183.6

GR Blocking Peptide

AF5004-BP 1mg
EUR 234

GK Blocking Peptide

AF0829-BP 1mg
EUR 234

GR Blocking Peptide

AF6066-BP 1mg
EUR 234

GR Blocking Peptide

AF6067-BP 1mg
EUR 234

TK Blocking Peptide

AF6068-BP 1mg
EUR 234

IR Blocking Peptide

AF6098-BP 1mg
EUR 234

Cyclin A1 is therefore not only a large cellular cycle regulator with germinal-biased expression, essential for men and damaging for female meiosis, persistent expression during anaphase in oocytes shows fundamental differences between APC / C in early ecytes and embryos.

Karina

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