Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

Separation of sister chromatids during the eukaryotic cell cycle time with the spindle assembly checkpoint (SAC) and finally triggered when cutting separase-mediation cohesin1-3 cohesion. Silencing of SAC during metaphase activate ubiquitin ligase APC / C (anaphase promoting complex, also known as cyclosome) and results in the destruction of securin1 separase proteasomal inhibitor. In the absence of securin, separate the chromosomes of mammals are still on schedule, but it is unclear how separase regulated in this conditions4,5.

Here we show that human shugoshin 2 (SGO2), an important patron of the meiotic cohesin with unknown function in the soma6,7, turned into separase obstacle in relations with MAD2 SAC-activated. SGO2-MAD2 can functionally replace most separase securin and locked up in a cell securin-KO. acute loss of securin and SGO2, but not both individual proteins, resulting in deregulation separase associated with premature cohesin cleavage and cytotoxicity. Similar to securin8,9, SGO2 is a competitive inhibitor which uses pseudo-substrate sequence to block the active site of separase.

APC / C-dependent ubiquitylation and actions of AAA-ATPase TRIP13 in conjunction with a special adapter p31comet MAD2 liberate separase of SGO2-MAD2 in vitro. Latter mechanism facilitates a considerable degree of separation of sister chromatids in securin-KO cells lacking the activity of APC / C. Thus, our results identify an unexpected function of SGO2 within mitotically dividing cells and regulatory mechanisms that are independent of securin separase but still supervised by SAC the.

Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.
Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

Intertwined functions of Separase and Caspase at the Cell and Programmed cell death.

chromatid separation in time, promoted by separase, is essential for faithful chromosome segregation. Separase is a member of the clan CD cysteine ​​proteases, which also includes pro-apoptotic enzymes known as caspases. We reported a role for C. elegans separase SEP-1, primarily known as an important activity in cell division and cortical granule exocytosis, programmed cell death development when the dominant pro-apoptotic CED-3 caspase compromised. Losing SEP-1 results in an extra surviving cells in weak ced-3 (-) mutant, and suppress lethal mutant embryos from defects for suppressing apoptosis ced-9 / Bcl-2 involving SEP-1 in the execution of apoptosis.

We also report non-apoptotic role clear to CED-3 in promoting the proliferation of germ cells, meiotic chromosome disjunction, the formation of egg shells, and the normal rate of embryo development. In addition, the loss of soma-specific (CSP-3) and the germline-specific inhibitor (CSP-2) generate CED-3 caspase-dependent suppression of lethal embryos and meiotic chromosome non-disjunction respectively, when separase function is compromised.

So, while caspases and separases have evolved specificity of different substrates associated with specific functions they are in apoptosis and cell division each, they seem to have retained the ability residual to participate in the process, supporting the view that the co-option component in cell division may have led to innovations programmed cell suicide in early metazoan evolution. mitotic kinase initial degradation is therefore important to prevent the activation of apoptosis on scheduled separase in metaphase.

MAP4K4 (pS801) Antibody

abx031987-400l 400 µl
EUR 518.75

Separase (pS801) Antibody

20-abx134111
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Separase (pS801) Blocking Peptide

20-abx162232
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Rabbit anti-Separase (pS801) Antibody

DL92370A-100ul 100 ul
EUR 299
Description: ESP1; KIAA0165; Separin; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; Separase

Rabbit anti-Separase (pS801) Antibody

DL92370A-50ul 50 ul
EUR 209.3
Description: ESP1; KIAA0165; Separin; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; Separase

Rabbit anti-Separase (pS801) Antibody

YLD7066-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to Separase (pS801)

Rabbit anti-Separase (pS801) Antibody

YLD7066-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to Separase (pS801)

Separin Phospho-Ser801 (ESPL1 pS801) Antibody

20-abx326180
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Separin Phospho-Ser801 (ESPL1 pS801) Antibody

abx326180-100g 100 µg
EUR 250

Separin Phospho-Ser801 (ESPL1 pS801) Antibody

abx326180-50g 50 µg
EUR 187.5

PAK1/2/3 Antibody (pS144/pS141/pS139)

RQ4789 100ul
EUR 356.15
Description: PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.

PAK4/5/6 Antibody (pS474/pS560/pS602)

RQ4826 100ul
EUR 356.15
Description: PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.

PS-2231-1000-GR AB Labels

622425 Roll of 100 Label(s)
EUR 204.75
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-2231-1000-RD AB Labels

622426 Roll of 100 Label(s)
EUR 204.75
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-2231-1000-WT-2 AB Labels

622427 Roll of 400 Label(s)
EUR 225.24
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PAK1/PAK2/PAK3 (pS144+pS141+pS139) Antibody

abx242983-96tests 96 tests
EUR 287.5

PAK4/PAK5/PAK6 (pS474/pS560/pS602) Antibody

abx243045-96tests 96 tests
EUR 287.5

PS372424

HY-111149 5mg
EUR 404.4

PS372424

T12567-10mg 10mg Ask for price
Description: PS372424

PS372424

T12567-1g 1g Ask for price
Description: PS372424

PS372424

T12567-1mg 1mg Ask for price
Description: PS372424

PS372424

T12567-50mg 50mg Ask for price
Description: PS372424

PS372424

T12567-5mg 5mg Ask for price
Description: PS372424

PS121912

T24675-10mg 10mg Ask for price
Description: PS121912

PS121912

T24675-1g 1g Ask for price
Description: PS121912

PS121912

T24675-1mg 1mg Ask for price
Description: PS121912

PS121912

T24675-50mg 50mg Ask for price
Description: PS121912

PS121912

T24675-5mg 5mg Ask for price
Description: PS121912

PS372424 HCl

561491 5.0mg
EUR 350

Smad2 (pS465 / 467) / Smad3 (pS423 / 425) Antibody

20-abx125449
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Smad2 (pS465 / 467) / Smad3 (pS423 / 425) Antibody

abx125449-100l 100 µl
EUR 200

Smad2 (pS465 / 467) / Smad3 (pS423 / 425) Antibody

abx125449-1ml 1 ml
EUR 475

Smad2 (pS465 / 467) / Smad3 (pS423 / 425) Antibody

abx125449-200l 200 µl
EUR 325

PS-2231-1000-WT AF Systems Consumables

032206 Roll of 100 Label(s)
EUR 212.89
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-2231-1000-YL AF Systems Consumables

032216 Roll of 100 Label(s)
EUR 238.31
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

3PS-1000-2-WT AB Labels

622009 Roll of 250 Piece(s)
EUR 402.21
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-1000-2-YL AB Labels

622010 Roll of 250 Piece(s)
EUR 402.21
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

PS-094-150-WT AB Labels

032612 Roll of 2500 Piece(s)
EUR 958.21
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-125-150-WT AB Labels

032613 Roll of 2500 Piece(s)
EUR 1001.74
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT AB Labels

032614 Roll of 2500 Piece(s)
EUR 1268.58
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-250-150-WT AB Labels

032615 Roll of 2500 Piece(s)
EUR 1535.85
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT AB Labels

032616 Roll of 1000 Piece(s)
EUR 874.9
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-500-150-WT AB Labels

032617 Roll of 500 Piece(s)
EUR 520.78
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

3PS-1500-2-WT AB Labels

142082 Roll of 250 Piece(s)
EUR 594.6
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-1500-2-YL AB Labels

142083 Roll of 250 Piece(s)
EUR 594.6
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-BK AB Labels

142084 Roll of 250 Piece(s)
EUR 594.6
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

PS-094-150-WT-2 AB Labels

622400 Roll of 5000 Label(s)
EUR 1054.02
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-094-150-WT-4 AB Labels

622401 Roll of 10000 Label(s)
EUR 1054.02
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-125-150-YL-2 AB Labels

622420 Roll of 10000 Label(s)
EUR 1101.91
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons pour marquage de fils PermaSleeve

PS-500-150-W-S-2 AB Labels

622444 Roll of 1000 Label(s)
EUR 330.44
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-094-150-WT-S AB Labels

032136 Roll of 500 Piece(s)
EUR 221.16
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-125-150-WT-S AB Labels

032137 Roll of 500 Piece(s)
EUR 231.2
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT-S AB Labels

032138 Roll of 500 Piece(s)
EUR 292.74
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-250-150-WT-S AB Labels

032139 Roll of 500 Piece(s)
EUR 354.44
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT-S AB Labels

032140 Roll of 250 Piece(s)
EUR 252.92
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-500-150-WT-S AB Labels

032141 Roll of 250 Piece(s)
EUR 300.39
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-125-150-WT-2 AB Labels

104675 Roll of 5000 Piece(s)
EUR 1101.91
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT-2 AB Labels

104676 Roll of 5000 Piece(s)
EUR 1395.45
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-250-150-WT-2 AB Labels

104678 Roll of 5000 Piece(s)
EUR 1689.43
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT-2 AB Labels

104679 Roll of 2000 Piece(s)
EUR 962.38
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-500-150-WT-2 AB Labels

104680 Roll of 1000 Piece(s)
EUR 572.85
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons pour marquage de fils PermaSleeve

PS-125-150-WT-3 AB Labels

104681 Roll of 7500 Piece(s)
EUR 1101.91
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT-3 AB Labels

104682 Roll of 7500 Piece(s)
EUR 1395.45
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-250-150-WT-3 AB Labels

104683 Roll of 7500 Piece(s)
EUR 1689.43
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT-3 AB Labels

104684 Roll of 3000 Piece(s)
EUR 962.38
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-YL-2 AB Labels

104728 Roll of 5000 Piece(s)
EUR 1395.45
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons pour marquage de fils PermaSleeve

PS-250-150-YL-2 AB Labels

104737 Roll of 5000 Piece(s)
EUR 389.87
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons pour marquage de fils PermaSleeve

3PS-1000-2-BR-S AB Labels

108397 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-GY-S AB Labels

108403 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-PK-S AB Labels

108409 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-VT-S AB Labels

108415 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-RD-S AB Labels

142067 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-OR-S AB Labels

142068 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-BL-S AB Labels

142069 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-GR-S AB Labels

142070 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-WT-S AB Labels

142085 Roll of 100 Piece(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-1500-2-YL-S AB Labels

142086 Roll of 100 Piece(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-BK-S AB Labels

142087 Roll of 100 Piece(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-RD-S AB Labels

142088 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-OR-S AB Labels

142089 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-BL-S AB Labels

142090 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-GR-S AB Labels

142091 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-GY-S AB Labels

142092 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-BR-S AB Labels

142093 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-PK-S AB Labels

142094 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1500-2-VT-S AB Labels

142095 Roll of 100 Label(s)
EUR 273.53
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

MDM2 (pS186 / pS188) Antibody

abx332845-100ul 100 ul
EUR 560.4

PS-094-150-WT-S-3 AB Labels

622402 Roll of 1500 Label(s)
EUR 243.27
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-094-150-WT-S-4 AB Labels

622403 Roll of 2000 Label(s)
EUR 243.27
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-250-150-WT-S-2 AB Labels

622428 Roll of 1000 Label(s)
EUR 389.87
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-250-150-WT-S-3 AB Labels

622429 Roll of 1500 Label(s)
EUR 389.87
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT-S-2 AB Labels

622433 Roll of 1000 Label(s)
EUR 278.22
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT-S-3 AB Labels

622434 Roll of 750 Label(s)
EUR 278.22
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-375-150-WT-S-4 AB Labels

622435 Roll of 1000 Label(s)
EUR 278.22
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-125-150-WT-S-2 AB Labels

104668 Roll of 1000 Piece(s)
EUR 254.33
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT-S-2 AB Labels

104671 Roll of 1000 Piece(s)
EUR 322.01
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-125-150-WT-S-3 AB Labels

104730 Roll of 1500 Piece(s)
EUR 254.33
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT-S-4 AB Labels

104758 Roll of 2000 Piece(s)
EUR 322.01
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

PS-187-150-WT-S-3 AB Labels

104768 Roll of 1500 Piece(s)
EUR 322.01
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

3PS-1000-2-WT-SC AB Labels

114242 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-1000-2-YL-SC AB Labels

114250 Roll of 100 Piece(s)
EUR 181.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

SMAD5 (pS463 + pS465) Antibody

abx243006-96tests 96 tests
EUR 287.5

SMAD5 (pS463/pS465) Antibody

abx243010-96tests 96 tests
EUR 287.5

PS-1031-500-RD AF Systems Consumables

622417 Roll of 250 Label(s)
EUR 367.9
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0231-094-WT AF Systems Consumables

032200 Roll of 500 Piece(s)
EUR 360.55
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0331-187-WT AF Systems Consumables

032202 Roll of 500 Piece(s)
EUR 421.61
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0531-250-WT AF Systems Consumables

032203 Roll of 500 Piece(s)
EUR 511.91
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0831-375-WT AF Systems Consumables

032204 Roll of 250 Piece(s)
EUR 376.78
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-1031-500-WT AF Systems Consumables

032205 Roll of 250 Piece(s)
EUR 436.78
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0231-125-YL AF Systems Consumables

032211 Roll of 500 Piece(s)
EUR 372.33
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0331-187-YL AF Systems Consumables

032212 Roll of 500 Piece(s)
EUR 421.61
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0531-250-YL AF Systems Consumables

032213 Roll of 500 Piece(s)
EUR 511.91
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-0831-375-YL AF Systems Consumables

032214 Roll of 250 Piece(s)
EUR 376.78
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PS-1031-500-YL AF Systems Consumables

032215 Roll of 250 Label(s)
EUR 375.26
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

PAK7 / PAK6 (pS602 / pS560) Antibody

abx333028-100ul 100 ul
EUR 560.4

PAK7 / PAK6 (pS602 / pS560) Antibody

abx333028-100g 100 µg Ask for price

PAK7 / PAK6 (pS602 / pS560) Antibody

abx333028-20g 20 µg
EUR 412.5

PAK7 / PAK6 (pS602 / pS560) Antibody

abx333028-50g 50 µg Ask for price

PS-1031-500-YL-2 AF Systems Consumables

622419 Roll of 1000 Label(s)
EUR 404.69
Description: Description Dutch: LS2000 PermaSleeve krimpkousen voor draadmarkering; Description French: LS2000 Manchons pour marquage de fils PermaSleeve

3PS-094-2-BK AB Labels

622343 Roll of 2500 Piece(s)
EUR 1044.36
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-125-2-GR AB Labels

622349 Roll of 2500 Piece(s)
EUR 1091.77
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-125-2-RD AB Labels

622351 Roll of 2500 Piece(s)
EUR 1091.77
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-250-2-BK AB Labels

622361 Roll of 2500 Piece(s)
EUR 1673.73
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-250-2-RD AB Labels

622365 Roll of 2500 Piece(s)
EUR 1673.73
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-375-2-RD AB Labels

622367 Roll of 1000 Piece(s)
EUR 953.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-500-2-RD AB Labels

622371 Roll of 500 Piece(s)
EUR 578.66
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-750-2-YL AB Labels

622374 Roll of 250 Piece(s)
EUR 350.32
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-375-2-OR AB Labels

130194 Roll of 1000 Piece(s)
EUR 925.69
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-094-2-YL AB Labels

032501 Roll of 2500 Piece(s)
EUR 1044.36
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-125-2-YL AB Labels

032502 Roll of 2500 Piece(s)
EUR 1091.77
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-187-2-YL AB Labels

032503 Roll of 2500 Piece(s)
EUR 1382.94
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-250-2-YL AB Labels

032504 Roll of 2500 Piece(s)
EUR 1673.73
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-375-2-YL AB Labels

032505 Roll of 1000 Piece(s)
EUR 953.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-500-2-YL AB Labels

032506 Roll of 500 Piece(s)
EUR 567.64
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons de repérage de fils PermaSleeve

3PS-125-2-WT AB Labels

032507 Roll of 2500 Piece(s)
EUR 1091.77
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-250-2-WT AB Labels

032508 Roll of 2500 Piece(s)
EUR 1673.73
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-500-2-WT AB Labels

032509 Roll of 500 Piece(s)
EUR 567.64
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-094-2-WT AB Labels

032510 Roll of 2500 Piece(s)
EUR 1044.36
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-187-2-WT AB Labels

032511 Roll of 2500 Piece(s)
EUR 1382.94
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

3PS-375-2-WT AB Labels

032512 Roll of 1000 Piece(s)
EUR 953.46
Description: Description Dutch: PermaSleeve krimpkousen; Description French: Manchons PermaSleeve pour marquage de fils

PS-1000-2-WT AB Labels

032606 Roll of 250 Piece(s)
EUR 402.21
Description: Description Dutch: PermaSleeve krimpkousen voor draadmarkering; Description French: Manchons PermaSleeve pour marquage de fils

Accelerate mitosis by the annulment of the spindle assembly checkpoint in overlapping temporal NEK2A enzymatic activity and separase and consequently cell death. We propose NEK2A and separase jointly inspect the integrity of the spindle assembly checkpoint and eliminate cells that are susceptible to chromosomal missegregation for accelerated development through early mitosis.

Karina

Related Posts

Structure and Function of the Separase-Securin Complex

Structure and Function of the Separase-Securin Complex

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Stability and pharmacokinetics of separase inhibitor-sepin-1 in sprague-dawley rats.

Identification of Bioactive Small Molecule Inhibitors of Separase.

Identification of Bioactive Small Molecule Inhibitors of Separase.

No Comment

Leave a Reply

Your email address will not be published.

April 2024
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  

Tags

Recent Posts

Categories